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Douglas Kell

@dbkell.bsky.social
1.8K followers 1.9K following 148 posts

Research Scientist who prefers facts to lies. Focus on Long COVID. Free book: osf.io/pnxcs.

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Douglas Kell @dbkell.bsky.social · 31/08/2026
I'm giving an online talk on our work w @resiapretorius.bsky.social on Fibrinaloid Microclot Complexes in #LongCOVID for @AcadOfNutriMed on September 1st at 7pm BST. Registration link at us02web.zoom.us/webinar/regi.... #TeamClots #pwME #pwLC
us02web.zoom.us
Welcome! You are invited to join a webinar: AONM Webinar With Professor Douglas B. Kell CBE . After registering, you will receive a confirmation email about joining the webinar.
'Fibrinaloid Microclot Complexes in Chronic Inflammatory Diseases such as Long COVID and M.E.' Long COVID, M.E. and other chronic inflammatory diseases continue to present significant challenges for ...
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 19/08/2026
From my wonderful Colleagues Team Clots... @resiapretorius.bsky.social @dbkell.bsky.social 😇🙏🏻 doi.org/10.1038/s414...
doi.org
Surface cues shape procoagulant properties of amyloidogenic microclots - Cell Death & Disease
Cell Death & Disease - Surface cues shape procoagulant properties of amyloidogenic microclots
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Douglas Kell @dbkell.bsky.social · 14/08/2026
New preprint with @resiapretorius.bsky.social Kell, D. B. and Pretorius, E. (2026) Atherosclerosis as a Localised Amyloid and Proteostasis Disorder. Preprints. 2026, 2026080868. doi.org/10.20944/pre... #TeamClots
doi.org
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Douglas Kell @dbkell.bsky.social · 08/08/2026
Took a while but it's finally out... Zhang, Y., Kell, D. B. and Borodina, I. (2026) Engineering and characterization of small-molecule transporters for cell factories. Trends Biotechnol. 44, 2248-2264. doi.org/10.1016/j.ti... @livuni-ismib.bsky.social
doi.org
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Douglas Kell @dbkell.bsky.social · 31/07/2026
New #OpenAccess summary of microclots in #LongCOVID with @resiapretorius.bsky.social: Grixti, J. M., Pretorius, E., Kell, D. B. (2026) Uncovering the hidden biology of fibrinaloid microclot complexes in complex, inflammatory diseases. QRB Discovery. 7, e9. doi.org/10.1017/qrd.... #TeamClots
doi.org
Uncovering the hidden biology of fibrinaloid microclot complexes in complex, inflammatory diseases | QRB Discovery | Cambridge Core
Uncovering the hidden biology of fibrinaloid microclot complexes in complex, inflammatory diseases - Volume 7
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Analyst @analyst.rsc.org · 09/07/2026
In the latest issue of ‪Analyst: Rapid antimicrobial susceptibility testing in bloodstream infections: current landscape and emerging technologies. #OpenAccess from Douglas B. Kell et al @dbkell.bsky.social @livuni-ismib.bsky.social Read now: pubs.rsc.org/an/article/d...
Visual abstract. Emerging rapid AST platforms for bloodstream infections aim to provide susceptibility results within hours, but sample preparation and organism–antibiotic coverage remain major challenges to routine clinical adoption.
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Douglas Kell @dbkell.bsky.social · 08/07/2026
New paper with @resiapretorius.bsky.social et al #TeamClots Roberts, I., Tan, X., Moore, J. B., Pretorius, E. and Kell, D. B. (2026) Bioinformatic assessment of the potential amyloidogenicity of the human and evolutionarily more ancient proteomes. Biochem J. 483, 1337-1355. doi.org/10.1042/BCJ2...
doi.org
Bioinformatic assessment of the potential amyloidogenicity of the human and evolutionarily more ancient proteomes
Abstract. AmyloGram is a computer program that uses n-gram encoding and a random forest classifier to produce a numerical score between 0 and 1 for the predicted amyloidogenicity of a given protein se...
