iiinova — where your digital self keeps evolving

David Suter @davidsuter.bsky.social · 18/09/2026

In Switzerland trains are absolutely awesome ! Mostly on time or with small delays, drive you virtually anywhere - including to the mountains

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Admirable Women @admirablewomen.bsky.social · 16/09/2026

#Music teacher, conductor & composer Nadia Boulanger is regarded as the most influential music pedagogue of the 20th century. Shattered glass ceilings by becoming the first woman to conduct the Boston Symphony Orchestra, NY Philharmonic & the Royal Philharmonic Society in London. #MusicSky🧵

A dramatic black-and-white photograph of Nadia Boulanger (September 16, 1887 – October 22, 1979) conducting the orchestra of the Royal Philharmonic Society during a rehearsal at Queen’s Hall in London. The legendary French composer, conductor, and teacher is captured in a powerful, commanding pose from a lower angle. She stands behind a conductor's music stand holding open scores, with both arms raised high against a stark, solid black background. Her face is illuminated by a sharp overhead spotlight, emphasizing her stern, intensely focused expression and clear, round eyeglasses. She wears a simple, long-sleeved dark silk or satin dress with a V-neckline, adorned with a delicate starburst pendant necklace. Her hands are expressive and deliberate: her left index finger points dramatically upward toward the ceiling, while her right hand is held slightly lower, fingers curled mid-gesture. The stark, high-contrast composition isolates her figure, creating a deeply intense, artistic, and reverent mood. This photograph captures an immense moment of historical significance, illustrating the fierce focus of one of the most influential music educators and female conductors of the 20th century.

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David Suter @davidsuter.bsky.social · 02/09/2026

Sounds very exciting - for sure my own ignorance, but I cannot help being surprised that in some fields, N=1 --> big splash. In mine, N=1 --> ...most likely an artifact.

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Erik van Nimwegen @erikvannimwegen.bsky.social · 21/08/2026

Remember this? bsky.app/profile/did:... Rigorous visualization of the structure in your high-dimensional data. Fantastic work by @dhdegroot.bsky.social With help of the reviewers of Nat Biotech it is now updated, extended an officially published here: www.nature.com/articles/s41... 1/n

nature.com

Bonsai reconstructs tree representations for distortion-free visualization and exploration of high-dimensional data - Nature Biotechnology

High-dimensional data are visualized through representation on tree structures.

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David Suter @davidsuter.bsky.social · 21/08/2026

Looks amazing Erik ! We are excited to try it on our data.

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Miki Ebisuya @ebisuyamiki.bsky.social · 13/08/2026

New paper from the lab! authors.elsevier.com/sd/article/S... We find that protein degradation is broadly slower in human segmentation clock cells than in mouse cells, regardless of the degradation pathway or protein category! 1/

authors.elsevier.com

Systematic differences in protein stability underlie species-specific developmental tempo

Human embryonic development proceeds more slowly than in mice. The segmentation clock offers a tractable model for studying species-specific developme…

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David Suter @davidsuter.bsky.social · 07/07/2026

Leurs frites sont nettement meilleures en plus

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David Suter @davidsuter.bsky.social · 03/07/2026

Maybe mine is an unpopular opinion, but I think the question asked in this Nature piece is not a good one. Because it insinuates that time spent in the lab is the n°1 limiting factor. It is one of course, but not the main one - careful thinking and planning are way more important.

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David Suter @davidsuter.bsky.social · 27/06/2026

Very much enjoyed this preprint - getting closer to a quantitative understanding on how promoter/enhancer interactions drive transcriptional activity: www.biorxiv.org/content/10.6...

biorxiv.org

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David Suter @davidsuter.bsky.social · 25/06/2026

This also reflects my experience is with Q.E.D reviews - a very good one precisely because it pointed us at weaknesses stemming from technical/statistical aspects, but staying away from judging conceptual novelty, etc. Conveying more clearly in what sense some papers are "top 1%" would be great.

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David Suter @davidsuter.bsky.social · 25/06/2026

the readers can check themselves. But then how important a given discovery is for a field and beyond is by definition out of reach for current AI in its current state. I am afraid that in the very best case, AI will sound like an old grumpy scientist entrenched in their own convictions.

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David Suter @davidsuter.bsky.social · 25/06/2026

I think the limits of these assessments should be very clearly stated. There is most likely value for AI to assess the robustness of the results obtained when the techniques used are well-established, with clear quality controls, based on hard numbers, stats, and summarizing this so that...

