Bioisosteric replacement is a powerful strategy for optimizing physicochemical, pharmacological, and safety properties of drug candidates. In this article, we provide a bioisosteres cheat sheet comple...

Nature Catalysis, Published online: 31 October 2025; doi:10.1038/s41929-025-01438-yThe Heck reaction is widely used in modern organic chemistry. Here the authors provide an alternative approach to common transition-metal catalysis, leveraging access to Bi(II) species thanks to bismuth’s photophysical properties.

Cross-coupling reactions traditionally permit the formation of Ar‒Ar bonds between an aryl nucleophile and an aryl electrophile under transition metal catalysis. The high selectivity of the myriad of ...

Nature Reviews Chemistry, Published online: 13 March 2025; doi:10.1038/s41570-025-00708-4Mary Garson is an Emerita Professor of the University of Queensland and President-elect of the International Union of Pure and Applied Chemistry (IUPAC). In 2024, The…

22nd International Symposium on Organometallic Chemistry Directed Toward Organic Synthesis Kyoto, Japan, Sep 1-5, 2025

In recognition for developing activity-based protein profiling and advancing covalent drug discovery, Professor Benjamin Cravatt, PhD, the Norton B. Gilula Chair in Biology and Chemistry at Scripps Re...