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Douglas Kell @dbkell.bsky.social · 02/07/2026
New #OpenAccess review on yeast transporters published www.tandfonline.com/doi/full/10.... @livuni-ismib.bsky.social
tandfonline.com
Advances, challenges, and opportunities in engineering C5 and C6 sugar transporters in yeast for bio-based industrial biotechnology
Harnessing biomass for bio-based industrial biotechnology is vital for addressing global energy needs and mitigating climate change. In this context, microorganisms are the cornerstone of biorefine...
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Douglas Kell @dbkell.bsky.social · 17/06/2026
Our review of antimicrobial susceptibility testing is out pubs.rsc.org/en/content/a... @livuni-ismib.bsky.social
pubs.rsc.org
Rapid antimicrobial susceptibility testing in bloodstream infections: current landscape and emerging technologies
Rapid bloodstream infection diagnosis is essential to enable timely targeted therapy, to reduce the risk of progression to sepsis, to limit unnecessary antimicrobial exposure, and to support effective...
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Lorraine Reese @lorraine-reese.bsky.social · 11/06/2026
Celebrating 120 years of the Biochemical Journal, we're hosting a special free webinar on 17 June where @dbkell.bsky.social will be exploring how fibrinaloid microclots affect the microcirculation, and the effects on chronic inflammatory diseases. Register now 🧪 bit.ly/3S1m6pC
Graphic for Biochemistry Focus webinar series, showing connecting people and different viewing platforms such as phone, tablet and monitor. Includes graphic and logos for the Biochemical Society and Portland PressBiochemical Journal logo
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Douglas Kell @dbkell.bsky.social · 16/06/2026
Gearing up for @foundscitech.bsky.social chat between Lord Willetts and Sir Ian Chapman (UKRI boss).
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Douglas Kell @dbkell.bsky.social · 20/05/2026
If folk are interested, I am giving a @BiochemSoc talk on our work with @resiapretorius.bsky.social on Fibrinaloid Microclot Complexes in Long Covid and ME/CFS on June 17 at 2pm. Registration needed but free register.gotowebinar.com/register/226... #TeamClots #pwLC #pwME
register.gotowebinar.com
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Douglas Kell @dbkell.bsky.social · 14/05/2026
A SECOND review with @resiapretorius.bsky.social also published today Kell, D. B. and Pretorius, E. (2026) Assessing the Health and Functionality of the Microcirculation Using Thermal Imaging. J Biophotonics. 19, e70270. doi.org/10.1002/jbio... #TeamClots @livuni-ismib.bsky.social
doi.org
Assessing the Health and Functionality of the Microcirculation Using Thermal Imaging
We review the techniques of thermal imaging for assessing the functional consequences of lowered blood flow in the microcirculation that accompanies many chronic, inflammatory diseases. A comparison ...
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Douglas Kell @dbkell.bsky.social · 14/05/2026
New review with @resiapretorius.bsky.social Kell, D. B., Zhao, H. and Pretorius, E. (2026) Fibrinaloid Microclots-Induced Microcirculation Dysfunction: Mechanism and Laser-Based Haemodynamic Validation. Cardiovasc Sci. 3, 10005. doi.org/10.70322/cvs... #TeamClots @livuni-ismib.bsky.social
doi.org
Fibrinaloid Microclots-Induced Microcirculation Dysfunction: Mechanism and Laser-Based Haemodynamic Validation
The microcirculation typically refers to those capillaries less than 100 μm in diameter. We have shown that blood can clot into an anomalous amyloid form, manifesting as microclots of typically 2–200 ...
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Douglas Kell @dbkell.bsky.social · 13/05/2026
New review: Kell, D. B. and Roberts, I. (2026) How far can you go? Extrapolating values of catalytic activity from known protein landscapes in natural and directed evolution. Chem Soc Rev, in press. doi.org/10.1039/d5cs... @livuni-ismib.bsky.social
doi.org
How far can you go? Extrapolating values of catalytic activity from known protein landscapes in natural and directed evolution
The number of possible variants representing the landscape of a protein sequence of length N residues, made of the standard unmodified proteinogenic amino acids, is 20N; its exhaustive experimental an...