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David Suter @davidsuter.bsky.social · 23/06/2026

What a tour-de-force ! Makes me think that the mechanisms enhancer-mediated transcriptional activation are now truly falling into place

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David Suter @davidsuter.bsky.social · 21/06/2026

Q.E.D. 🤦‍♀️🇨🇭🤦‍♂️

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David Suter @davidsuter.bsky.social · 16/06/2026

Non-science post: join us in beautiful Cully for the Lavaux Festival www.lavauxclassic.ch ! I will play along with many other laureates of the Lavaux piano competition - concert will take place outside on the lake shore, free entrance, three hours of music, Saturday June 20, 13:00 to 16:00 🎹 🎶

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Pablo Navarro @pablonavarrolab.bsky.social · 03/06/2026

Epigenetics means different things for different people. In this workshop we will discuss two major views anchored on transcriptional memory: chromatin vs networks. Come and share with us our excitement for the topic and the magnificent place, the Andalusian Baeza. urldefense.com/v3/__https:/...

urldefense.com

Workshop Transcriptional memory in health and disease

The idea that cells remember past states to prepare their future endeavors has split into two parallel languages that rarely converse. On one side, chromatin epigenetics defines inheritance through th...

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Oded Rechavi @odedrechavi.bsky.social · 10/06/2026

"The Case for a Validity Layer in Life Science Research" - a very interesting article by Meir Maor, QED's CTO. Meir explains why biology is harder for AI than mathematics. www.qedscience.com/blog/life-sc...

qedscience.com

The case for a validity layer in life science research

When OpenAI recently announced that one of its models had disproved a long-standing conjecture in discrete geometry, the scientific community took notice...

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Austin Smith @ausmith.bsky.social · 09/06/2026

Postdoc position available now in the Smith Group lsi.exeter.ac.uk/groups/smith... to test the hypothesis that differentiation biases between human pluripotent stem cell lines may be eliminated by reversion to the naïve state. careers.exeter.ac.uk/vacancies/79...

lsi.exeter.ac.uk

Smith Group - Living Systems Institute - University of Exeter

Understanding pluripotency

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Rob Klose @robklose.bsky.social · 29/05/2026

Help please! We need to do some large(ish) cell culture inhibiting E-cadherin with a monoclonal antibody. Does anyone have the DECMA-1 hybridoma cell line so we could purify our own antibody? or a similar monoclonal that would do the job. Any help greatly appreciated, just DM me. Please repost!

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David Suter @davidsuter.bsky.social · 23/05/2026

I hope the absurdity of it all will at some point abolish the concept of grant - and funding will simply be allocated by institutions, maybe with extra money when a lab overperforms.

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David Suter @davidsuter.bsky.social · 12/05/2026

Congrats Elias ! Happy to see this out 👏🥳

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David Suter @davidsuter.bsky.social · 08/05/2026

Big 🙏 to everyone involved, first to fantastic Joanna Dembska who put so much hard work into this project, to AL Mahul-Mellier for the beautiful work on the PD disease models, and to the EPFL bioimaging, proteomics, genomics, & biomolecular screening facilities.

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David Suter @davidsuter.bsky.social · 08/05/2026

How do these compounds act ? Despite the fact that their known cellular targets are all different from each other, we found that all three compounds converged on inducing an increase in ribosomal protein expression, suggesting that enhancing protein synthesis may in turn stimulate protein turnover.

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David Suter @davidsuter.bsky.social · 08/05/2026

human models of alpha-synuclein mediated protein aggregation (model of Parkinson's disease). All 3 compounds were able to strongly reduce the formation of pathological fibrils in mouse neurons, and one was also potent in human ES cell-derived dopaminergic neurons...

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David Suter @davidsuter.bsky.social · 08/05/2026

and is involved in the formation of toxic aggregates. Joanna screened for nearly 6000 compounds, and found nearly 200 compounds increasing turnover in human neurons. After narrowing down the list, she focused on three compounds that were further tested by Anne-Laure Mahul-Mellier in mouse and...

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David Suter @davidsuter.bsky.social · 08/05/2026

📢 New preprint alert ! www.biorxiv.org/content/10.6... Joanna Dembska developed a highly scalable image-base screening platform for protein turnover modulators in human neurons, based on our fluorescent timer system. Protein turnover is perturbed in nearly all neurodegenerative diseases ...

biorxiv.org

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MC Gambetta @mcgambetta.bsky.social · 04/05/2026

Hello all, our lab is recruiting a PhD candidate to study how 3D genome folding impacts gene regulation in development. We're located at the Center for Integrative Genomics department of the University of Lausanne, Switzerland. Please email me if interested. #PhDPosition, #PhDOpportunity

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Anna Mazzola @annamazz.bsky.social · 01/05/2026

Some useful public speaking tips from Freud here.

