Reposted by @denizugurlar.bsky.social

Happy to share our latest paper!
www.science.org/doi/10.1126/...
We visualized by cryo-EM how a disease-causing anti-HPA-1a antibody binds to integrin αIIbβ3 and locks it in an inactive state
Great colab with Coert Margadant’s lab & groups at Osaka Univ, Sanquin, CNB-CSIC, ISBG
Details below… 1/9