Dr. Lisa Reynolds @drlarey.bsky.social · 16/07/2025Our ongoing work is exploring the mechanisms through which different helminths can modify the bile acid pool in mouse models, and the consequences of helminth infection induced disruptions to the bile acid pool for the health of the host :) 030
Dr. Lisa Reynolds @drlarey.bsky.social · 16/07/2025We are excited to now add to these findings through exploring associations between different helminth infections and the fecal bile acid pool in school aged children. 120
Dr. Lisa Reynolds @drlarey.bsky.social · 16/07/2025Given that bile acids can regulate many aspects of gut physiology and immunity, we wanted to explore how helminth infection status might impact the fecal bile acid pool in people. Our previous work has indicated that helminth infection can disrupt the gut bile acid pool in mice! shorturl.at/JW4Myfrontiersin.orgFrontiers | Chronic small intestinal helminth infection perturbs bile acid homeostasis and disrupts bile acid signaling in the murine small intestineSoil-transmitted helminths are potent manipulators of the mammalian host immune system, and do so by dampening inflammation and inducing regulatory immune pa... 120
Dr. Lisa Reynolds @drlarey.bsky.social · 16/07/2025Gut-dwelling helminths are directly exposed to bile acids in the mammalian intestinal tract, and some some blood fluke infections can cause pathology in the mammalian liver, the site of bile acid synthesis. 120
Dr. Lisa Reynolds @drlarey.bsky.social · 16/07/2025(Spoiler, different infection statuses are associated with shifts to the bile acid pool and these differences appear to be sex-dependent!) 110
Dr. Lisa Reynolds @drlarey.bsky.social · 16/07/2025In our latest work we've explored associations between the fecal bile acid pool and helminth infection status in school aged children in Uganda. Have a read and see what we found!nature.comAssociations between helminth infection status and the composition and concentration of fecal bile acids in school-age children in UgandaScientific Reports - Associations between helminth infection status and the composition and concentration of fecal bile acids in school-age children in Uganda 1147
Reposted by Dr. Lisa ReynoldsNatasha Norton @natashajnorton.bsky.social · 15/07/2025Delighted to share my latest publication as a PhD candidate in @drlarey.bsky.social’s lab at @uvicscience.bsky.social! With our international collaborators we’re excited to share our findings on the associations between #helminths and fecal bile acids! 🪱 doi.org/10.1038/s415...doi.orgAssociations between helminth infection status and the composition and concentration of fecal bile acids in school-age children in Uganda - Scientific ReportsScientific Reports - Associations between helminth infection status and the composition and concentration of fecal bile acids in school-age children in Uganda 065
Reposted by Dr. Lisa ReynoldsDr. Raven the Science Maven @ravenscimaven.bsky.social · 10/07/2025NASA is more than rockets and moonwalks. NASA is behind much of our everyday technology. From space discovery, to Air Jordans, to CAT scans, NASA has played a role. We get it all on less than a penny of every federal dollar. Now their science may be gutted by 50%. #NASADidThat 25679812589
Reposted by Dr. Lisa ReynoldsDr. Dawn Bowdish @msmacrophage.bsky.social · 03/07/2025Hey @spaikin.bsky.social -I've been on your show, you should come to mine! I like to think that just as I feel smarter after watching @tvotoday.bsky.social or listening to #onpoli podcast, people leave my show knowing more than they did coming in. So geeky that @jm-mcgrath.bsky.social would approve.fringetoronto.comThe perils of being born in the Fall | Toronto Fringe Festival 071
Dr. Lisa Reynolds @drlarey.bsky.social · 25/04/2025Did you know that there are eosinophils in the thymus? Are you curious about what they might be doing there? If so please have a read of our latest review, where Dominique Gatti has summarized the status of the field and outstanding questions on this topic! :) academic.oup.com/jleukbio/art...academic.oup.comThymic eosinophils: What are you doing here?Eosinophils are present in thymus of humans and mice, and the heterogeneity of thymic eosinophil populations, their functional capacities, and the factors 091
Reposted by Dr. Lisa ReynoldsRodney DeKoter @rdekoter.bsky.social · 13/04/2025It’s a beautiful day for Immunology at #CSI2025 052
Reposted by Dr. Lisa ReynoldsHenry McSorley @henrymcsorley.bsky.social · 16/02/2025Our review on nematode immunomodulation is just out in Current Opinions in Microbiology! Here we discuss recent findings on immunomodulators with enzymatic or binding activities - binding to host cytokines or receptors, or other immune-relevant molecules. www.sciencedirect.com/science/arti...sciencedirect.comProtein families secreted by nematodes to modulate host immunityParasitic nematodes release a wide variety of immunomodulatory proteins, which allow them to escape the host’s immune-mediated killing or ejection mec… 0116
Dr. Lisa Reynolds @drlarey.bsky.social · 26/01/2025In the poster session tonight at #BIW2025, @natashajnorton.bsky.social will be sharing her work which is exploring how branched SCFAs might impact antibody responses in the gut and systemically. Please go visit Natasha if you want to learn more! 031
Dr. Lisa Reynolds @drlarey.bsky.social · 25/01/2025Are you at #BIW2025 and are you interested in worms? Please visit @biojen.bsky.social at her poster tonight and she’ll tell you all about worm-bile acid interactions in the gut! (If you’re not at BIW2025 don’t worry, stay tuned for more stories from Jenna soon, or reach out to us to chat anytime!) 044
Reposted by Dr. Lisa ReynoldsMichael Fischbach @mfgrp.bsky.social · 11/12/2024Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55 23693294
Reposted by Dr. Lisa ReynoldsDr. Rachael FitzPatrick @immunorach.bsky.social · 26/11/2024Come find me at poster #49 at #ASI2024 if you’re interested in gut #eosinophils and their response to an enteric #Salmonella infection 🐭 Or read about it here: doi.org/10.1128/iai.... & stay tuned, another poster from me coming later this week #oraltolerance 🍳🥜 071
Dr. Lisa Reynolds @drlarey.bsky.social · 24/11/2024Thank you for making this, could you add me please? 110
Reposted by Dr. Lisa ReynoldsLucille Rankin @lucillera.bsky.social · 20/11/2024go.bsky.app/7zMmwNY Hi all, so nice to cross over to the light. Here is a starter pack for all things Mucosal Immunology! Exciting to create a MI community here. Let me know if you would like to join 👍 636530
Dr. Lisa Reynolds @drlarey.bsky.social · 24/11/2024Thanks for doing this, please could you add me? 000
Dr. Lisa Reynolds @drlarey.bsky.social · 24/11/2024Thank you for doing this! Could you add me please? 010
Dr. Lisa Reynolds @drlarey.bsky.social · 24/11/2024Thank you for doing this! Could you add me please? 010