iiinova — where your digital self keeps evolving

Reposted by Drew Kiraly, MD, PhD

Dr. Lucky Tran @luckytran.com · 28/04/2025

Deaths from heart disease down 75%, that’s NIH. Deaths from stroke down 75%, that’s NIH. HIV/AIDS no longer a death sentence, that’s NIH. 99% of FDA approved drugs in the last decade, that’s NIH. Please show this video to anyone who doesn’t understand why the NIH is so important.

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Reposted by Drew Kiraly, MD, PhD

Jonathan Kipnis @jonykipnis.bsky.social · 15/04/2025

‼️BIG news ‼️ #ReThinkNeuroimmunology #RTN registration is open and live! The program is amazing! Hurry up to register while prices are low! See you in Boston in October! genelayinstitute.org/rtn/

genelayinstitute.org

ReThink - The Gene Lay Institute

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Reposted by Drew Kiraly, MD, PhD

Wake Forest Center for Addiction Research @wakeforestcfar.bsky.social · 14/04/2025

New publication from our CFAR members! PET imaging with [11C]MPC-6827 reveals disrupted microtubule integrity in a nonhuman primate model of alcohol use disorder. Check out the full study: doi.org/10.1016/j.dr...

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Reposted by Drew Kiraly, MD, PhD

NPP-Digital Psychiatry and Neuroscience (DPN) @dpn-journal.bsky.social · 02/04/2025

We are delighted to welcome Dr. Jibran Khokhar @drjkhokhar.bsky.social to our Editorial Board!! Dr. Khokhar's research focuses on the mechanisms underlying co-occurring mental illness & substance use disorders, and assessing how long-term adolescent cannabis use might contribute to disease risk.

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Drew Kiraly, MD, PhD @drewkiraly.bsky.social · 26/03/2025

Does anyone on here have experience with ELK Biotech products? I want to measure something by ELISA and theirs is significantly cheaper than the few others available, but want to make sure it is quality enough.

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Reposted by Drew Kiraly, MD, PhD

Katie Mack @astrokatie.com · 13/03/2025

The thing about scientific research is that it’s one of the few national investments that’s a clear public good even if you entirely discount the actual ostensible point of it.

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Reposted by Drew Kiraly, MD, PhD

Peter Sagal @petersagal.bsky.social · 11/03/2025

This letter appeared in the Bloomsburg PA Press Enterprise this morning. I am assured the writer is who he purports to be, an Air Force veteran.

benion
Grieving a wasted life
At a point in life when there are far too many days behind than ahead, one tends to
re-elected in contrast to standing up for the
reflect on a life lived. In my lifetime decades
greater good?
were devoted to protecting America. Sacri
A compromised Supreme Court recently
fices were made both by myself and my fam-
trotted out a shallow token standards of
Ily in military service. The tip of the spear:
conduct for themselves. Apparently it's
Countless weeks over the years were spent
not a bribe to accept favors after a deci-sion; only before. Corporations are people?
living at the end of a runway on alert with an Really? Whatever happened to Superman's armed B-52 as generations of aviators have motto of "truth, justice, and the American done before and since.
way?"
The purpose: if required, be airborne
Pay-to-play is the theme of the day. Un-
in minutes on a one-way trip bringing a
challenged and uncontested blatant conflicts
nuclear Armageddon to an adversary. Fly:
of interest abound. The rule of law is situ-
ing the unfriendly skies over North Viet-
ational if adhered to at all. America can no
nam provided a brief interlude, but overall,
longer be trusted. The unbridled pursuit of
this long line of silent sentinels stood firm
power and wealth driven by unquenchable
to protect America by deterring external
greed has left service above self and Con-
threats to our freedoms and way of life
stitutional norms in the dustbin of a quaint
across the decades. I was privileged to serve past. with men and women of integrity imbued
Recently the VA said exposure to Agent
with a sense of service.
Orange is the probable cause of the can-
I'm truly grateful that the B-52s we flew, which were built tough, were engineered
cers I live with. Actually I suspect it's more from yet unspecified sources, which cause
on scientific principles and fabricated by experienced, skilled workers rather than
military pilots to have significantly higher
founded on mere beli…

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Reposted by Drew Kiraly, MD, PhD

Wake Forest Center for Addiction Research @wakeforestcfar.bsky.social · 11/02/2025

Our next CFAR 2024 Research Round-Up post features work from the Kiraly Lab examining clinical and preclinical evidence for gut microbiome mechanisms in substance use disorders.

