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Davidmcmahon

@drdavidmcmahon.bsky.social
647 followers 223 following 29 posts

🇮🇪 Medical Oncologist Post CSCST research fellow in thoracic oncology @ Royal Marsden Hospital Arsenal fan (for my sins)

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Davidmcmahon @drdavidmcmahon.bsky.social · 07/10/2026
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Davidmcmahon @drdavidmcmahon.bsky.social · 07/10/2026
We had extensive input from the ctDNA implementation group and the UK circulating biomarkers network of excellence and the paper explores: On and off target findings, Germline findings, CHIP, Consent and communication, Need for patient-facing resources 3/4
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Davidmcmahon @drdavidmcmahon.bsky.social · 07/10/2026
It was my pleasure to write this important paper with my fantastic mentor Dr Terri McVeigh and colleagues, discussing the importance of discussing intended and additional findings of ctDNA NGS when performing liquid biopsy. 2/4
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Davidmcmahon @drdavidmcmahon.bsky.social · 07/10/2026
Genomic Analysis Using Liquid Biopsy: Considerations for Pretest Counseling in UK Practice | JCO Precision Oncology ascopubs.org/doi/10.1200/... 1/4
ascopubs.org
Genomic Analysis Using Liquid Biopsy: Considerations for Pretest Counseling in UK Practice | JCO Precision Oncology
Modern cancer diagnostics is heavily reliant on molecular data. Next-generation sequencing using liquid biopsy (LB) is primarily focused on identifying predictive and prognostic biomarkers to guide sy...
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BladeoftheSun @bladeofthes.bsky.social · 26/09/2026
Russia has been banned from International Football for 4.5 years. Israel who are committing Genocide hasn't been banned for 1 second. Ban Israel.
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Rich @richgooner1886.bsky.social · 25/09/2026
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David Ornstein @david-ornstein.bsky.social · 25/09/2026
🚨 EXCLUSIVE: Manchester City found guilty on virtually all charges relating to breaches of Premier League financial regulations. #MCFC expected to appeal against verdict issued by independent commission. Sanctions undecided, process ongoing @theathleticfc.bsky.social www.nytimes.com/athletic/704...
nytimes.com
Manchester City found guilty on almost all Premier League charges relating to financial breaches
City were charged by the Premier League in February 2023.
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Davidmcmahon @drdavidmcmahon.bsky.social · 24/09/2026
So Isreal are miming killing Palestinians on the pitch now? #stopthegame @ipsc.bsky.social
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Joe Louis Monte @jolomoco.bsky.social · 05/05/2026
I think it already is but, if Arsenal pull this off, it will be so embarrassing how criticised this Arsenal side & Arteta have been when in reality the achievement will be 1 of the top managerial/coaching feats for a while to transform this club in his 1st ever job to this ❤️⚪
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Davidmcmahon @drdavidmcmahon.bsky.social · 01/05/2026
€291,000 donated by @arseblog.com to good causes in 4 years. What an absolute hero that man (and team) is.
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YankeeGunner @arsenalvisionpodcast.com · 17/04/2026
A very special update, and a message of gratitude. ❤️
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arseblog @arseblog.com · 17/04/2026
Arsenal fans get a lot of stick online (some of it deserved tbf!) but the generosity of the ArsenalVision Podcast and Arseblog communities is always incredible. The consistency with which they show up and support such a good cause is more deserving of mention than some of the nonsense, but hey! ❤️
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Philippe Auclair @philippeauclair.bsky.social · 17/04/2026
A beautiful, deeply moving tribute by @arseblog.com to Alex Manninger, who died yesterday at the age of 48. arseblog.com/2026/04/on-a...
arseblog.com
On Alex Manninger
Morning. Hope you’re all well this Friday. I don’t really know where to begin, to be honest. I’ve done as much introspection as I can about the Sporting game. We won. We’re through. That is the most i...
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Davidmcmahon @drdavidmcmahon.bsky.social · 01/04/2026
@dralexiusjohn.bsky.social 🤣
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Davidmcmahon @drdavidmcmahon.bsky.social · 25/03/2026
@dralexiusjohn.bsky.social
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Davidmcmahon @drdavidmcmahon.bsky.social · 15/03/2026
@dralexiusjohn.bsky.social
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Musa Okwonga @okwonga.bsky.social · 13/03/2026
From a friend in Beirut this morning, who in the last few days has seen several Israel missile strikes within walking distance of their home.
it just feels so horrible
we feel powerless
we've tried fighting, 
we've tried surrendering
we've tried ignoring
we've tried building
israel doesn't let you exist
that's it, our choice is fast death 
or faster death
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arseblog @arseblog.com · 28/02/2026
I see the winner of the FIFA Peace Prize is at it again, doing more peace and stopping more wars. Oh. Get Infantino out of FIFA. Football deserves better than this ghoulish, obsequious, evil little toad of a man. He represents everything that's wrong about the game and the world.
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Davidmcmahon @drdavidmcmahon.bsky.social · 02/02/2026
#arsecastextra after Saturday there is an important question to be asked - who has reached a higher decibel level: the Highbury screamer or Gabriel Magalhaes?
