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Chris Hill

@dochill1982.bsky.social
479 followers 43 following 53 posts

Nephrologist. Liverpool FC, cricket and Test Match Special fan. Proud dad of Lucy and Rose

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Chris Hill @dochill1982.bsky.social · 03/10/2026
Shout for our trainee Dr Rachel McDougall for getting this case published - impact of CFTR modulators on CF-associated AA amyloid academic.oup.com/ckj/article/...
academic.oup.com
Treatment with CFTR modulators and subsequent remission of AA amyloidosis
ABSTRACT. Cystic fibrosis transmembrane conductance regulator (CFTR) modulators have been revolutionary for cystic fibrosis patients. Their potential influ
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Chris Hill @dochill1982.bsky.social · 27/09/2026
Nice study and the big ticket result for me is the effects on eGFR slope of Sibeprenlimab compared to others. Would be interesting to add in dual inhibitors like Atacicept for comparison!
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NEJM.org @nejm.org · 31/08/2026
Catheter-directed thrombolysis led to a lower risk of death, recurrent pulmonary embolism, or cardiorespiratory decompensation or collapse at 7 days than anticoagulation alone in intermediate-high–risk acute pulmonary embolism. Full PRAGUE-26 trial results: nej.md/4wyGCwb #ESCCongress
A table comparing primary outcomes of thrombolysis and standard care (death from any cause, recurrence of pulmonary embolism, or cardiorespiratory decompensation or collapse). A primary-outcome event occurred in 2
patients (0.7%) in the thrombolysis group and in 19 patients (6.8%) in the standard-care group. The relative risk was 0.10 (95% CI: 0.02–0.44).
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NEJM.org @nejm.org · 27/08/2026
A patient with type 1 diabetes received genetically modified allogeneic islets and no immunosuppression. Results obtained through 14 months support β-cell function and a lack of immune response against the allograft. Full study results: nej.md/4wW5wGB
A graph showing the circulating C-peptide concentrations before and after transplantation and corresponding glucose management indicator (GMI) values (with each GMI calculated on the basis of the average glucose level over a period of 14 days).
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Chris Hill @dochill1982.bsky.social · 13/08/2026
(Very) makeshift pinhole camera used to view the eclipse last night #dontgiveupthedayjob Remarkably it did actually work!
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Arkana Labs @arkanalabs.bsky.social · 12/08/2026
Here is today’s #eyeSCANdy! Acellular scanning EM showing "craters" at high power on the subepithelial aspect of the glomerular basement membranes from a biopsy with membranous glomerulonephritis. Photo courtesy of Dr. Stephen Bonsib. #renal #pathology #kidneypath
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NEJM.org @nejm.org · 09/08/2026
In adults without diabetes who had chronic kidney disease, the nonsteroidal mineralocorticoid receptor antagonist finerenone led to a slower decrease in the estimate glomerular filtration rate than placebo over 32 months. Full FIND-CKD trial results and Research Summary: nej.md/4wWOFV4
This image contains an excerpt from the Research Summary "Finerenone in Persons with Chronic Kidney Disease without Diabetes" published in the New England Journal of Medicine. It includes a diagram showing CKD without diabetes and participant statistics: 1,584 adults, average age 55, with 66% men and 34% women. Below are illustrations of finerenone and placebo pill bottles, each accompanied by participant numbers: N=793 for the former, and N=791 for the latter. A prompt to read the full Research Summary at NEJM.org sits at the bottom.
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Chris Hill @dochill1982.bsky.social · 10/06/2026
Another great trial from #CCR26 presented in Belfast - carbocisteine and hypertonic saline cause harm in ventilated patients
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Chris Hill @dochill1982.bsky.social · 10/06/2026
Clinically v relevant results presented at #CCR26 in Belfast. Oseltamivir *worsens* outcome in ICU patients with Influenza!
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Chris Hill @dochill1982.bsky.social · 05/06/2026
This is good but what we really want is an Obi v Ritux trial
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kireports.bsky.social @kireports.bsky.social · 22/05/2026
Clinical Equipoise and Unimproved Outcomes following Posttransplant Cutaneous Squamous Cell Carcinoma #VisualAbstract by Krithika Mohan www.kireports.org/article/S2468-024… @bottomleymatt
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Chris Hill @dochill1982.bsky.social · 16/05/2026
Excited for @kidneyboy.bsky.social to start his talk at Irish Nephrology Society!
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American Journal of Kidney Diseases @ajkd.bsky.social · 28/04/2026
The Roles of A Proliferation-Inducing Ligand (APRIL) and B-Cell Activating Factor (BAFF) in IgA Nephropathy bit.ly/4rzPtLO
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Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 21/04/2026
Another e-alert failure in Kidney International this time www.kidney-international.org/article/S008... With commentaries: - www.kidney-international.org/article/S008... - www.kidney-international.org/article/S008...
Visual abstract
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American Journal of Kidney Diseases @ajkd.bsky.social · 10/03/2026
The Roles of A Proliferation-Inducing Ligand (APRIL) and B-Cell Activating Factor (BAFF) in IgA Nephropathy bit.ly/4rs0u1r
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Chris Hill @dochill1982.bsky.social · 06/03/2026
@askrenal.bsky.social anyone in England/Scotland/Wales - do you have to dispense Kinpeygo and Sparsentan direct from hospital pharmacy or is it available via community pharmacy? In NI we have to dispense direct from hospital due to an issue about cost parity in primary care.
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Chris Hill @dochill1982.bsky.social · 03/03/2026
Looking forward to our March teaching session for neph trainees in NI! It’s all about the #NephMadness!
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JAMA @jama.com · 03/03/2026
IgA nephropathy is the most common cause of immune-mediated glomerular disease worldwide. 📄 This Review summarizes the pathophysiology, epidemiology, clinical presentation, diagnosis, treatment, and prognosis of primary IgA nephropathy in adults. ja.ma/47bIhht
