Blelloch and colleagues create genetically engineered universal human iPSCs, differentiate them into CCR7+ migratory dendritic cells, and dress them with tumor-derived MHC class I-antigen complexes to...

2026 Summer Intern - Translational Medicine Department Summary In Translational Medicine, our vision is to create the future of medicine by applying borderless, rigorous translational science to radic...

STAR Protocols is an open access, peer-reviewed journal from Cell Press. We offer structured, transparent, accessible, and repeatable step-by-step experimental and computational protocols from all are...

YouTube video by ASPI: Active Surveillance Patients International

YouTube video by The Flaming Lips - Topic

Total cell cycle duration is a key hallmark of cancer initiation, and determines whether defects in apoptosis, senescence, immune surveillance, angiogenesis, DNA repair, polarity and proliferation lea...

A large-scale analysis of DNA-bound transcription factors (TFs) shows how the presence of DNA markedly affects the landscape of TF interactions, and identifies composite motifs that are recognized by ...

Federal funding for biomedical research is under threat.

Gökbuget et al. use machine learning to quantify chromatin state changes that predict DNA replication timing changes during cell differentiation. By following up on top predictors through functional v...

Zhang et al. uncover different dynamics underlying the maintenance and regulation of H3K9me3-enriched heterochromatin domains in mouse embryonic stem cells and propose that loss of H3K9me3 occurs thro...

MDM2 has been pursued as an attractive therapeutic target for human cancers. Herein, we describe our discovery of MD-265 as a promising PROTAC MDM2 degrader and extensive in vitro and in vivo evaluati...