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Dr David Joffe MB BS(Hons), PhD, FRACP

@davidjoffe64.bsky.social
13K followers 531 following 4.8K posts

Respiratory and Sleep Medicine Neurobiology and Long Cövid Vice President of ISLC & PAIS

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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 15h
doi.org/10.3390/path...
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 29/09/2026
link.springer.com/article/10.1...
link.springer.com
Health-related quality of life in IBD patients with long COVID under China’s normalized COVID-19 management - BMC Infectious Diseases
Introduction Although the COVID pandemic has gradually subsided, many patients have experienced complicated long-term symptoms, collectively known as “long-COVID”, which is commonly associated with pe...
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 29/09/2026
Adebisi et al. Tropical Medicine and Health (2026) 54:214 doi.org/10.1186/s411...
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 27/09/2026
🧠 Daily Feed of Brain Damage 🧠 Part 2 The gift that keeps giving 👀 doi.org/10.1038/s415...
doi.org
Posthospitalization COVID-19 cognitive deficits at 1 year are global and associated with elevated brain injury markers and gray matter volume reduction - Nature Medicine
A national prospective study of patients requiring hospitalization for COVID-19 demonstrates global cognitive deficits at 1 year, associated with elevated brain injury markers and reduced gray matter ...
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 27/09/2026
You're absolutely right, Steve🙏🏻😊 My apologies... The puppies were having a bath... Chaos ensued 😂😂
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 27/09/2026
Shit‼️ My BAD🤦🏻‍♂️ Take ...#2 www.mdpi.com/2077-0383/15...
mdpi.com
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 27/09/2026
🧠 Daily Feed of Brain Damage 🧠 In case you're wondering why people have "attitude" and anger issues 😳 doi.org/10.3390/neur...
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 27/09/2026
Useful paper. Consider hypocarbia when you see POTS. At least it's a treatment responsive cause of breathlessness👍🏻 www.mdpi.com/2077-0383/15...
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 26/09/2026
And then.... There's Measles 🤦🏻‍♂️ doi.org/10.1016/j.ce...
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 24/09/2026
Metabolic derangement following acute infection... Possibly a predictor of LC going forward. Only COVID causes Long C-19 doi.org/10.1016/j.di...
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 23/09/2026
Things that don't improve over time pubs.rsna.org/doi/10.1148/...
pubs.rsna.org
Five-year Quantitative Chest CT and Hyperpolarized Xenon 129 Ventilation MRI Findings in Survivors of COVID-19 Pneumonia | Radiology
Five years after COVID-19 pneumonia, some survivors showed persistent respiratory symptoms, abnormal diffusion capacity, and ventilation defects, with stabilization of pulmonary function and chest ...
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 22/09/2026
Elegant study from @profmarkfaghy.bsky.social and his outstanding Team.... Now in ink🖋😎 doi.org/10.1093/oxfi...
doi.org
An Open-Label Feasibility Study of Remdesivir in Long COVID: Results from the ERASE LC Trial
AbstractObjective. Treatment of acute COVID-19 with anti-viral and immunomodulator medications demonstrates a reduced risk of long-term outcomes. To date,
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 21/09/2026
When you don't bother with precautions in Health Care doi.org/10.1002/ajim...
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 21/09/2026
🧠 Daily Feed of Brain Damage 🧠 doi.org/10.1016/j.yn...
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 19/09/2026
Clever little virus www.science.org/doi/10.1126/...
science.org
Secreted ORF8 reprograms macrophages to enhance SARS-CoV-2 infection of lung epithelial cells
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) primarily targets the respiratory epithelium, yet severe disease features diffuse lung injury and hyperinflammatory syndromes driven by dys...
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 17/09/2026
Without comment 👇🏻👇🏻
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 15/09/2026
doi.org/10.1183/2312...
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 10/09/2026
Link to the paper, @thecovidinfoguy.bsky.social 🧠 Daily Feed of Brain Damage 🧠 www.sciencedirect.com/science/arti...
sciencedirect.com
Increased phosphorylated tau (pTau-181) is associated with neurological post-acute sequelae of coronavirus disease in essential workers: a prospective cohort study before and after COVID-19 onset
The COVID-19 pandemic led to a spectrum of post-acute sequelae including several neurological complications including cognitive dysfunction labelled N…
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 08/09/2026
And whilst we're on the subject: doi.org/10.1093/cerc...
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 08/09/2026
Some things in Neurobiology are just... Well... 😎‼️ How certain types of memory work. www.science.org/doi/10.1126/...
science.org
Storage of Spatial Information by the Maintenance Mechanism of LTP
Analogous to learning and memory storage, long-term potentiation (LTP) is divided into induction and maintenance phases. Testing the hypothesis that the mechanism of LTP maintenance stores information...
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 08/09/2026
😂😂👌🏻
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 05/09/2026
Well worth a read... Sleep restriction is not the same as sleep fragmentation or sleep deprivation... Sleep loss is many things Start here 🏁 doi.org/10.3389/fnag...
doi.org
Frontiers | Acute total sleep deprivation transiently increases plasma total tau but not plasma P-tau181 in healthy adults
BackgroundSleep deprivation is a modifiable risk factor for Alzheimer’s disease (AD). Plasma amyloid-β (Aβ) and phosphorylated tau (P-tau) are closely relate...
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 02/09/2026
It was a name chosen to respect LC It's the Title Name But... It would be disrespectful and indecent to push MECFS aside They were the loudest voices of support for early Long-Haulers They too have much to teach Medicine and Allied Health
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 01/09/2026
From being demonized a few years ago... To this! doi.org/10.1002/alz....
doi.org
Hormone replacement therapy and dementia risk among postmenopausal women: Identifying responsive subgroups in the UK Biobank
INTRODUCTION Modifiers of the association between hormone replacement therapy (HRT) use and dementia risk and responsive subgroups, are unknown. METHODS In 183,450 postmenopausal women from the UK ...