Illustration of IgA Nephropathy pathophysiology from JAMA. Four-hit hypothesis shows: 1) Aberrant IgA1 production; 2) Gd-IgA1 entering circulation; 3) Immune complex formation; 4) Complex deposition in glomerulus. Published online January 26, 2026.
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Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 24/02/2026
This week we discuss the 2026 KDIGO anemia guidelines on #NephJC Read our deep dive into the data here www.nephjc.com/news/kdigo-a...
nephjc.com
2026 KDIGO Anemia Management Guidelines — NephJC
This week, we will discuss 2026 KDIGO anemia management in patients with kidney disease
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Edgar V. Lerma 🇵🇭 @edgarvlermamd.medsky.network · 21/02/2026
Real-World Hospitalization Outcomes with On-Line Hemodiafiltration Versus High-Flux Hemodialysis ca. 2025 from @asnpublications.bsky.social #Nephpearls #NephSky #VisualAbstract by @husamjz.bsky.social 👉 pubmed.ncbi.nlm.nih.gov/41433104/
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Chris Hill @dochill1982.bsky.social · 20/02/2026
#askrenal @nephjc.bsky.social have a young male with multisystem sarcoid. Eyes, liver, hilar LNs and interstitial nephritis. Granulomas so big you could pick them out without magnification on histo slide! Any experience of anti TNF as steroid sparing for renal involvement?
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aspneph.bsky.social @aspneph.bsky.social · 09/02/2026
A secondary analysis of the TESTING trial predicted individual patient response to corticosteroid treatment in IgA nephropathy #nephsky
buff.ly
A secondary analysis of the TESTING trial predicted individual patient response to corticosteroid treatment in IgA nephropathy
Corticosteroids are effective for treating IgA nephropathy but have important adverse effects. In this secondary analysis of the TESTING cohort, we generated a model to predicts, for an individual…
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American Journal of Kidney Diseases @ajkd.bsky.social · 05/02/2026
Exercise and Kidney Health: Core Curriculum 2026 bit.ly/3YK6uXv (OPEN ACCESS)
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kireports.bsky.social @kireports.bsky.social · 23/01/2026
Systematic Review of Efficacy and Safety of #Avacopan in #RealWorld Clinical Practice #VisualAbstract by @Cteodosiu www.kireports.org/article/S2468-024…
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Lupus UK @lupusuk.bsky.social · 22/01/2026
NICE have recommended that a new treatment, obinutuzumab, can be used in combination with mycophenolate mofetil (MMF) to treat some patients with lupus nephritis in the NHS in England and Wales.  👉 Learn more at lupusuk.org.uk/latest-news #Lupus #LupusNephritis #Obinutuzumab
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NEJM.org @nejm.org · 10/01/2026
PISCES trial: More than two thirds of patients receiving hemodialysis for end-stage kidney disease are affected by cardiovascular disease. Research findings on fish-oil supplementation in patients treated with hemodialysis are summarized in a new Quick Take video. nej.md/3YsyWx2 #MedSky
A visual representation of the PISCES trial, which assessed whether fish oil could prevent cardiovascular events in patients on hemodialysis.
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Chris Hill @dochill1982.bsky.social · 05/01/2026
View from the office this morning. Sunrise over #Belfast
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Chris Hill @dochill1982.bsky.social · 30/11/2025
@leannestratton.bsky.social one for you
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American Journal of Kidney Diseases @ajkd.bsky.social · 29/11/2025
Quantifying APOL1, Human Leukocyte Antigen, and Other Genetic Contributions to Unexplained Kidney Failure #OpenAccess bit.ly/4nfGoXe
Breakdown of solved cases by gene category. Breakdown of the solved uKF cases by gene and phenotypic category. All percentages represent a proportion of the total solved cases (n=38). ADTKD, autosomal dominant tubulointerstitial kidney disease; CAKUT, congenital anomalies of the kidneys and urinary tract.
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kireports.bsky.social @kireports.bsky.social · 14/11/2025
#Delphi Consensus on Surrogate Endpoints in #C3G and Primary #ICMPGN #VisualAbstract by Jade Teakell, MD www.kireports.org/article/S2468-024…
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Chris Hill @dochill1982.bsky.social · 08/11/2025
Wonder what it would be like in a head to head with obinutuzumab? Used it successfully for first time recently in young male with min change who didn’t respond to ritux
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Joel Topf @kidneyboy.bsky.social · 08/11/2025
Simultaneous publication in the NEJM #KidneyWk www.nejm.org/doi/full/10....
nejm.org
Sibeprenlimab in IgA Nephropathy — Interim Analysis of a Phase 3 Trial | NEJM
The cytokine A proliferation-inducing ligand (APRIL) is considered a key driver of the pathogenesis of IgA nephropathy. Sibeprenlimab, a humanized IgG2 monoclonal antibody, selectively binds to and...
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Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 08/11/2025
And another ns-MRA Balcinrenone added to Dapa in proteinuric CKD #KidneyWK @thelancet.com www.thelancet.com/journals/lan...
thelancet.com
Balcinrenone in combination with dapagliflozin compared with dapagliflozin alone in patients with chronic kidney disease and albuminuria: a randomised, active-controlled double-blind, phase 2b clinica...
In participants with chronic kidney disease at increased risk of disease progression, a fixed dose combination of balcinrenone and dapagliflozin was superior to dapagliflozin alone in reducing albumin...
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Chris Hill @dochill1982.bsky.social · 07/11/2025
After all the fancy new medications we’ve tried in HD to improve prognosis… We should just have given them cod liver oil! #KidneyWk #nephjc
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NEJM.org @nejm.org · 07/11/2025
In the PISCES trial involving participants receiving hemodialysis, fish oil (n−3 fatty acids) was compared with corn-oil placebo. The rate of serious cardiovascular events was lower with daily fish-oil supplementation. Full trial results: nej.md/49zWuqo @asnkidney.bsky.social | #KidneyWk
American Society of Nephrology Kidney Week 2025 
Original Article | Nov. 7, 2025 | NEJM.org 
Fish-Oil Supplementation and Cardiovascular Events in Patients Receiving Hemodialysis 

