Central glucose-dependent insulinotropic polypeptide receptor (GIPR) signalling is required for the efficacy of GIP-based obesity therapeutics, yet how distinct subpopulations of GIPR neurons shape ap...

Glucagon-like peptide-1 receptor (GLP-1R) activation in the brain strongly reduces appetite, but most brain GLP-1Rs are not accessible for systemically administered GLP-1R agonists. Acute activation o...

Abstract. Glucagon-like peptide-1 (GLP-1) is produced within the central nervous system (CNS) by preproglucagon (PPG) neurons. This brain-derived GLP-1, ra

Explore the role of GLP-1 in regulating hunger and appetite, uncovering its complex mechanisms in the brain and gut.

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Neuron–glia interactions play a vital role in brain development, influencing processes like neuronal differentiation, synapse development, and myelination. In the mature brain, glial cells maintain h...