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Institute of Systems, Molecular and Integrative Biology @livuni-ismib.bsky.social · 13/05/2026
From dirt to discovery! In our latest blog, Dr Rachel Floyd and Dr Amy Wedley discuss how research-connected teaching can build the skills, confidence and scientific curiosity the next generation of bioscientists need. 🔗 bit.ly/43avzwV #TeamLivUni
A dark green social card that reads 'From dirt to discovery: training the next generation of bioscientists' in white text. Pictured is Dr Rachel Floyd taking a sample from a body of water on farmland.
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Elly Brosius, MS @ellybrosius.bsky.social · 08/03/2026
I love that the paper mentions PPAR agonists! Maybe we'll hear more at Roundtable with @dbkell.bsky.social & @resiapretorius.bsky.social (+ Dr. Vaughn + Dr. Schofield) + some very awesome panelists. Fri MAR 13 1 pm EDT US by @renegaderesearch.bsky.social us06web.zoom.us/webinar/regi...
us06web.zoom.us
Sign up for the free Research Roundtable on Hypercoagulability, Clotting and Microclotting, and Blood Issues in MECFS and Long Covid. Speakers: Resia Pretorius, Douglas Kell, Jordan Vaughn, Jill Schof...
A panel of clinicians and researchers will speak, followed by a Q&A and discussion. Your panel: Resia Pretorius, PhD - resiapretorius.net Distinguished Research Prof. of Physiological Sciences Ste...
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Renegade Research @renegaderesearch.bsky.social · 13/03/2026
What great presentations and illustrative slides. What a valuable discussion! Thank you to panelists @resiapretorius.bsky.social @dbkell.bsky.social Jordan Vaughn and Jill Schofield. We'll post recording link soon. We were about to wrap at 2 hr 50 min when webinar accidentally ended. Sorry.
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🤜❤️‍🔥🤛 Challenger 🧪 Sourcecontrol.bsky.social. 🦋 @sourcecontrol.bsky.social · 15/03/2026
March 13 at 1 pm ET (US) for a Research Roundtable with @resiapretorius.bsky.social of @livunipress.bsky.social @dbkell.bsky.social @jfvaughnmd09 discussing: Hypercoagulability, Clotting and Microclotting, and Blood Issues in ME/CFS and Long Covid 👇 youtu.be/FygtEROEqXE?...
youtu.be
Research & Clinician's roundtable on Hypercoagulability, and Blood Issues in MECFS and Long Covid
YouTube video by Renegade Research
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Renegade Research @renegaderesearch.bsky.social · 16/03/2026
What great presentations, illustrative slides, and a valuable discussion! Thanks to our panelists @resiapretorius.bsky.social @dbkell.bsky.social and Drs. Jordan Vaughn and Jill Schofield Thanks to our audience for your questions! The link to the YouTube recording is in the final post on this 🧵⬇️
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Douglas Kell @dbkell.bsky.social · 01/04/2026
mastodon.social/@We_Own_It/1...
mastodon.social
We Own It (@We_Own_It@mastodon.social)
BlackRock, one of the world’s largest asset managers, already owns 65 NHS GP surgeries. Now it wants to expand its UK empire by buying more NHS property, in a new venture with Greater Manchester Pen...
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Tania J. Spencer @taniaspencer.bsky.social · 04/02/2026
10/ This comprehensive study of treatment outcomes in 3,925 patients with #ME/CFS & #LongCOVID, examined over 150 supplements, #OTC medications, prescription medications - www.pnas.org/doi/10.1073/...
pnas.org
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
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Tania J. Spencer @taniaspencer.bsky.social · 04/02/2026
8/ "In the early era of HIV, we tried single-drug therapies, but nothing worked. Two drugs, that didn’t really work. Three drugs – boom": www.ucsf.edu/news/2026/01...
ucsf.edu
Solving Long COVID: How Decades of HIV Research Paved the Way
Discover how UCSF is leading the charge in Long COVID research, uncovering key findings that advance our understanding of the condition. UCSF researchers have adapted innovative tools and methodologie...