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 01/09/2026
Thank you.... I'm so upset with myself for losing my shit... I'm disappointed that I allowed myself to be baited so easily. I appreciate that people are prepared to share some forgiveness. It means a lot right now 💖🙏🏻
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 01/09/2026
Filed Under: Albo Pty Ltd... Again unable to join the dots‼️
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 01/09/2026
The dramatic reduction in Dementia from the Shingrex vaccine is simply startling, @broadwaybabyto.bsky.social The finding sheds new light upon the likely aetiology of some dementias. So much for those Pox Parties of yesteryear 😳
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 01/09/2026
"Failure by Design" @michael-hoerger.bsky.social Sadly, Australia has almost zero eyes on levels of Cövid or much else really Politicians have smothered their mistakes. @joho.bsky.social is so right about so much 😪
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 01/09/2026
Oh My Goodness 😳😳 The world has gone crazy 😪💔
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Reposted by Dr David Joffe MB BS(Hons), PhD, FRACP
Jonathan Howard @joho.bsky.social · 31/08/2026
Jay bhattacharya called for herd immunity via natural immunity. He hides it now, but he didn’t in 2020. Neither should journalists.
sciencebasedmedicine.org
How Journalists Enable the COVID Amnesia Project
People need to know the past credibility of our medical leaders to accurately gauge their current credibility.
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 31/08/2026
That means a great deal 😎🙏🏻 I should NEVER have let my jetlag and anger mix.
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 31/08/2026
I too great for their futures!! The pitting of the MECFS versus Long Covid patient groups seems rather politically designed to harm both camps and thus deny funding for research and support for both This all rather suits those responsible for the mess in which we've found ourselves
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 31/08/2026
Perhaps they ought to consider the staggering effects of Covid infections on Deep Sleep and the rising incidence of REM Behaviour Disorder? The session in Amsterdam was, too day the least... Very disturbing
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 31/08/2026
Glad to see that important accounts are over here on Bluesky 👍🏻 @doritreiss.bsky.social The teller of so many ugly truths 💔
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 31/08/2026
Thank you, My Friend 😊🙏🏻 I really ought to have behaved better, but the toxicity was simply overwhelming.... There's something deeply concerning about this specific group of accounts. The animosity towards those publishing and calling for research and treatments is disturbing to day the least
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 31/08/2026
What a poignant observation‼️ The ground seemed to really shift towards harassing the science and medical people in the LC space around 9 months ago. The meeting in Amsterdam and launch of the ISLC & PAIS has lit a real fuse... That's the bit I cannot fathom
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 31/08/2026
Seems the same trolls live here too
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 31/08/2026
Thank you.... That means a great deal art this moment 😊💝🙏🏻
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 30/08/2026
It was more than a slip I called them what they actually are These aren't genuine LC patients, they are a nest of malicious haters looking to cause as much damage as possible They don't have solutions, just coordinated malice I ought to have known better. But I was jetlagged and really hurt
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 30/08/2026
Now I know why everyone left Twitter... What an awful place to try and shared science and help people... @toshiakima.bsky.social you were right!
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 29/08/2026
A privilege to have been invited to be on the Organising Committee... An even greater honour to have spent so much time with the serious adults in this complicated space Never imagined I would be doing science and making a difference, no matter how small, to the narrative of this disease 😊🙏🏻
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 29/08/2026
Kids‼️
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 29/08/2026
Art from the Kind Corner of the Auditorium.... I simply have book words 💔💔😪
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 29/08/2026
Truly.... The speed with which the science has exploded is extraordinary‼️ I cannot recall any disease being so scrutinized at such depth and breadth in so short a time
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 29/08/2026
This was both fascinating and deeply alarming
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 29/08/2026
Folks this is a great place to start 👇🏻👇🏻👇🏻👇🏻 online.flippingbook.com/view/6349601...
online.flippingbook.com
ISLC-PAIS Conference 2026 – Abstract Book
Explore the official Abstract Book of the ISLC-PAIS Conference 2026 in Amsterdam, bringing together research on Long COVID, ME/CFS and other post-acute infection syndromes (PAIS). Featuring keynote an...
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 29/08/2026
I was fortunate enough to chair this session I would strongly recommend people follow this work closely The defining slide demonstrates even those without LC have proteinomic signatures of damage persisting at 3 years. There's also a fascinating drug repurposing study underway
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 28/08/2026
When you're being targeted... Despite masking... And vacuous lonely folks want to bash someone... It's pause for thought and a serious question.... Please post your most recent peer reviewed paper and tell me please how you cured Long C-19
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 28/08/2026
If you're fixated upon a single pathway to explain Long C-19??? Think again If you're convinced you've solved the riddle... You've only entered the maze William Osler: the father of observational medicine and the true Art of the Clinician... Said it best
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Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 28/08/2026
Apologies for being MIA... The Amsterdam Meeting has consumed my time for several days Regardless of the vicious and deliberate targeting of this amazing meeting from the ugliest side of X-shit, the science has been extraordinary I will hopefully post the best of what I've seen soon as possible
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