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Davidmcmahon @drdavidmcmahon.bsky.social · 30/01/2026
pubmed.ncbi.nlm.nih.gov/41609978/ Delighted to explore the complex landscape of EGFRm NSCLC in 2026 with @drsanjaypopat.bsky.social and @dralexiusjohn.bsky.social Mechanisms of resistance FLAURA vs MARIPOSA vs FLAURA 2 Decision making after these regimens Genomic informed and agnostic approaches
pubmed.ncbi.nlm.nih.gov
Current and Emerging Treatment Landscape of Common EGFR-Mutated Advanced Non-small Cell Lung Cancer - PubMed
Osimertinib, a third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, has been standard of care as monotherapy for EGFR-mutated advanced non-small cell lung cancer since reporting of the FLAURA phase III clinical trial, which demonstrated superiority over first-generatio …
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Davidmcmahon @drdavidmcmahon.bsky.social · 24/01/2026
We explore: - Response to zongertinib - Acquired ERBB2 over expression and amplification - Subsequent near complete response to T-DXd - Potential rationale for T-DXd/TKI combination strategies in the future
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Davidmcmahon @drdavidmcmahon.bsky.social · 24/01/2026
Pleased to publish a case report exploring a number of interesting elements of ERBB2 (HER2) mutated NSCLC on @jtoonline.bsky.social with @drsanjaypopat.bsky.social and @dralexiusjohn.bsky.social www.jtocrr.org/article/S266...
jtocrr.org
Acquired ERBB2 amplification and overexpression as on-target resistance mechanisms to zongertinib with subsequent response to trastuzumab deruxtecan; a case report
A number of drugs are in development for the treatment of ERBB2(HER2)-mutated Non-Small Cell Lung Cancer (NSCLC) including antibody-drug conjugates (ADCs) such as trastuzumab deruxtecan (T-DXd) and ty...
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Davidmcmahon @drdavidmcmahon.bsky.social · 24/01/2026
We explore: -Response to zongertinib -Acquired ERBB2 over expression and amplification -Subsequent near complete response to T-DXd -Potential rationale for T-DXd/TKI combination strategies in the future
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Davidmcmahon @drdavidmcmahon.bsky.social · 15/12/2025
#arsecastextra last season we were comfortable soaking up pressure with an incredible defence in the last 10-15mins with a 1 goal lead. this season it feels like we are sucking the ball into the net. Do we need to change tack to a ball-dominant method of closing out games?
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Davidmcmahon @drdavidmcmahon.bsky.social · 04/09/2025
with that in mind, how uniform is the approach at top clubs regarding injury prevention? i imagine the management of the damage and road to recovery is very similar across the spectrum.
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Davidmcmahon @drdavidmcmahon.bsky.social · 04/09/2025
Given how subspecialised medicine is now, I seriously doubt the management of injuries is much different at Arsenal compared to any other top flight club. e.g I'm certain the players who had hamstring surgery last year all went to an orthopedic surgeon with a special interest in hamstrings. 1/2
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Phil Costa @philcosta.bsky.social · 08/04/2025
Right. I need match highlights in about 78 different languages ASAP because I'm not falling asleep anytime soon.
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Davidmcmahon @drdavidmcmahon.bsky.social · 06/04/2025
ascopubs.org/doi/10.1200/... very impressive efficacy and safety (manageable TRK-specific AEs) data for taletrectinib in ROS1+ NSCLC. ORR 88 and 56% (1L/2+L). 61% in the G2032R common resistance mutation. 76% intracranial response. mPFS 44.6m in the untreated population 👏
ascopubs.org
Taletrectinib in <i>ROS1</i>+ Non–Small Cell Lung Cancer: TRUST
PURPOSETaletrectinib is an oral, potent, CNS-active, selective, next-generation ROS1 tyrosine kinase inhibitor (TKI). We report integrated efficacy and safety from registrational taletrectinib studies...
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arseblog @arseblog.com · 03/04/2025
Arseblog will donate 100% of our Patreon revenue in April to four good causes: 🔴 The Arsenal Foundation 🔴 Oscar's Kids Ireland 🔴 UNICEF 🔴 Islington Foodbank Get loads of extra content, and help people who really need it for just $6 per month (+ VAT where applicable) 🙏 www.patreon.com/c/arseblog
Arseblog will donate 100% of our Patreon revenue in April to four good causes:

🔴 The Arsenal Foundation
🔴 Oscar's Kids Ireland
🔴 UNICEF
🔴 Islington Foodbank
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Davidmcmahon @drdavidmcmahon.bsky.social · 05/03/2025
Excellent conference at #BTOG25 My pleasure to present our data on SCLC, Mesothelioma and resectable NSCLC from The Royal Marsden
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Davidmcmahon @drdavidmcmahon.bsky.social · 04/03/2025
nice data!