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Tania J. Spencer @taniaspencer.bsky.social · 04/02/2026
7/ Pay attention to this - ⚠️ "...there's going to be a number of Trials done on single drug therapy and they will fail I can predict it now..." #DrJacoLaubscher
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Tania J. Spencer @taniaspencer.bsky.social · 04/02/2026
4/ "How soon do most people notice benefits from proteolytic enzymes? The vast majority (3/4) reported benefits in under 2 weeks, and 42% noticed benefits within just 1 week": open.substack.com/pub/pharmd/p...
open.substack.com
TREAT ME Survey: Individual Treatment Results
Proteolytic Enzymes (Nattokinase, Lumbrokinase, Serrapeptase)
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Tania J. Spencer @taniaspencer.bsky.social · 04/02/2026
1/ I rarely repost any advice on apparent silver bullets for #LongCOVID, because I don't want to raise false hope. However, I make any exception for the #Microclot hypothesis. Anecdotally, it appeared to significantly help my son & I - @resiapretorius.bsky.social @dbkell.bsky.social
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Congresswoman Ayanna Pressley @pressley.house.gov · 27/01/2026
There's no ICE accountability without ending qualified immunity. They're murdering people. There won't be justice for the lives they've stolen, but there must be accountability. My bill with @markey.senate.gov would ensure families can sue the agents murdering their loved ones.
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NBC News @nbcnews.com · 27/01/2026
BREAKING: Two Republican senators, Thom Tillis and Lisa Murkowski, call for DHS Secretary Kristi Noem to resign.
nbcnews.com
Two Republican senators call for Kristi Noem to resign as DHS secretary
Sens. Lisa Murkowski and Thom Tillis are the first GOP members of Congress to call for Noem to step down as secretary of the Department of Homeland Security.
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Caroline Lucas @carolinelucas.bsky.social · 27/01/2026
Writing with @rupertread.bsky.social about just how devastating the Government- suppressed security report is, particularly its conclusions about our food insecurity. Ministers should be helping to build our resilience to these threats, not burying the report that contains them 👇
resilience.org
It's ecological breakdown that should put us on a war-footing: official
Admissions of extreme, eco-caused national security threats foreground importance of climate adaptation to bring much needed urgency and agency.
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Jenoco 🇨🇦 @jenoco.bsky.social · 27/01/2026
Ongoing genocide by terrorist russia. 🤬
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Truthout @truthout.org · 27/01/2026
Amid growing calls for the abolition of ICE, Rep. Delia Ramirez is calling for the entire DHS to be dismantled. Highlighting how much experience the officers who killed Renee Good and Alex Pretti had, Ramirez said, “DHS was built to violate our rights and has been empowered to act with impunity.”
truthout.org
House Democrat Says Abolishing ICE Isn’t Enough — DHS Must Go, Too
“The problem isn’t ‘training.’ DHS was built to violate our rights,” said Rep. Delia C. Ramirez.
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Tania J. Spencer @taniaspencer.bsky.social · 23/01/2026
20/ Next, I tried the same regimen on my then 23-year old son. And within weeks he noticed an improvement in multiple, unexplained severe pains in internal organs, & an amelioration of some of his #LongCOVID symptoms. More resources here, courtesy of @dbkell.bsky.social - dbkgroup.org/longcovid/
dbkgroup.org
Long COVID and the role of fibrin amyloid (fibrinaloid) microclots « Bioanalytical Sciences Group
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Tania J. Spencer @taniaspencer.bsky.social · 23/01/2026
13/ I can't tell you how many times I have spelled this word for health providers who feign mild interest but somehow never get around to looking it up. "But what exactly is #Nattokinase, and why does it work?": @resiapretorius.bsky.social @dbkell.bsky.social youtu.be/6q2WS4NuiBQ?...
youtu.be
Can Nattokinase Help Break Down 'Microclots'? | With Prof Resia Pretorius & Prof Doug Kell
YouTube video by Gez Medinger
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valebodi.bsky.social @valebodi.bsky.social · 14/01/2026
Massimo Nunes, Loren Kell, Anouk Slaghekke, Rob CI Wüst, Burtram C. Fielding, Douglas B. Kell & Etheresia Pretorius @resiapretorius.bsky.social @dbkell.bsky.social et al.
