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crismayorruiz.bsky.social

@crismayorruiz.bsky.social
519 followers 102 following 15 posts

Passionate scientist, runner, basket. Group leader at #IRBBarcelona | Targeted protein degradation | Chemical biology

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Chemical Society Reviews @chemsocrev.rsc.org · 30/07/2026
Check out "The synthetic landscape of cereblon (CRBN) binders: from thalidomide to emerging chemotypes" by Sergi Rafael, Carolina Sánchez-Zarzalejo, Rory Whelan, Clifford Harris, Xavier Verdaguer, Cristina Mayor-Ruiz and Antoni Riera Read the #OpenAccess review here 👉pubs.rsc.org/cs/arti...
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IRB Barcelona @irbbarcelona.org · 14/07/2026
A study by #IRBBarcelona & @ciccancer.bsky.social demonstrates that eliminating mutated #KRAS protein using #PROTACs induces rapid tumour regression in mouse models. ▶️ youtu.be/qZG4rTb4EIQ?si=Hn4jR5DRKj1… 📌 DOI: 10.1158/0008-5472.CAN-25-5172 #CancerResearch @crismayorruiz.bsky.social
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¿Y si el cáncer se pudiera “autodestruir”? El nuevo avance contra KRAS
La proteína KRAS llevaba décadas siendo considerada un objetivo “im...
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MS Proteomics @mspcf.bsky.social · 05/06/2026
(1/3) Exciting news! The work titled “Targeted KRASG12V Degradation in vivo Elicits Lung Adenocarcinoma Regression with Subsequent Relapse from Dysregulated Proteolysis” demonstrates that eliminating mutated #KRAS with #PROTACs induces rapid tumour regression in mouse models of lung adenocarcinoma.
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IRB Barcelona @irbbarcelona.org · 27/05/2026
📢 #KRAS degradation induces rapid lung #cancer regression in preclinical mouse models: A study by #IRBBarcelona & @ciccancer.bsky.social demonstrates that eliminating mutated KRAS protein using #PROTACs induces rapid tumour regression in mouse models of lung adenocarcinoma. ➡️ bit.ly/4dFWhm1
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Centro de Investigación del Cáncer (CSIC, USAL, FICUS) @ciccancer.bsky.social · 27/05/2026
El equipo del @ciccancer.bsky.social ( @csic.es, @usaloficial.bsky.social, FICUS), dirigido por David Santamaría, en estrecha colaboración con investigadores del @irbbarcelona.org, han desarrollado un modelo preclínico de cáncer de pulmón en ratón.
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crismayorruiz.bsky.social @crismayorruiz.bsky.social · 06/03/2026
🧪 Chem(bio) friends, this one is big!!🔥 @irbbarcelona.org is opening a Group Leader position in Chemical Biology! 💜 If your research plan and vision are at the interface of synthetic chemistry, chemical biology, and biomedicine, please check the call! 👇 recruitment.irbbarcelona.org/jobs/7334978...
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Nezha Benabdallah @nsbenab.bsky.social · 28/01/2026
SS18::SSX activates Polycomb target genes without BAF ❌ Instead, transcription relies on EP300 via the SS18 QPGY domain www.biorxiv.org/content/10.6... ➡️ Coactivator targeting emerges as a new therapeutic strategy in synovial sarcoma 🎯 Team work from @banitolab.bsky.social and @uoe-igc.bsky.social
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IRB Barcelona @irbbarcelona.org · 21/08/2025
🤝 #IRBBarcelona Group Leader Cristina Mayor-Ruiz has co-authored a Perspective in #MolecularCell proposing the creation of a #EuropeanAlliance to accelerate the development of proximity-induced therapies. More information here 🔗 www.irbbarcelona.org/en/news/scie... 🧪 #TargetedProteinDegradation
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IRB Barcelona @irbbarcelona.org · 25/07/2025
📷 Photo 51 — the image that changed the course of science. Taken by British chemist and crystallographer #RosalindFranklin (born on this day in 1920) and Raymond Gosling, this X-ray diffraction image of DNA was the key to unlocking the double helix structure. #WomeninSTEM
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IRB Barcelona @irbbarcelona.org · 23/04/2025
🔬Check out this recent spotlight in #MolecularCell, co-authored by Rory Whelan Ferran José Duran & @crismayorruiz.bsky.social— Mutations that stick: Unexpected discovery of molecular glue mimicry👇  ➡️ f.mtr.cool/zbljytwpcx #ChemBio #MolecularGlue #MolecularGlues 🧪
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crismayorruiz.bsky.social @crismayorruiz.bsky.social · 29/03/2025
👇🧪
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IRB Barcelona @irbbarcelona.org · 08/03/2025
🟣 On #WomensDay, we recognize the incredible women of #IRBBarcelona! Researchers, technicians, managers, and other professionals whose talent and dedication push the boundaries of knowledge. Your work fuels discovery and paves the way for future generations of women in science. Thank you! 🙌 #8M
