Reposted by Tobias N Hansen
Check out the final version of this paper. Now out in #JACS_Au @pubs.acs.org
pubs.acs.org/doi/10.1021/...
pubs.acs.org
Discovery of De Novo Macrocycle Inhibitors of Histone Deacetylase 11
Histone deacetylase (HDAC) enzymes are epigenetic regulators that affect diverse protein function by removing acyl groups from lysine side chains throughout the proteome. The most recently discovered ...
