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Constance Bailey

@constancebailey.bsky.social
2.7K followers 1.1K following 81 posts

#SynBio and #naturalproducts. Enzymology, heterologous expression, and bioengineering. Senior Lecturer in Chemical and Synthetic Biology at the University of Sydney .

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Constance Bailey @constancebailey.bsky.social · 22/06/2025
New preprint on conserved BCG in myxobacteria from Cole Steven's lab! www.biorxiv.org/content/10.1...
biorxiv.org
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Constance Bailey @constancebailey.bsky.social · 16/06/2025
The Extraordinary Benefit of Nature’s Chemistry to Health, Society, and the Economy | Journal of Natural Products pubs.acs.org/doi/full/10....
pubs.acs.org
The Extraordinary Benefit of Nature’s Chemistry to Health, Society, and the Economy
The connection between humans and Nature’s chemistry is astonishing and built into the very fabric of our genetic code. In this Perspective, we focus on bioactive molecules from microbes, plants, and ...
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Reposted by Constance Bailey
Carl Zimmer @carlzimmer.com · 02/05/2025
NIH is freezing funds for research abroad, threatening thousands of projects. 9/10 www.nature.com/articles/d41...
nature.com
Exclusive: NIH to suspend funds for research abroad as it overhauls policy
Move by US biomedical agency threatens thousands of projects on infectious diseases, cancer and more.
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W. Carson Byrd @wcbyrdphd.bsky.social · 02/05/2025
Important story of NSF cuts by @carolynyjohnson.bsky.social, & important perspective from @alondra.bsky.social: ‘These accounts of how we are decimating with a thousand cuts the science & research ecosystem are devastating… It’s sort of cutting off the future.’ www.washingtonpost.com/science/2025...
washingtonpost.com
Amid DOGE-induced turmoil, National Science Foundation in crisis
The $9 billion agency, which exists solely to fund researchers, projects and facilities outside its Alexandria, Virginia, headquarters, is hitting reverse on its mission.
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Max Kozlov @maxkozlov.bsky.social · 02/05/2025
Affected by the foreign subawards policy? Help run clinical trials abroad on a project with a subaward? I want to hear how this policy impacts you. Send me a message on Signal at mkozlov .01 or email me at maxkozlov [at] protonmail [dot] com. You can stay anonymous.
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Leighton Pritchard @widdowquinn.bsky.social · 28/04/2025
There's an open call for editors (5-year terms) at Applied and Environmental Microbiology, for those of you who might be interested: journals.asm.org/journal/aem/...
journals.asm.org
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Constance Bailey @constancebailey.bsky.social · 23/04/2025
If anyone has concerns, the biosecurity bureaucracy of Australia should allay them!
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Constance Bailey @constancebailey.bsky.social · 23/04/2025
I know conservation biologists have ethical concerns about Colossal Biosciences, etc., but one thing is for sure: DAFT and the OGTR are never ever going to let a GMO thylacine-like animal that is actually a GMO numbat or whatever wander the bush in Tassie.
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boehninglab @boehninglab.com · 11/04/2025
This is chilling www.fda.gov/news-events/...
fda.gov
FDA Announces Plan to Phase Out Animal Testing Requirement for Monoclonal Antibodies and Other Drugs
FDA Plans to Phase Out Animal Testing Requirement
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Constance Bailey @constancebailey.bsky.social · 11/04/2025
I injured my thumb tripping on a run this morning, and it is kinda annoying typing, but I am really glad that I am not a PhD student/postdoc anymore because pipetting would be literally impossible.
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Jordan Meier @doc-jlmeier.bsky.social · 10/04/2025
Great news: NIH postbac program is recruiting again! If your grad school plans were affected by program cutbacks or admissions freezes this year I highly encourage you to apply, this could be a perfect opportunity. Please repost. www.training.nih.gov/research-tra...
training.nih.gov
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Drug Monkey @drugmonkey.bsky.social · 09/04/2025
NSF will award ~1,000 instead of their usual ~2,000 Graduate Research Fellowships this year. NSF slashes prestigious PhD fellowship awards by half www.nature.com/articles/d41...
nature.com
NSF slashes prestigious PhD fellowship awards by half
US National Science Foundation announces lowest number of Graduate Research Fellowship Programme recipients in 15 years.
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Constance Bailey @constancebailey.bsky.social · 09/04/2025
My biggest comment on paper I am reviewing today is going to be that their technical sales pitch jargon literally makes the paper hard to follow even though it's a pretty straightforward genetic circuit.