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crismayorruiz.bsky.social @crismayorruiz.bsky.social · 02/03/2025
🧪 #Barcelona
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IRB Barcelona @irbbarcelona.org · 24/02/2025
📌 La Dra. Ana Domostegui desarrolla un nuevo tipo de fármacos innovadores, denominados fármacos degradadores de proteínas, para el tratamiento del #CáncerdePáncreas.
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IRB Barcelona @irbbarcelona.org · 24/02/2025
📌 PROTECT: En el marco de @cancergrand.bsky.social, el proyecto liderado por la Dra. @crismayorruiz.bsky.social desarrollará fármacos degradadores de proteínas para luchar contra los tumores pediátricos.
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IRB Barcelona @irbbarcelona.org · 24/02/2025
🟢 Ha sido un honor asistir hoy a la presentación de las Ayudas 2024 de la Asociación Española Contra el Cáncer. ¡Gracias Asociación Española contra el Cáncer por acompañarnos en este compromiso! Cada paso juntos nos acerca a un futuro sin #cáncer. Descubre los proyectos del @irbbarcelona.org: 🧵👇
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IRB Barcelona @irbbarcelona.org · 19/02/2025
Avui hem tingut l’honor de rebre la visita de la consellera de Salut, Dra. Olga Pané. Ha conegut de primera mà els plans de futur de l'Institut i la importància dels nous laboratoris TRIP, una innovadora forma d'apropar #recerca fonamental i clínica. Gràcies, consellera!
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IRB Barcelona @irbbarcelona.org · 25/11/2024
Hello, Blueskyers! Here's a comprehensive Starter Pack featuring all the IRB Barcelona faculty and affiliated members currently active on Bluesky. Keep an eye on this space—we'll be regularly updating it as more of our researchers join the platform. Thanks for following us! go.bsky.app/6QPdeJj
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crismayorruiz.bsky.social @crismayorruiz.bsky.social · 11/02/2025
Happy #WomenScienceDay! @irbbarcelona.org 🧪 youtube.com/shorts/p3rRs...
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🔬 Día Internacional de la Mujer y la Niña en la Ciencia | Científicas que inspiran el futuro STEM 🚀
YouTube video by IRB Barcelona
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IRB Barcelona @irbbarcelona.org · 28/01/2025
We are creating a dedicated website to honor the memory of Dr. Joan Guinovart and celebrate his remarkable legacy✨  Contribute by sharing your message through this form: ➡️ shorturl.at/YQn1l  Join us in paying tribute to his extraordinary impact.
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crismayorruiz.bsky.social @crismayorruiz.bsky.social · 09/01/2025
🧪
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crismayorruiz.bsky.social @crismayorruiz.bsky.social · 24/12/2024
Our lab wishes you all a Merry Christmas! We finish the scientific year at the @irbbarcelona.org Christmas party with the best costume ever!! 🤣🤣🤣
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crismayorruiz.bsky.social @crismayorruiz.bsky.social · 16/12/2024
Hi BlueSky world! We are thrilled to share our new preprint around oncoprotein degradation in vivo —a fantastic collaboration with our friends in Salamanca #lab_santamaria #ciccancer! 😃 @irbbarcelona.bsky.social #TPD #KRAS 👇 www.biorxiv.org/content/10.1...
biorxiv.org
Targeted KRAS(G12V) degradation elicits efficient and durable lung adenocarcinoma regression in vivo
Recent drug discovery breakthroughs led to the approval of KRASG12C inhibitors in lung adenocarcinoma (LUAD). Unfortunately, clinical responses remain limited due to rapid resistance onset. Proteolysi...
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Thorn-Seshold Lab @thornsesholdlab.bsky.social · 17/11/2024
Women in chemistry starter pack here: go.bsky.app/LjumNEg #ChemSky please repost :D #ChemSky #realtimechem #FluorescenceFriday
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Thorn-Seshold Lab @thornsesholdlab.bsky.social · 17/11/2024
📯📯 Chemical Biology starter pack 📯📯 140 PIs & groups posting primary research in chemical biology. Please reskeet (?) & reply to this post if you want to be added! go.bsky.app/KLrTWoj Let's make ChemBioSky even greater again! #realtimechem #FluorescenceFriday #chemsky #chemtwitter #AgentOrange
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Rune Busk Damgaard @rbdamgaard.bsky.social · 15/11/2024
Check out this list of ubiquitin and Ubl profiles to follow. Repost if you want me to add you to it. Let’s create a good community here ☁️ go.bsky.app/3VPQofn
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