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David Suter @davidsuter.bsky.social · 24/04/2026

It would be nice to see drug synchronization-free approaches being more universally used to study these questions - with the ever-increasing sensitivity of omics approaches, there is no reason why not to get there soon.

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David Suter @davidsuter.bsky.social · 24/04/2026

I do understand that many things are difficult to do without strong mitotic synchronization, but still I feel this is a major problem in the field. We have been trying to address this issue www.sciencedirect.com/science/arti...

sciencedirect.com

Orchestration of pluripotent stem cell genome reactivation during mitotic exit

Cell identity maintenance faces many challenges during mitosis, as most DNA-binding proteins are evicted from DNA and transcription is virtually aboli…

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David Suter @davidsuter.bsky.social · 24/04/2026

If acetylation is artificially gone after nocodazole treatment, how can we interpret results from nocodazole-treated cells, looking at genome reactivation during early G1 ? I mean histone acetylation is mostly gone because of the drug, so obviously this will alter transcriptional reactivation.

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David Suter @davidsuter.bsky.social · 24/04/2026

Very nice work on histone modifications of mitotic chromosomes ! And also points at issues working with nocodazole-mediated synchronization, which still so many labs use - this work here shows how it artificially results in loss of mitotic histone acetylation. www.cell.com/molecular-ce...

cell.com

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David Suter @davidsuter.bsky.social · 19/04/2026

I am not surprised since the SNSF also took similar measures - seems to be seen as the less damaging way to deal with budgetary restrictions. Very annoying, but in the end we should blame the angry little white men in charge of certain large countries and the systems allowing them to stay in power

a.in

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David Suter @davidsuter.bsky.social · 10/04/2026

Congraaaats Can ! Your passion for science paid off nicely with this beautiful piece of work !

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Benjamin Towbin @betowbin.bsky.social · 08/04/2026

Join us at the LS2 #Theory #across #Biology chalk talk symposium! 12 June 2026 in Bern, CH. @lifesciswitzerland.bsky.social No movies that fail, no Mac to PC issues. Only the best ideas and exchange across biology from evolution and ecology to physics of life. meetings.ls2.ch/theory-acros...

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Sasha Gusev @sashagusevposts.bsky.social · 01/04/2026

Monthly median Received to Accepted time (days) at Nature Genetics

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David Suter @davidsuter.bsky.social · 31/03/2026

That’s a killer argument, how could one imagine cycling without eating

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Oded Rechavi @odedrechavi.bsky.social · 30/03/2026

Do we grow wiser as we age? I spent 15+ years chasing glam journals, wasting time and energy (and frustrating my team and co-authors). I don’t want to wake up at 70 and realize my life went into convincing a few editors my work was trendy enough. Enough. I’ll try to be smarter.

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David Suter @davidsuter.bsky.social · 30/03/2026

Non-science post - Any plans for Easter ? If not, come join us in Evian 🇫🇷 on 4.4. for the piano marathon ! My menu: Brahms : Rhapsodie op.79 n°1, Schumann : 2 pieces from Fantaisiestücke op. 12, Chopin : Ballade n°4 & Mazurka op.59 n°2 info 👇 marathondupiano.com www.youtube.com/watch?v=ya7M...

youtube.com

Teaser - Concert Evian

YouTube video by David Suter

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David Suter @davidsuter.bsky.social · 26/03/2026

Email spam in 2026 is so out of control that it feels like smashing nagging mosquitoes on a hot summer night

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David Suter @davidsuter.bsky.social · 20/03/2026

Yep, we also encountered the same issues - motif of the TF we ChIP only showing up in 30-40% of peaks, and other TF motifs - typically Klfs that are biased towards promoters - showing up more frequently

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David Suter @davidsuter.bsky.social · 20/03/2026

Yes ! But still, I am worried that the approaches most of us are using are even further from providing realistic, quantitative maps of where TFs bind in the genome than we previousy thought

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David Suter @davidsuter.bsky.social · 20/03/2026

Also the very strong discrepancy with ChIP-seq and CUT&RUN is rather sobering to the field

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