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Sam "The Mug Guy" Horrell

@drhorrell.bsky.social
986 followers 1.5K following 257 posts

Scientist 🧑‍🔬, structural biologist 🧬, X-ray Crystallographer 💎, Synchrotron Mug Enthusiast ☕, D&D 🎲 and MTG player 🧙, bird dad to Nori and Kili 🦜🦜 He/Him

PostsRepliesMedia
Sam "The Mug Guy" Horrell @drhorrell.bsky.social · 06/11/2025
I'm currently at LCLS in Stanford, anyone got a lead on where I might find a #SynchrotonMug to add to my collection? I know they exist. I've seen pictures!
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Sam "The Mug Guy" Horrell @drhorrell.bsky.social · 26/08/2025
Finally, a detector suitable for the new SynchroGnome beamlines. A giant leap forward in tiny science. #ROD10atECM #ECM
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Sam "The Mug Guy" Horrell @drhorrell.bsky.social · 25/08/2025
Made it to Poznan for the European Crystallography Meeting. Looking forward to presenting at the Science Slam on Thursday with the help of my cat Rosalind. #Crystallography #ECM35 #StructuralBiology #ScienceCommunication #SciComm #ScienceSlam
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Sam "The Mug Guy" Horrell @drhorrell.bsky.social · 20/08/2025
I don't want to alarm anyone, but I think my electron density might be haunted. 💎👻💀
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Sam "The Mug Guy" Horrell @drhorrell.bsky.social · 11/08/2025
Said goodbye to the @dectris.bsky.social Pilatus 6M the other day with one last #DetectorSelfie featuring beamline scientist Sofia. Collected some data to 0.87 A to give it a proper send off. Not sure how many images it has taken on I24 but it is very deserving of a rest.
2 people, a woman wearing glasses and a man with a beard, taking a picture in the reflective surface of a photon counting detector.
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Sam "The Mug Guy" Horrell @drhorrell.bsky.social · 19/06/2025
Protein structure or #Minecraft Creeper?
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Sam "The Mug Guy" Horrell @drhorrell.bsky.social · 13/06/2025
Taking bets on if this is crystalline or not. We'll find out next week on @diamondlightsource.bsky.social's VMXm next week with the help of @adamcrawshaw.bsky.social.
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Sam "The Mug Guy" Horrell @drhorrell.bsky.social · 05/06/2025
The electron microscope can't believe you just said that.
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Sam "The Mug Guy" Horrell @drhorrell.bsky.social · 29/05/2025
After 2 weeks of antibiotics twice a day Nori (left) now has a clean bill of health. Kili (right) is clearly pleased about this too.
A light yellow and grey cockateil and a dark grey peid cockateil put their heads together. One has their beak wide open. Both have very orange cheeks.
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Sam "The Mug Guy" Horrell @drhorrell.bsky.social · 22/05/2025
I was minding my own business watching a music video when suddenly I see @thewarningarmy.bsky.social have managed to crystallise themselves. So I thought I'd see if they diffract, and they do! #Crystallography #TheWarning #Crystal #Diffraction
A regular repeating pattern of Ale, Pau, and Danny from the  rock band The Warning. Effectively forming a 2D crystal of the band members. The reulsting diffraction pattern of the crystallised members of the warning. A Grey background with white spots in a regular repeating pattern.
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Sam "The Mug Guy" Horrell @drhorrell.bsky.social · 15/05/2025
If this #crystal space group isn't P3 or P6 I'll eat my #crystallography hat. It also reminds me of a tiny allen key.
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Reposted by Sam "The Mug Guy" Horrell
RCSB Protein Data Bank @rcsbpdb.bsky.social · 04/05/2025
Changes in PDB IDs are coming that will require use of PDBx/mmCIF file format... will you be ready? #MayThe4th Resources are available to help: www.wwpdb.org/docume...
Him: Structures in PDB format
Her: Do you mean mmCIF and not deprecated format, right?
Him: 
Her: RIGHT?
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Sam "The Mug Guy" Horrell @drhorrell.bsky.social · 04/05/2025
Happy #StarWars day from Nori and Kili. May the fourth be with you.
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Sam "The Mug Guy" Horrell @drhorrell.bsky.social · 02/05/2025
Pretty successful draft at the local game store. Won the event and got a chonky dragon. #MTG #MagicTheGathering
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Sam "The Mug Guy" Horrell @drhorrell.bsky.social · 01/05/2025
Blue copper crystals on a silicon chip.
