Prof. Björn Schumacher has been nominated for the prestigious German Medical Award for his work at the CECAD Cologne Cluster of Excellence on Aging and Aging-associated Diseases. The CECAD Speaker has...

Senescence involves a massive reorganization of cellular components. This study shows that changes in ribosomal proteins and the ubiquitin-proteasome system are distinctive features of replicative sen...

Background The propensity for accumulating somatic mutations varies along the genome, which critically influences somatic mosaicism, tumor evolution and the potential role of somatic mutations in the ...

Padvitski, Unger Avila, Chen et al. introduce a single-cell transcriptomic framework that quantifies progressive cellular damage across degenerative disease models. Applied to kidney and liver injury,...

Padvitski, Unger Avila, Chen et al. introduce a single-cell transcriptomic framework that quantifies progressive cellular damage across degenerative disease models. Applied to kidney and liver injury,...

Mallik et al. discovered that peripheral neuropathy caused by mutations in YARS1 arises when mutant YARS1 protein sequesters a vital transfer RNA (tRNA), t

Inspired by long-lived animals — and human centenarians — researchers are hunting for ways to enhance DNA repair and extend healthspan.

Prolonged translational arrests caused by defective mRNAs activate the ribosome-associated protein quality control (RQC) pathway, which marks harmful incomplete proteins for degradation. Multipass tra...

CPOX is a direct substrate of the mitochondrial oxidase ALR, linking intermembrane space redox chemistry to heme biosynthesis.

Palikyras and colleagues investigate chromatin reorganization upon senescence induction, reporting that components of nuclear speckles coordinate chromatin rewiring and a senescence-associated splicin...

Human aging is a heterogeneous, multi-system process that spans molecular, tissue, and physiological decline. In this issue of Cell, Li et al. integrate clinical data, multi-omics, and organ-associate...

Conducting innovative research in line with the above-mentioned project. Collecting, analyzing, and interpreting data using various OMICs techniques. Conducting in vitro and in vivo experiments. Colla...