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Reposted by Drew Kiraly, MD, PhD

Wake Forest Center for Addiction Research @wakeforestcfar.bsky.social · 06/02/2025

Our next CFAR 2024 Research Round-Up post features work from the Egan Lab examining perceptions of disposal options for unused opioid analgesics among individuals prescribed opioids in North Carolina.

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Reposted by Drew Kiraly, MD, PhD

Wake Forest Center for Addiction Research @wakeforestcfar.bsky.social · 05/02/2025

Our next CFAR 2024 Research Round-Up post features work from the Rhodes Lab examining youth and young adult knowledge of and access to opioid harm reduction policies and interventions in North Carolina.

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Reposted by Drew Kiraly, MD, PhD

Wake Forest Center for Addiction Research @wakeforestcfar.bsky.social · 03/02/2025

Our next CFAR 2024 Research Round-Up post features work from the Hurley Lab on the NIH Pain Common Data Elements, highlighting progress, challenges, and future directions for improving pain assessment and data integration.

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Reposted by Drew Kiraly, MD, PhD

Wake Forest Center for Addiction Research @wakeforestcfar.bsky.social · 02/02/2025

Our next CFAR 2024 Research Round-Up post features work from the Nader Lab on behavioral and extracellular vesicle biomarkers linked to nicotine’s enhancement of cocaine reinforcement in male and female monkeys, highlighting sex-specific mechanisms in polysubstance use.

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Reposted by Drew Kiraly, MD, PhD

Wake Forest Center for Addiction Research @wakeforestcfar.bsky.social · 30/01/2025

Our first CFAR 2024 Research Round-Up post features work from the Nader Lab showing that the D3 receptor partial agonist (±)VK4-40 reduces the reinforcing strength of d-amphetamine but not cocaine in rhesus monkeys, offering insight into potential treatments for stimulant addiction.

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Drew Kiraly, MD, PhD @drewkiraly.bsky.social · 31/01/2025

A great thread highlighting recent work from our Center for Addiction Research. Would encourage anyone interested to follow along.

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Reposted by Drew Kiraly, MD, PhD

Tristan Shuman @tristanshuman.bsky.social · 28/01/2025

New paper out in Cell Reports! Led by @susieyufeng.bsky.social, we found that chronic epilepsy in mice drives distinct synchronization deficits in hippocampus and MEC, with early changes in HPC and late-onset changes in MEC that align with progressive memory impairment. www.cell.com/cell-reports...

Screenshot of article entitled "Distinct changes to hippocampal and medial entorhinal circuits emerge across the progression of cognitive deficits in epilepsy" by Yu Feng, Keziah S. Diego, Zhe Dong, ..., Nadia N. Khan, Denise J. Cai, and Tristan Shuman.

In brief: Feng et al. demonstrate that memory deficits in temporal lobe epilepsy involve multiple discrete mechanisms with distinct time courses. In epileptic mice, early-onset memory deficits are associated with disrupted hippocampal synchronization, while more severe, lateonset impairments are associated with disrupted synchrony of medial entorhinal cortex circuits.

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Reposted by Drew Kiraly, MD, PhD

Anna Molofsky Lab @annamolofskylab.bsky.social · 17/01/2025

a short think piece on one of the most mysterious substances in the brain - and one of my favorite topics @thetransmitter.bsky.social

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Drew Kiraly, MD, PhD @drewkiraly.bsky.social · 03/01/2025

First ever post on here to show off an exciting manuscript from the lab that has been a long time coming. Interactions of the microbiome and response to opioids in adolescent and adult mice: www.biorxiv.org/content/10.1...

biorxiv.org

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