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We Own It @weownit.org.uk · 12/01/2026
🚨Thames Water is on the brink of collapse. 🙋We asked its customers what should happen next. 54% think the water regulator Ofwat should put it into special administration. And over two thirds (68%) believe that Thames Water should be run in the public sector. Read the full results here.
weownit.org.uk
New polling: majority of Thames Water customers want Ofwat to reject creditors’ proposal for the utility
New polling has revealed that 54% of Thames Water customers think Ofwat should reject a deal proposed by Thames Water's creditors, and put it into special administration.
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Tania J. Spencer @taniaspencer.bsky.social · 17/11/2025
1/ Those of us who developed unexplained bruising, among other vascular symptoms during the early years of #LongCOVID, are not at all surprised by this - @resiapretorius.bsky.social @dbkell.bsky.social
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TRAstonDrs @castltrastondrs.medsky.network · 27/11/2025
@dbkell.bsky.social et al www.sciencedirect.com/science/arti... www.sciencedirect.com/science/arti... link.springer.com/article/10.1... www.sciencedirect.com/science/chap... www.sciencedirect.com/science/arti...
sciencedirect.com
Long COVID: pathophysiological factors and abnormalities of coagulation
Acute COVID-19 infection is followed by prolonged symptoms in approximately one in ten cases: known as Long COVID. The disease affects ~65 million ind…
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Treaty of Westphalia @twestphalia.bsky.social · 28/10/2025
Veronica's poem will resonate with pts trapped in their ME cage, yearning to escape pain & to live a little. @fatigatioev.bsky.social @broadwaybabyto.bsky.social @erinraeburn.bsky.social @annabookwriter.bsky.social @bettinagrande.bsky.social @dbkell.bsky.social @jefflubellc19.bsky.social
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Sarah Murphy @13sarahmurphy.bsky.social · 27/10/2025
If *anyone* still thinks this grifting, piss-taking, moneyed spiv and his grifting, piss-taking, moneyed spiv mates are in this for them, then they need to be sent this. Every day. Farage is literally laughing his way to the bank and betraying this country as he goes.
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Led By Donkeys @ledbydonkeys.org · 27/10/2025
Farage: epic grifter
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Douglas Kell @dbkell.bsky.social · 17/10/2025
Assessing the Health and Functionality of the Microcirculation Using Thermal Imaging. Preprint with @resiapretorius www.preprints.org/manuscript/2... #preprints via @Preprints_org #TeamClots
preprints.org
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We Own It @weownit.org.uk · 10/10/2025
🚨Urgent: Thames Water want permission from Ofwat to ILLEGALLY pollute rivers and seas until 2040. 🤮They want your bills to fill their pockets with gold, while they fill your rivers with sewage. ✍️Sign now. Tell Ofwat to say NO to Thames Water before Tuesday 21st October.
weownit.org.uk
Thames Water want to pollute illegally until 2040. Ofwat must say NO.
Thames water want to make at deal with Ofwat, to pollute illegally for 15 years
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Douglas Kell @dbkell.bsky.social · 21/08/2025
#tinnitus is a frequent symptom for #pwLC, #pwME and others. @resiapretorius.bsky.social and I think the evidence is strong (and self-consistent) that it is often caused by #microclots and summarise it at www.preprints.org/manuscript/2... #TeamClots
preprints.org
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Douglas Kell @dbkell.bsky.social · 20/08/2025
May be of interest to #pwLC and #pwME www.youtube.com/watch?v=H-NX... #TeamClots
youtube.com
"Get rid of the microclots" | Will 2 Win: Overcoming Long COVID with Jillian Angeline
YouTube video by Jillian Angeline
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TRAstonDrs @castltrastondrs.medsky.network · 19/08/2025
#Medsky🧪 #IDsky #Immunosky #publichealth Recent research has shown that human plasmacytoid dendritic cells (pDCs) have been altered by #SARSCoV2 🦠This could have implications for both viral persistence and the development of #LongCOVID, with the Omicron subvariants having a more prominent effect.