A black silicon chip with regular etched square holes covered in blue/purple crystals.
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Sam "The Mug Guy" Horrell @drhorrell.bsky.social · 01/05/2025
New paper out today on a cyclic peptide which interacts with CD59, a protein that inhibits the complement mediated membrane attack complex. Some cool structural work went into this, modelling the cyclic peptide was an interesting challenge. onlinelibrary.wiley.com/doi/abs/10.1...
onlinelibrary.wiley.com
Macrocyclic Peptide Probes for Immunomodulatory Protein CD59: Potent Modulators of Bacterial Toxin Activity and Antibody‐Dependent Cytotoxicity
CD59 is an immunomodulatory cell surface receptor associated with human disease. Despite its importance in complement regulation and bacterial pathogenesis, CD59 remains a challenging therapeutic tar....
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Sam "The Mug Guy" Horrell @drhorrell.bsky.social · 18/04/2025
¡Olé! ¡Olé! ¡Olé! WARNING! Had a great time watching #TheWarning at Brixton last night.
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Sam "The Mug Guy" Horrell @drhorrell.bsky.social · 16/04/2025
Did someone say protein crystals? Someone probably said protein crystals.
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Sam "The Mug Guy" Horrell @drhorrell.bsky.social · 15/04/2025
What are the Rolling Stones doing in my electron density?
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Sam "The Mug Guy" Horrell @drhorrell.bsky.social · 15/04/2025
Do you think it's surprised to see me?
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Sam "The Mug Guy" Horrell @drhorrell.bsky.social · 15/04/2025
Classic Isoleucine behaviour
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Sam "The Mug Guy" Horrell @drhorrell.bsky.social · 15/04/2025
Post Bird?
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Reposted by Sam "The Mug Guy" Horrell
Martin Nutbeem @martinnutbeem.bsky.social · 15/04/2025
Post dog.
A large shaggy white dog sits next to a dog bed. He's giving his dogface.
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Sam "The Mug Guy" Horrell @drhorrell.bsky.social · 14/04/2025
A purrfectly normal envelope to have slid under my office door as a Crystallographer.
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Sam "The Mug Guy" Horrell @drhorrell.bsky.social · 13/04/2025
Hmm, looks orthorhombic primitive to me.
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Sam "The Mug Guy" Horrell @drhorrell.bsky.social · 03/04/2025
Had a lot of fun at the London final of #FameLab yesterday. Unfortunately as the runner up I won't be at the national final, but I did win the audience vote! Thanks for the kind words and advice from the judges @robinince.bsky.social, @funsizesuze.bsky.social, and @catherineloveday.bsky.social.
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The Spike Feeders @spikefeeders.com · 28/03/2025
IF YOU WANT TO WIN THE PRECONS WE PLAYED, REPOST THIS POST! We're giving them away inside a @gamegenic.com CARDS LAIR PRO 1000+ CONVERTIBLE! We'll pick a winner on Monday, March 31 at 12pm CT. Must follow us and @gamegenic.com to qualify.
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Sam "The Mug Guy" Horrell @drhorrell.bsky.social · 26/03/2025
From now on, if you're not wearing the appropriate PPE while using a Sharpie in the lab I'm going to have to have words with you. For safety.
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Sam "The Mug Guy" Horrell @drhorrell.bsky.social · 15/03/2025
I'll be presenting at the London #FameLab final in a few weeks! If there are any Londoners looking for an evening of accessible science talks you can get (free) tickets here. www.eventbrite.co.uk/e/london-fam...
eventbrite.co.uk
London FameLab Final
Experience the excitement of the London FameLab Final! Enjoy engaging science talks as contestants compete for a place in the UK Final.
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Reposted by Sam "The Mug Guy" Horrell
Charles Bayly-Jones @charlesbj.bsky.social · 09/03/2025
Sigh... the "protein folding problem" ≠ "structure predicition".
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Sam "The Mug Guy" Horrell @drhorrell.bsky.social · 08/03/2025
The magic of pressure washing.
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Sam "The Mug Guy" Horrell @drhorrell.bsky.social · 07/03/2025
Anyone ever grown circular protein crystals before? Taking bets on the space group.
