Treatment of induced pluripotent stem cells with Norrin and vitronectin, and subsequent cell sorting and maturation, generates retinal-like endothelial cells that can regenerate retinal vasculature in an oxygen-induced retinopathy mouse and recapitulate enhanced inner blood–retinal barrier properties when co-cultured with retinal-like pericytes.

The STED-EC atlas enables inter-organ and multi-time-point comparisons of gene expression in endothelial cells, revealing substantial transcriptomic variations across endothelial cells from different embryonic organs and facilitating investigation of previously unknown molecular mechanisms that govern organ-specific vascular development.

In vivo loss-of-function CRISPR screens were performed to identify genes influencing CAR T cell persistence and function in human multiple myeloma, highlighting CDKN1B as a promising target.

Kim et al. map gene regulatory networks of the developing mouse hypothalamus and prethalamus using single-cell multiomics, identifying regulators of regionalization and neurogenesis. They further show...

Postdoctoral Associate- Human Genetics

Thousands of neurodevelopmental disorder (NDD)-associated genes remain undiscovered, limiting genetic diagnoses. Here, we employ inheritance-specific machine learning models, incorporating gene expres...