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Douglas Kell @dbkell.bsky.social · 14/08/2025
New preprint with @resiapretorius.bsky.social showing the amyloidogenic potential of the proteome of thrombi in various embolisms and atherosclerotic plaques. #TeamClots www.preprints.org/manuscript/2...
preprints.org
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Douglas Kell @dbkell.bsky.social · 05/08/2025
My chum reminds me: "The England India cricket series was a day longer than Liz Truss's premiership in duration (46 days from start to finish). Far more enjoyable, exciting, happy and socially more cohesive." Too right.
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Tania J. Spencer @taniaspencer.bsky.social · 27/07/2025
1/ Many of us who developed #LongCOVID in the first wave in 2020, noticed an abrupt change in our nails - @resiapretorius.bsky.social Via @dbkell.bsky.social www.preprints.org/manuscript/2...
preprints.org
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TRAstonDrs @castltrastondrs.medsky.network · 29/07/2025
Recap A Perspective on How Fibrinaloid Microclots and Platelet Pathology May be Applied in Clinical Investigations @dbkell.bsky.social et al www.thieme-connect.com/products/ejo... @davidjoffe64.bsky.social et al pmc.ncbi.nlm.nih.gov/articles/PMC...
(A to F) Whole blood scanning electron microscopy of micrograph data previously collected in published studies. (A) A few plasma deposits are discernible within the blood sample of a healthy participant 173
; (B) systemic lupus erythematosus174; (C and D) acute
COVID-19 during the initial wave in 202030; (E) rheumatoid Arthritis;
(F) Alzheimer's-type disease.
176COVID-associated endothelial dysfunction and endothelialitis. Schematic representation of COVID-associated ED and endothelialitis. (1) Under pathological conditions, Type I and Type II endothelial activation—together with endothelial cell injury, such as endothelial cell apoptosis and necrosis—are all involved in ED. 39 (2) Endothelial activation promotes the production of various cytokines, chemokines, and other biomolecules that are involved in coagulation and the immune response. 40 (3) Viral persistence may contribute to ongoing endothelial inflammation or ED in Long COVID. 87 88 (4) After invasion of the endothelial cells by the virus, P-selectin, TF, ICAM1, VCAM1, and PAI-1 are expressed on these cells and ultra-large VWF multimers are also released. 58 (5) The downregulation of ACE2 favors ED 39 135 136 137 and leads to (6) a dysregulated local RAS with increased levels of Angiotensin II. 55 (7) Capillary rarefication (indicating an inflammatory response) has also been noted in patients suffering from Long COVID. 30 (8) Platelet hyperactivation is a key feature of a hypercoagulable state and has also been noted as a prominent feature in the pathobiology of acute infection 68 69 and Long COVID. 71 Created with BioRender.com. ACE2, angiotensin-converting enzyme 2; COVID-19, coronavirus disease 2019; ED, endothelial dysfunction; ICAM1, intercellular adhesion molecule 1; PAI-1, plasminogen activator inhibitor 1; RAS, renin–angiotensin system; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; TF, tissue factor; VCAM1, vascular cell adhesion molecule 1; VWF, Von Willebrand factor.
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Douglas Kell @dbkell.bsky.social · 01/08/2025
Pleased to see our paper on #preeclampsia and cell #senescence and seeming prevention by #ergothioneine is now published, with @resiapretorius.bsky.social @louiseckenny.bsky.social @lorenkell.bsky.social @themoorelab.bsky.social and others doi.org/10.1016/j.jr.... Hope we can get RCTs done now.
doi.org
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