As a Postdoctoral Associate in the Barisic Lab at Weill Cornell Medicine, you will work on projects focused on how chromatin remodeling complexes and 3D genome organization regulate cell differentiati...

By mapping SWI/SNF complex subfamilies in the melanocytic lineage, Grossi and Nguyen et al. find that PBAF-only sites harbor PRC1/2 modifications and the repressive transcription factor REST. PBAF is ...

Studying the functional consequences of structural variants (SVs) in mammalian genomes is challenging because (i) SVs arise much less commonly than single-nucleotide variants or small indels and (ii) ...

We developed PRINT, a computational method that identifies footprints of DNA–protein interactions from bulk and single-cell chromatin accessibility data across multiple scales of protein size.

Gene expression is coordinated by a multitude of transcription factors (TFs), whose binding to the genome is directed through multiple interconnected epigenetic signals, including chromatin accessibil...

Isshiki et al. demonstrate that EZH2 inhibitors re-activate immune synapse functions between B cell lymphomas and T cells, sensitizing lymphomas to T cell immunotherapies. EZH2 inhibition enhances killing activity by promoting T cell recruitment, prolonging binding and increasing contact surface with lymphoma cells, and prevents T cell exhaustion. This strategy is currently under clinical evaluation.

A eukaryotic histone complex can package DNA but is also a cupric reductase that provides biousable Cu1+ for the cell.

Single-cell Proliferation Rate Inference in Non-homogeneous Tumors through Evolutionary Routes (SPRINTER) allows users to infer proliferation rates of individual clones within a tumor from single-cell...

ChIP-DIP (ChIP done in parallel) is a highly multiplex assay for protein–DNA binding, scalable to hundreds of proteins including modified histones, chromatin regulators and transcription factors, offe...

A study uses single-molecule footprinting to measure protein occupancy at regulatory elements on individual molecules in human cells and describes how different properties of transcription factor bind...

Here, the authors show that the canonical BRG/BRM-associated factor (SWI/SNF) chromatin remodeler generates subnucleosomes containing 50–80 bp of DNA associated with the four core histones. These hemi...

Cryo-electron microscopy and biochemical studies elucidate the read–write mechanisms of non-canonical PRC1-containing RYBP in histone H2A lysine 119 monoubiquitination and their roles in maintaining e...

Nucleosome flipping mediates a proofreading and processive mechanism of histone exchange driven by the chromatin remodeller SWR1.

By developing a long-read sequencing method to simultaneously map replication status and protein-DNA contacts in cells, Ostrowski, Yang, et al. show that newly replicated chromatin is enriched for unw...