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ALK Positive Lung Cancer UK @alkpositiveuk.bsky.social · 04/03/2025
Great first day at #BTOG25! An excellent advocates’ session in the afternoon, we presented our poster on real-world ALK+ #lungcancer treatment side effects & had valuable conversations with friends & colleagues. Looking forward to lots more today! @btog.bsky.social #LCSM
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Sanjay Popat @drsanjaypopat.bsky.social · 02/03/2025
Traveling to #BTOG25 today? Great thread from @tnewsomdavis.bsky.social on what you’ll experience. Get ready!
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@AAllenSport @aallensport.arseblog.com · 27/02/2025
Officially overtaken Arsene Wenger as the club's longest-serving manager.
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Davidmcmahon @drdavidmcmahon.bsky.social · 06/02/2025
- Neoadjuvant and adjuvant landscape - Pregnancy and family planning - Long term follow up, and the differences between the adjuvant and metastatic settings (can we de-intensify?) - Management of brain metastases - Evolving landscape of cellular therapeutics and individualised neoantigen therapies
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Davidmcmahon @drdavidmcmahon.bsky.social · 06/02/2025
Delighted to share this review “Navigating the landscape of immune checkpoint inhibitors and novel immunotherapies in melanoma: long-term outcomes, progress, and challenges” from the renal and skin units of the royal Marsden. www.tandfonline.com/doi/full/10....
tandfonline.com
Navigating the landscape of immune checkpoint inhibitors and novel immunotherapies in melanoma: long-term outcomes, progress, and challenges
Melanoma has become the poster child for transformative outcomes in advanced malignancy from the use of immunotherapy over the last 10–15 years with median survival improving from ~ 1 to > 5 years....
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Phil Costa @philcosta.bsky.social · 02/02/2025
Myles Lewis-Skelly, gargantuan performance. 🫡
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Arseblog News @arseblog.news · 02/02/2025
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Report: Arsenal 5-1 Manchester City (inc. goals)
Arsenal: Raya, Timber, Saliba, Gabriel, Lewis-Skelly, Partey, Rice, Odegaard, Trossard, Martinelli, Havertz Subs: Neto, Kiwior, Calafiori, Zinchenko, Tierney, Jorginho, Merino, Sterling, Nwaneri Arsenal ensured the gap between them and Liverpool remained…
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arseblog @arseblog.com · 26/01/2025
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Wolves 0-1 Arsenal: Gunners dig deep after another disgraceful refereeing decision
Match report – Player ratings – Arteta reaction – Video Ten man Arsenal came away from Wolves with all three points yesterday, despite the best efforts of referee Michael Oliver who once again issued an absurd red card to one of our players. A few years…
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James Benge @jamesbenge.bsky.social · 25/01/2025
What I'm calling Arsenal's Big Three -- Saka, Odegaard, Saliba -- have all been in the Premier League starting XI in 10 of 22 matches this season. Include Rice and it's just eight. There has been one starting XI since August to contain White, Rice, Saka, Saliba and Odegaard (Chelsea, away).
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Scott Willis @scott.cannonstats.com · 24/01/2025
Premier League cumulative spending on net spend for transfers and wages 2019/20 to 2023/24
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arseblog @arseblog.com · 22/01/2025
p1r.es
Dinamo Zagreb preview + Arteta on forward spending
Morning all. We’re in Champions League action this evening, taking on Dinamo Zagreb at home, and having been pushed down the table a bit by some of last night’s results (Barcelona’s win against Benfica was wild!). It goes without saying it’s a game we…
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Davidmcmahon @drdavidmcmahon.bsky.social · 22/01/2025
Fair play
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arseblog @arseblog.com · 22/01/2025
Here's today's blog with a preview of tonight's game, and an explanation as to why Arseblog and Arseblog News will no longer post content to Twitter. 👇
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Philippe Auclair @philippeauclair.bsky.social · 21/01/2025
How does John Textor get away with it? After Nuamah, 'bought' by Molenbeek and sent straight to Lyon, here is Botafogo's record signing Thiago Almada also being sent out to the L1 club. For free. This is how multi-club ownership is allowed to skew fair competition. www.lequipe.fr/Football/Act...
lequipe.fr
Toulouse dépose une réclamation concernant la qualification de Thiago Almada, la dernière recrue de l'OL
Toulouse a déposé des réserves avant son match à Lyon (0-0), samedi, pour contester la qualification de Thiago Almada, arrivé de Botafogo. Il les confirmées ce lundi auprès de la LFP.
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Jeremy Corbyn @jeremycorbyn.bsky.social · 27/12/2024
Israel has destroyed the last remaining hospital in northern Gaza. We have witnessed the total decimation of Palestinian healthcare, met with silence from political leaders who refuse to acknowledge the horrors they have enabled. This is the dehumanising reality of genocide.
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@AAllenSport @aallensport.arseblog.com · 28/12/2024
I was fine with them fixing the hamstring, but amputating his left arm is too much. FFS.
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Tim Stillman ⭐️⭐️ @tim-stillman.bsky.social · 28/12/2024
The decision (and it is a clear and conscious policy) of Howard Webb to totally disregard violent conduct and player safety and to fuss endlessly about shit that nobody cares about continues to irritate me profoundly.
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