Fig. 1A. A Serious Cardiovascular Events 

The NEJM identity sits at the bottom.
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ASN Publications @asnpublications.bsky.social · 07/11/2025
Now live in #ASNJASN, simultaneously published with #KidneyWk: "Immunosuppression in Older Kidney Transplant Recipients: A Randomized Controlled Trial" Read more: kidney.pub/JASN0924
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kireports.bsky.social @kireports.bsky.social · 07/11/2025
#Infliximab for Grade III/IV #ICI #Nephritis Clinical and Translational Evidence #VisualAbstract by Edgar V. Lerma 🇵🇭 www.kireports.org/article/S2468-024…
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NEJM.org @nejm.org · 06/11/2025
ORIGIN phase 3 trial: In an interim analysis of a clinical trial, atacicept, a fusion protein that binds and inhibits two cytokines thought to be central to the pathophysiology of IgA nephropathy, significantly reduced proteinuria. nej.md/3JEq8QL @asnkidney.bsky.social | #KidneyWk
American Society of Nephrology Kidney Week 2025 
Original Article | Nov. 6, 2025 | NEJM.org 
A Phase 3 Trial of Atacicept in Patients  with IgA Nephropathy 

Figure 2A. Change from Baseline in 24-Hr Urinary Protein-to-Creatinine Ratio through Week 36. 