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Sam "The Mug Guy" Horrell @drhorrell.bsky.social · 03/03/2025
Has anyone ever had their PEG 10,000 refuse to dissolve? I've got a user who can't make a 20% w/v solution because it just turns into paste. It should be soluble at 500g/L at 20 degrees C (50%) and I've checked their maths and it's correct.
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Sam "The Mug Guy" Horrell @drhorrell.bsky.social · 28/02/2025
Kili has no respect for the structural integrity of bridges. Just 2 rungs left before we can't legally call this a bridge anymore.
A small grey peid cockateil with red cheeks and a yellow crest strands on a bridge in which most of the rungs have been chewed and broken. They look pleased with their destructive work.
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Sam "The Mug Guy" Horrell @drhorrell.bsky.social · 28/02/2025
Roz has been helping me prepare for my #FameLab entry at.
A stuffed tabby cat with white paws sits on a laptop with a word document on the screen.
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Reposted by Sam "The Mug Guy" Horrell
Harry Low’s Lab @lowlab.bsky.social · 27/02/2025
❗️Exciting upcoming post-doc opportunity in the lab❗️🔔 If you have expertise in cryo-EM and bacterial secretion systems are your thing, then I’ll soon be advertising a long-term position funded by Wellcome Trust. Feel free to DM or email for early enquiries.. Thanks!
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Sam "The Mug Guy" Horrell @drhorrell.bsky.social · 27/02/2025
Thank you @xkcd.com for not making your DNA symmetrical! 10/10 for structural biology.
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Sam "The Mug Guy" Horrell @drhorrell.bsky.social · 27/02/2025
Good morning from Nori and Kili.
Kili, a dark grey spotted cockateil with outrage cheeks, hangs upside down so Nori, a yellow and light grey cockateil, can preen them.
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Sam "The Mug Guy" Horrell @drhorrell.bsky.social · 24/02/2025
Even more crystal growing success in the facility today! We've gone from tiny hexagonal disks to large hexagonal rods thanks to repeated seeding.
A shower of hexagonal protein crystals going from small to large with the biggest crystals in the middle. A cluster of hexagonal rod shaped clear protein crystals.
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Sam "The Mug Guy" Horrell @drhorrell.bsky.social · 24/02/2025
We have gone from clusters to single crystals for this project! Just needed a little bit of poison and considerably less precipitant. Now to make many many more of them.
A small clear singular protein crystal in a drop of liquid under a microscope. Three blurred crystals float in the background.
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Reposted by Sam "The Mug Guy" Horrell
Stephen Curry @scurry.bsky.social · 24/02/2025
Over 3250 signatures now and still rising. One more week to go.
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Sam "The Mug Guy" Horrell @drhorrell.bsky.social · 22/02/2025
Anyone got any ideas what animal this bone might be from?
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Sam "The Mug Guy" Horrell @drhorrell.bsky.social · 21/02/2025
Help! I'm trapped in a mirror vessel!
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Sam "The Mug Guy" Horrell @drhorrell.bsky.social · 19/02/2025
Getting closer and closer to nice big single crystals for this project. Think some of these might be ready for X-rays.
Microscopic hexagonal shaped protein crystals.
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Sam "The Mug Guy" Horrell @drhorrell.bsky.social · 19/02/2025
Couldn't agree more with the sentiments expressed in this letter.
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Sam "The Mug Guy" Horrell @drhorrell.bsky.social · 19/02/2025
#SynchrotronMugReviews: ALBA ALBA’s dark blue mug with white interior and synchrotron graphic is a simple but effective design. The handle is huge and very comfortable and the wide base gives great stability. Size: 8 Stability: 9 Handle: 9 Heat Retention: 7 Washability: 7 Design: 7 Total: 47/60
A dark blue and white mug with a white ALBA logo and a graphic of the ALBA synchrotron with text reading "Light to solve challenges of science" sits on a black slate coaster with an old school picture of atoms and electron density.
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Sam "The Mug Guy" Horrell @drhorrell.bsky.social · 17/02/2025
Just one bad day away from beginning my villain arc.
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Sam "The Mug Guy" Horrell @drhorrell.bsky.social · 17/02/2025
Wish me luck, I've thrown my hat into the ring for this year's #famelab competition. Best start planning my 3 minute talk on X-ray crystallography.
Text reading "University of Westminster" and "Welcome to Fame lab". Below this a blonde woman in a pink dress stands next to a bowl on a stool with colourful balls flying about the place. A blue sign behind her reads "fame lab talking science".
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