Huntington's disease is primarily characterised by its neurodegenerative effects in the brain, which cause progressive decline in psychiatric, motor and cognitive function, but it also impacts…

Summary: Disease Models & Mechanisms has launched a Special Issue focused on paediatric genetic disease. Here, we discuss recent research that highlights common themes and challenges in this area of…

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The zebrafish is a powerful research tool for investigating vertebrate developmental biology and disease pathology through both large-scale and high-precis

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Neuromuscular diseases encompass disorders that impair muscle function, by either directly affecting voluntary muscle or indirectly affecting nerve and neu

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Summary: Fusion-driven pediatric soft tissue sarcomas are aggressive and lack targeted therapies. Transgenic fusion-driven animal tumor models are a platform to understand tumorigenic mechanisms and…

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Reasons to publish with DMM | Disease Models & Mechanisms | The Company of Biologists Reasons to publish in Disease Models & Mechanisms - discovery for human health Published by a not-for-profit…

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Reasons to publish with DMM | Disease Models & Mechanisms | The Company of Biologists Reasons to publish in Disease Models & Mechanisms - discovery for human health Published by a not-for-profit…

Summary: This Special Article provides a comprehensive overview of the methods, applications and considerations for the generation of cerebellar organoids.

The Company of Biologists is pleased to welcome Dan Shanahan as the new Chief Executive Officer, effective from 14 September 2026.

Summary: In Drosophila, the intestine releases the cytokine Upd3, which signals to the fat body and oenocytes to drive systemic hypoxia tolerance, a process kept in check by HIF-1α.

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A common epigenetic circuit may unite genetically diverse Acute Myeloid Leukemia. Targeting the SAGA complex dismantles leukemic identity.