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Constance Bailey @constancebailey.bsky.social · 09/04/2025
Not to throw rocks at glass houses (because I definitely am guilty of this) but sometimes synthetic biology is so vibey. Sometimes people are just doing a pretty basic genetic experiment and dressing it up in technical futuristic jargon.
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Constance Bailey @constancebailey.bsky.social · 06/04/2025
General vibes right now
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Constance Bailey @constancebailey.bsky.social · 04/04/2025
www.nature.com/articles/s41...
nature.com
Openness guides discovery - Nature Biotechnology
Nature Biotechnology - Openness guides discovery
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ProPublica @propublica.org · 03/04/2025
🧪 #ScienceSky and #AcademicSky: We’re trying to learn more about the real-life scope and impact of the Trump administration terminating NIH grants. Here's how you can help our reporting 👇
propublica.org
Did You Work on a Terminated NIH Grant? ProPublica Wants to Hear From You.
The National Institutes of Health is canceling grants that are seen as conflicting with the Trump administration’s priorities. We want to hear from researchers who have been affected.
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Constance Bailey @constancebailey.bsky.social · 01/04/2025
I worry about all the focus on commercialision from the ARC here in Oz for the same reason
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Constance Bailey @constancebailey.bsky.social · 31/03/2025
This came to mind after hearing recent discussions on podcasts etc. about the rise of Chinese innovation with companies like Byd and Xaomi, Byd's accession while Tesla flounders and Elon Musk is DODGE-ing, etc. China has won biotech: thehill.com/opinion/tech....
thehill.com
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ACS BIOL: Division of Biochemistry and Chemical Biology @acsbiol.bsky.social · 29/03/2025
Big ups to ACS for providing complimentary childcare at #ACSFall2025. Attending conferences is enough logistical work as-is. Not having worry about week-long arrangements for kiddos makes a huge difference, especially to early-career folks who are more likely to have young kids.
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Christian Odendahl @codendahl.bsky.social · 28/03/2025
Nobel Prizes by country and year. The dominance of Germany is striking every time. Before 1933, that is. And the utter dominance of America (and the UK) after 1945.
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Dan Diamond @ddiamond.bsky.social · 28/03/2025
See this chart for one stark example: NIH funding has dramatically slowed down. Grant awards are down *$3 billion* so far, compared to same time period last year I asked the White House to explain. “This is not a researcher entitlement program,” said an official, defending their new approach.
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Constance Bailey @constancebailey.bsky.social · 29/03/2025
Sounds like a grift
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Charlotte Clymer @charlotteclymer.bsky.social · 27/03/2025
Countries that have issued a travel advisory this year warning their citizens about visiting the United States: Canada Denmark Finland France Germany Ireland Netherlands New Zealand United Kingdom
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Eric Topol @erictopol.bsky.social · 27/03/2025
This doesn't look good, folks www.nature.com/articles/d41...
nature.com
75% of US scientists who answered Nature poll consider leaving
More than 1,600 readers answered our poll; many said they were looking for jobs in Europe and Canada.
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Dr. Kat Napaaqtuk❄️ @napaaqtuk.bsky.social · 26/03/2025
Imagine if those funds went to paying students, technicians, or postdocs to do more research. 🧪
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Colin Jackson @cjjackson.bsky.social · 26/03/2025
biorxiv.org/content/10.1... Here’s a paper that was many years in the making. The idea that the climate can affect the thermodynamic mechanism of binding due to the temperature dependence of the entropy term is interesting- we see gradual shift in binding mode along evo trajectory…
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Constance Bailey @constancebailey.bsky.social · 25/03/2025
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Amy Maxmen, PhD @amymaxmen.bsky.social · 19/03/2025
Studies terminated at NIH: -On reducing asthma from mold -On prenatal risks & screening -On statins influence on dementia -On the safety/risk of gender-affirming care -On how Covid vax outcomes & disparities -On improving HIV care -Training programs for the next generation of scientists
taggs.hhs.gov
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Constance Bailey @constancebailey.bsky.social · 25/03/2025
Feels like the ultimate goal in molecular construction, but is only relevant if it's to make something that will be used by others
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Constance Bailey @constancebailey.bsky.social · 25/03/2025
When done on something exciting and complicated in a clever fashion, however difficult, makes a beautiful paper
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Constance Bailey @constancebailey.bsky.social · 25/03/2025
Far easier to publish along the way steps that make such endeavors feasible rather than the actual application (e.g. characterising promoters on reporters or showing the capacity to make a strain with precursor flux vs. demonstrating stereoselective methodology)
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Constance Bailey @constancebailey.bsky.social · 25/03/2025
Is typically a long term project taking at least a PhD to do, depending on the complexity and not amenable to quick results within 6 months.
