The authors report surprising covariations between subthreshold activity of single V1 neurons and behavior, demonstrating that interactions between external sensory inputs and internal states are impl...

Abstract. Originally proposed as a conceptual metaphor, the Waddington landscape was used to illustrate the directional nature of embryonic development and

Recurrent neural networks (RNNs) provide a theoretical framework for understanding computation in biological neural circuits, yet classical results, such as Hopfield's model of associative memory, rel...

People with aphantasia are offering a window into consciousness.

Low-dimensional representations of functional brain anatomy relevant for dementia syndromes may exist. Here the authors propose a computational model of mental functions to catalogue this anatomy in A...

The hippocampus is a cognitive hub whose functions are disrupted in most major neurodegenerative dementias. Despite substantial knowledge of its anatomy, physiology, and circuitry, a unifying account ...

“Streets of Minneapolis” names Renée Good and Alex Pretti, and excoriates “King Trump.”

In the nucleus accumbens, acetylcholine boosts dopamine release to promote effortful behaviour.

Spatial attention supports navigation by prioritizing information from selected locations. A candidate neural mechanism is provided by theta-paced sweeps in grid- and place-cell population activity, which sample nearby space in a left-right-alternating pattern coordinated by parasubicular direction signals. During exploration, this alternation promotes uniform spatial coverage, but whether sweeps can be flexibly tuned to locations of particular interest remains unclear. Using large-scale Neuropixels recordings in freely-behaving rats, we show that sweeps and direction signals are rapidly and dynamically modulated: they track moving targets during pursuit, precede orienting responses during immobility, and reverse during backward locomotion — without prior spatial learning. Similar modulation occurs during REM sleep. Canonical head-direction signals remain head-aligned. These findings identify sweeps as a flexible, attention-like mechanism for selectively sampling allocentric cognitive maps. ### Competing Interest Statement The authors have declared no competing interest. European Research Council, Synergy Grant 951319 (EIM) The Research Council of Norway, Centre of Neural Computation 223262 (EIM, MBM), Centre for Algorithms in the Cortex 332640 (EIM, MBM), National Infrastructure grant (NORBRAIN, 295721 and 350201) The Kavli Foundation, https://ror.org/00kztt736 Ministry of Science and Education, Norway (EIM, MBM) Faculty of Medicine and Health Sciences; NTNU, Norway (AZV)

Biological Brains Inspire a New Building Block for Artificial Neural Networks on Simons Foundation

NotebookLM explains StateViewer, FDG-PET, and SLOD

NotebookLM explains StateViewer, FDG-PET, and SLOD