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Daniela Danková

@danieladankova.bsky.social

60 followers 195 following 10 posts

@Astrazeneca Postdoc | Chemist | @ChristianAOlsen lab alumni @UCPH_health | In the lab 🧪- on the court 🏀 - outdoors 🏞

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Reposted by Daniela Danková

Alexander L. Nielsen @alexanderln.bsky.social · 16/02/2025

Our work on macrocyclic HDAC11 inhibitors is now out in JACS Au! pubs.acs.org/doi/10.1021/... #openaccess #chemsky

pubs.acs.org

Discovery of De Novo Macrocycle Inhibitors of Histone Deacetylase 11

Histone deacetylase (HDAC) enzymes are epigenetic regulators that affect diverse protein function by removing acyl groups from lysine side chains throughout the proteome. The most recently discovered ...

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Reposted by Daniela Danková

Carlos Moreno-Yruela @carlosmyruela.bsky.social · 04/02/2025

#SIRT7 is a histone deacetylase with highly specific activity on #chromatin substrates. We just published mechanism-based #cryoEM structures of #SIRT7 on nucleosomes to understand its activity 👇 www.nature.com/articles/s41... (1/8) #ChemBio #ChemSky

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Daniela Danková @danieladankova.bsky.social · 13/12/2024

Happy to share the latest preprint from my PhD studies on the discovery of de novo macrocyclic inhibitors of HDAC11. This was a great collaboration between @christianaolsen.bsky.social lab (@carlosmyruela.bsky.social, @tnhansen.bsky.social) and Christian Heinis lab (@alexanderln.bsky.social).

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