A central hallmark of Parkinson′s disease (PD) is the spread of α-Synuclein (α-Syn) aggregates, which is thought to contribute to its progressive nature. To better understand the mechanism of cellular...

npj Parkinson's Disease - LRRK2 kinase mediates increased GCase activity in microglia in response to IFNγ-induced proinflammatory stimulation

The α-synuclein protein, encoded by SNCA gene, is a major constituent of pathological intracellular inclusions such as Lewy bodies found in the brains of patients with Parkinson’s disease and other sy...

Variants in the LRRK2 and GBA1 genes are among the most common risk factors associated with Parkinson's disease (PD). Both patients carrying PD-associated variants in GBA1, encoding lysosomal enzyme g...

α-Synuclein seed amplification assays are a promising diagnostic tool for synucleinopathies such as Parkinson disease and multiple system atrophy. Standardized conditions are required to ensure a high...

Human midbrain organoids (hMOs) show promise as a patient-derived model for the study of Parkinson's disease (PD). Yet, much remains unknown about how accurately hMOs recapitulate key features of PD i...

La plateforme de caractérisation des anticorps YCharOS s’attaque à la « crise de la reproductibilité » dans la recherche Le gouvernement du Québec par l’intermédiaire du CQDM vient d’octroyer une…