The NEJM identity sits at the bottom.
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josh farkas 💊 @pulmcrit.bsky.social · 29/10/2025
The BICAR-ICU-2 trial just dropped! RCT involving IV bicarb in metabolic acidosis among patients with mod-severe AKI Bicarb didn't affect mortality but it reduced the need for dialysis & risk of bacteremia VERY similar conclusions to BICAR-ICU-1 🧵 #1/ jamanetwork.com/journals/jam... #EMIMCC
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Nephrology Journal Club @nephjc.bsky.social · 21/10/2025
Last #NephJC short on individual data meta-analysis showing that although we love flozins for their extensive benefits we actually don’t completely understand how they work #Nephsky ✍️Meta by @willkidney.bsky.social & co 📝 Write up by @nephroseeker.medsky.social www.nephjc.com/news/2025/10...
nephjc.com
Empagliflozin, the kidney, and what we still don’t understand — NephJC
NephJC short on an empagliflozin meta-analysis
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Chris Hill @dochill1982.bsky.social · 11/10/2025
Curious to know what North American folks think about whether a drop in BP will be enough to get Baxdrostat licensed? In UK suspect NICE will want to see MACE data first to do cost-effectiveness analysis. #medsky #askrenal #nephjc
nejm.org
Efficacy and Safety of Baxdrostat in Uncontrolled and Resistant Hypertension | NEJM
Aldosterone dysregulation plays an important pathogenic role in hard-to-control hypertension. In several studies, baxdrostat, an aldosterone synthase inhibitor, reduced the seated systolic blood pr...
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Chris Hill @dochill1982.bsky.social · 11/10/2025
One for you @leannestratton.bsky.social
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UK Kidney Association @ukkidney.org · 10/10/2025
📆 Your first chance to register for #UKKW26 & preview the draft programme is coming on Monday 👀 Join us in spa town, Harrogate, this March for cutting-edge #KidneyCare symposia, lectures & workshops. 💡 Early bird registration = 10% savings! #KidneyProfessionals #KidneyHealth #KidneyEducation
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Chris Hill @dochill1982.bsky.social · 27/09/2025
Iptacopan for C3G is published. Currently going through NICE appraisal in UK
thelancet.com
Oral iptacopan therapy in patients with C3 glomerulopathy: a randomised, double-blind, parallel group, multicentre, placebo-controlled, phase 3 study
Iptacopan showed a statistically significant, clinically meaningful proteinuria reduction in addition to RAAS inhibitors and immunosuppression at 6 months. Iptacopan was well tolerated with an accepta...
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Nayan Arora @captainchloride.bsky.social · 17/09/2025
Interesting diuretic resistance study. Adunctive thiazides take the lead over loop intensification? Nice discussion on mechanisms of DR, both practical and hypothetical. #nephsky journals.lww.com/jasn/abstrac...
journals.lww.com
Loop Diuretic Dose Intensification versus Adjuvant Thiazide ... : Journal of the American Society of Nephrology
g diuretic resistance mechanism could optimize diuretic response. Methods: Patients hospitalized with heart failure and diuretic resistance (6-hour cumulative natriuresis <100 mmol after IV loop di...
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Chris Hill @dochill1982.bsky.social · 18/09/2025
www.nejm.org/doi/full/10.... Completely non-nephrology post but pretty cool that old fashioned aspirin cuts recurrence risk by half in certain bowel cancers
nejm.org
Low-Dose Aspirin for PI3K-Altered Localized Colorectal Cancer | NEJM
Aspirin reduces the incidence of colorectal adenoma and colorectal cancer among high-risk persons. Observational studies suggest that aspirin may also improve disease-free survival after diagnosis,...
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Chris Hill @dochill1982.bsky.social · 18/09/2025
Another new drug for IgA with the potential for major disease modifying effect!
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ISNkidneycare @theisn.org · 18/09/2025
➡️ Randomized, Double-Blind, Placebo-Controlled Phase 2a Study Assessing the Efficacy and Safety of Felzartamab for IgA Nephropathy www.kidney-internati...
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Joel Topf @kidneyboy.bsky.social · 18/09/2025
GLP1ra in ADPKD? pubmed.ncbi.nlm.nih.gov/40815122/
pubmed.ncbi.nlm.nih.gov
GLP-1RA Semaglutide Delays the Progression of ADPKD Through Regulation of Glycolysis, Mitochondria Function and Ketosis - PubMed
Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disease that is caused by mutations in PKD genes. Glucagon-like peptide-1 (GLP-1) receptor agonists (GLP-1RAs) are a class of medicati...
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Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 12/09/2025
Not just for albuminuria - flozination and co sequent glycosuria can result in interference for other biomarkers too Albuminuria data: pubmed.ncbi.nlm.nih.gov/36736537/
pubmed.ncbi.nlm.nih.gov
Interference of urinary albumin-to-creatinine ratio measurement by glycosuria: clinical implications when using SGLT-2 inhibitors - PubMed
Interference of urinary albumin-to-creatinine ratio measurement by glycosuria: clinical implications when using SGLT-2 inhibitors
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