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Constance Bailey @constancebailey.bsky.social · 25/03/2025
Heterologous expression of complex BCGs has a lot of analogies to total synthesis. Easy to get "so what, why did you spend time doing this" if it's a target that is not exciting enough from a biological activity standpoint.
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Constance Bailey @constancebailey.bsky.social · 24/03/2025
Excited to speak at the Cell Free Systems conference this year. Even better, I can stay with my parents in my childhood home who live minutes away from Northwestern! www.aiche.org/sbe/conferen...
aiche.org
3rd Cell Free Systems Conference
The Cell Free Systems Conference will focus on understanding, harnessing and expanding the capabilities of biological systems without living intact cells.
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Constance Bailey @constancebailey.bsky.social · 24/03/2025
Perfect thank you--I figured as much, have been sending papers on how to purify as a plan B to my grad student. My grad student will be sad to hear this (more work for her!) but may that means it's time for us to focus on our Streptomyces lysate projects for the time being!
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Constance Bailey @constancebailey.bsky.social · 24/03/2025
No, we need E. coli tRNA, this is human tRNA, so I'm afraid not. Yeast tRNA is still available as well, oddly.
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Constance Bailey @constancebailey.bsky.social · 24/03/2025
Interesting! Honestly for promoting purely professional stuff like papers, positions, etc. I get the most relevant engagement from LinkedIn these days!
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Constance Bailey @constancebailey.bsky.social · 24/03/2025
Cell free people--anyone notice that E. coli tRNA is no longer being sold by Sigma: sigmaaldrich.com/AU/en/produc... Any advice for alternative suppliers?
sigmaaldrich.com
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Constance Bailey @constancebailey.bsky.social · 24/03/2025
I've been noticing that despite having a larger follower count here (probably due to starter packs) and being followed by many of the same people here as Twitter/X, I still have more engagement over there. What do we need to do to boost the algo here?
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Constance Bailey @constancebailey.bsky.social · 23/03/2025
Also: how will there be a training set if all we do is reorganize collected knowledge than create new experimental knowledge?
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Karen Attiah @karenattiah.bsky.social · 21/03/2025
So uh... how exactly is America going to host the World Cup next year with all these travel and immigration restrictions?
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Mark Cuban @mcuban.bsky.social · 22/03/2025
From 2010 to 2016 (latest data I have ), NIH research contributed to EVERY drug approved by the FDA
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Constance Bailey @constancebailey.bsky.social · 22/03/2025
Note that I am VERY happy to be in Australia and love our community, and happy to not be in the middle of the mess in the US right now. But what goes on in the US affects everywhere.
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Constance Bailey @constancebailey.bsky.social · 22/03/2025
"Sheehy said US funding accounted for more than $400m in 2024 alone – equivalent to around half the funding the federal government provided in research grants via the Australian Research Council." Oof
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Constance Bailey @constancebailey.bsky.social · 22/03/2025
The US historically has been the biggest source of these and now is not really a source we can rely upon.
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Constance Bailey @constancebailey.bsky.social · 22/03/2025
It was only a matter of time, I suppose. As ARC/NHMRC funding gets more and more inadequate, we have been encouraged to look for international collaborative schemes in addition to domestic ones. www.theguardian.com/australia-ne...
theguardian.com
Australian university researchers told ‘woke gender ideology’ among reasons behind Trump funding cuts
Researchers receive memo notifying ‘temporary’ funding pause prompting push for Australian government to pursue European partnerships
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Constance Bailey @constancebailey.bsky.social · 19/03/2025
Excited to share our review on applications of cell free expression towards natural products research, in collaboration with @nigelmouncey.bsky.social, Simon Moore, and Doug Mitchell! pubs.rsc.org/en/Content/A...
pubs.rsc.org
Cell-free synthetic biology for natural product biosynthesis and discovery
Natural products have applications as biopharmaceuticals, agrochemicals, and other high-value chemicals. However, there are challenges in isolating natural products from their native producers (e.g. b...
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Constance Bailey @constancebailey.bsky.social · 12/03/2025
My main gripe is the length of grants. If many grants are only for 2 years, it’s really challenging for project continuity.
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Constance Bailey @constancebailey.bsky.social · 11/03/2025
100%. I am so glad I moved.
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