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Reposted by Djamel Nehar-Belaid

Waggoner Lab @labwaggoner.bsky.social · 14/05/2026

@biorxivpreprint.bsky.social Lifestyle intervention is associated with attenuation of ER stress/inflammation and enhancement of naive immune cell identity in older adults with metabolic disease @ucarduygu.bsky.social doi.org/10.64898/202...

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Djamel Nehar-Belaid @dnehar.bsky.social · 01/08/2025

Thanks for referencing our work 🙏

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Djamel Nehar-Belaid @dnehar.bsky.social · 19/05/2025

Thank you for highlighting our study 🙏

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Djamel Nehar-Belaid @dnehar.bsky.social · 16/05/2025

10/10 Big thanks to all my co-authors, particularly Asunción Mejías (@StJude). I want to thank my mentors: Jacques Banchereau, Virginia Pascual ( @WCM), Duygu Ucar ( @thejacksonlab.bsky.social and Octavio Ramilo ( @stjuderesearch.bsky.social ) for their guidance and support.

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Djamel Nehar-Belaid @dnehar.bsky.social · 16/05/2025

9/10 The processed scRNA-seq dataset from our study is available in GEO: GSE206289. Fastq files are available in dbGAP: phs002655. Children/infants dataset (PMID:37776858): GSE239799. Adult dataset (PMID:33713619): GSE161918. Scripts from this study are here: github.com/dnehar/Infan...

github.com

GitHub - dnehar/Infants_Cov19: COVID-19 project

COVID-19 project. Contribute to dnehar/Infants_Cov19 development by creating an account on GitHub.

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Djamel Nehar-Belaid @dnehar.bsky.social · 16/05/2025

8/10 Our results suggest that infants with severe COVID-19 exhibit significantly more robust interferon responses than adults. This implies that unlike adults with severe COVID-19, defective IFN responses do not seem to be a common feature in infants.

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Djamel Nehar-Belaid @dnehar.bsky.social · 16/05/2025

7/10 In a combined analysis of infants and previously sequenced adults (generated by @tsanglab.bsky.social lab; PMID:33713619), infants display a similar ISG signature in monocytes but a markedly enhanced ISG signature in T and B cells, which is consistent with infant specific immune features.

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Djamel Nehar-Belaid @dnehar.bsky.social · 16/05/2025

6/10 In collaboration with Adolfo García-Sastre and Teresa Aydillo @mountSinai, we showed that of 13 convalescent serum available following acute COVID infection 12 demonstrated IgG directed at SARS-CoV-2 antigens. We were not able to detect anti-IFN autoantibodies in this group of patients.

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Djamel Nehar-Belaid @dnehar.bsky.social · 16/05/2025

5/10 We observed higher % of ISGhi CD4+, CD8+, and NK T cells in the acutely infected patients than in controls, and it appeared that higher number of infants in this hospitalized cohort demonstrated ISGhi clusters compared to infants with mild disease described in a prior cohort (PMID:37776858).

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Djamel Nehar-Belaid @dnehar.bsky.social · 16/05/2025

4/10 We described increased % of ISGhi CD16+ monocytes in infected infants, which differs from finding in adults, where CD16+ monocytes were contracted (PMID: 32810438). Also, infants with COVID-19 exhibited contraction of several DC subsets.

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Djamel Nehar-Belaid @dnehar.bsky.social · 16/05/2025

3/10 We observed higher % of interferon-stimulated genes (ISG)hi CD14+ monocytes in infected infants than controls. Notably, ISGhi IL1B+ CD14+ mo were increased in infected infants, which is consistent with our previous observations in children with lupus (PMID:32747814 and PMID: 39378884).

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Djamel Nehar-Belaid @dnehar.bsky.social · 16/05/2025

2/10 Conducting research of this kind in 2m-old infants is challenging, particularly due to the limited blood volume available (< 2 ml). While the immune response to SARS-CoV-2 infection in both adults and children is well characterized, cases of hospitalized infants with severe disease remain rare.

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Djamel Nehar-Belaid @dnehar.bsky.social · 16/05/2025

1/10 I am very excited to share our latest study, now out in @natcomms.nature.com. We applied a multidimensional approach to decipher the immune responses to SARS-CoV-2 infection in 2-month-old hospitalized infants. We analyzed: scRNA-of PBMCs, serum cytokines and antibody responses. rdcu.be/emkNa

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Djamel Nehar-Belaid @dnehar.bsky.social · 16/05/2025

Thank you for mentioning our work!

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Reposted by Djamel Nehar-Belaid

Emre Kocakavuk @ekocakavuk.bsky.social · 19/02/2025

📣 Open computational PhD & Postdoc positions! Excited about the open positions as part of our newly funded Emmy Noether Group are online now under kocakavuklab.vercel.app/joinus 📢 Please RT (what's the bsky equivalent here?) and distribute ! 👇A quick instruction on how to apply

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Reposted by Djamel Nehar-Belaid

Waggoner Lab @labwaggoner.bsky.social · 14/01/2025

Infants display reduced NK cell responses in RSV and increased inflammatory responses in SARS-CoV-2 infections doi.org/10.21203/rs....

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Reposted by Djamel Nehar-Belaid

John Tsang @tsanglab.bsky.social · 01/12/2024

Over the past year I gave some lectures on AI and Immunology including the keynote at NIAID and GSK Palio Meeting. I've been asked about sharing my slides, here they are: 1. slides: zenodo.org/records/1425... 2. NIAID meeting report: rdcu.be/d1VRw 3. Related: www.dropbox.com/scl/fi/y67z0...

zenodo.org

Towards AI Models of Human Immunity: Past, Present, Future

These are the slides I presented at the 2024 AI and Immunology - Exploring Opportunities and Challenges meeting.

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Reposted by Djamel Nehar-Belaid

Anna Obenauf @obenaufa.bsky.social · 27/11/2024

1/23 Big news for the #ObenaufLab! So excited to finally share our new study providing another puzzle piece, why immunotherapy fails in many tumors, now out in @Nature 🧵👇 www.nature.com/articles/s41...

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Djamel Nehar-Belaid @dnehar.bsky.social · 25/11/2024

Happy to have been part of such a nice study showing age related changes in mammary gland. Very important findings given that most breast cancers occur in older women. @jacksonlab.bsky.social #Aging #BreastCancer #ImmuneAging #Immunology #SingelCells

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Djamel Nehar-Belaid @dnehar.bsky.social · 22/11/2024

Wow ! What a fantastic news ! Good on MIT. Hope other institutions will fellow this landmark decision

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