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Bastien Castagner🇨🇦

@castagner.bsky.social
787 followers 738 following 35 posts

Professor at McGill. Drug Discovery, C. difficile infection, microbiota, chemical biology, prebiotics, glycans, polyphenols, inositol phosphates. Running/biking CastagnerLab.com

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Reposted by Bastien Castagner🇨🇦
Cameron Thrash @jcamthrash.bsky.social · 26/08/2026
A roadmap to create FAIR collections of microbial strains www.nature.com/articles/s41... #jcampubs
nature.com
A roadmap to create FAIR collections of microbial strains - Nature Microbiology
Here the authors propose guidance on the process of establishing a state-of-the-art collection of microorganisms, including project planning, strain deposition and the naming of new taxa.
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Reposted by Bastien Castagner🇨🇦
Microbiome Virtual International Forum @microbiomevif.bsky.social · 17/07/2026
✨Season 6✨ starts w/ a special event! Seerave & #MVIF Symposium: Microbiome Modifiers and Cancer Immunotherapy Join researchers, clinicians & innovators as Seerave Foundation & #MVIF convene a global community around oncology-microbiome evidence to shape actionable recommendations!
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Bastien Castagner🇨🇦 @castagner.bsky.social · 03/07/2026
In this new paper by Seyed Ehsan Vasegh and colleagues, we show that inositol thiophosphates are substrate-mimicking competitive inhibitors of phytase enzymes (inositol phosphatases) from different kingdom. Published in @pubs.acs.org ACS Chem. Biol. pubs.acs.org/doi/10.1021/...
pubs.acs.org
Inositol Thiophosphates as Inhibitors of Mammalian, Plant, and Fungal Phytases
Inositol phosphates constitute a conserved family of signaling molecules that regulate a wide range of cellular processes such as energy metabolism, calcium release, and signal transduction. In mammal...
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Reposted by Bastien Castagner🇨🇦
Hutlab @hutlab.bsky.social · 02/03/2026
IMP ANNOUNCEMENT 🚨 Harvard Chan Microbiome in Public Health Center (co-directed by Wendy Garrett & Curtis) will host its annual symposium on May 18 @ Harvard T.H. Chan School @hsph.harvard.edu. The theme is 'Translating the Microbiome'. Poster abstracts are due April 1. Register : hsph.me/hcmph2026
hsph.me
HCMPH Symposium | Harvard Chan Microbiome in Public Health Center | Harvard T.H. Chan School of Public Health
We are delighted to welcome everyone to the eighth annual Harvard Chan Microbiome in Public Health Center (HCMPH) symposium. As microbial community science
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Reposted by Bastien Castagner🇨🇦
Karla Satchell @karlasatchell.bsky.social · 02/03/2026
Announcing the 4th Lakeside Conference on Protein Toxins and Effectors 2026 Registration/Abstract Submission is OPEN (#lakesidePTE)! Come join this premier event on the structure, biochemistry, and cell biology of Microbial Protein Toxins Oct 12-15, 2026. event.fourwaves.com/lakesidepte2...
Conference banner showing trees with leafs changing colors.
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Bastien Castagner🇨🇦 @castagner.bsky.social · 23/02/2026
Free registration is now open for the: Inositol Phosphates 2026, the more, the merrier – 6th edition, a virtual international meeting on inositol phosphates across organisms -March 25-27, 2026- Schedule and registration link on our website: castagnerlab.com/inositol-pho...
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Reposted by Bastien Castagner🇨🇦
Michael Zimmermann Lab @zimmermannlab.bsky.social · 09/02/2026
🚨 Do you work on microbial-mediated biotransformation of chemical compounds? 🧪 We would value your input to help us develop a standardized reporting framework for Xenobiotics–Microbiome interactions! 👉 Take the short survey (6–8 min): forms.gle/JNATejDrV2LR... ⬇️ ⬇️ ⬇️
forms.gle
MIX-MB (Minimum Information about Xenobiotics-Microbiome Biotransformation) - Community Consensus Survey
This survey aims to establish the Minimum Information about Xenobiotics-Microbiome Biotransformation (MIX-MB) reporting standards. As we move toward an era of AI-driven discovery, the structural and f...
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Reposted by Bastien Castagner🇨🇦
McGill Medicine and Health Sciences @healthsciences.mcgill.ca · 29/01/2026
National Day of Remembrance of the Quebec City Mosque Attack ~ On January 29, McGill will honour the memories of the victims with a special ceremony and lecture, Impacts of Islamophobia on Muslim Mental Health, by McGill psychiatry professor Salam El-Majzoub, MD. 🔗https://ow.ly/BzwB50XY29F
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Reposted by Bastien Castagner🇨🇦
Chris McCray @mccraywx.bsky.social · 05/12/2025
Rencontre concernant la piste cyclable sur Atateken, lundi prochain à 18h30 à la salle du conseil de Ville-Marie. Cette piste devrait servir de détour de la piste Berri durant environ 2 ans. Je vous invite à assister si vous avez des opinions sur cette piste!
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Bastien Castagner🇨🇦 @castagner.bsky.social · 26/11/2025
Just out in npj Biofilms & Microbiomes! Reilly Pidgeon and Arianna Giurleo complete another piece of the puzzle of polyphenol metabolism by the gut microbiome. Here they uncover a new 10-hydroxy urolithin dehydroxylase encoded by some Enterocloster spp. www.nature.com/articles/s41...
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Reposted by Bastien Castagner🇨🇦
Nature Microbiology @natmicrobiol.nature.com · 18/11/2025
#NewResearch A bile acid-bound structure of toxin TcdB revealed the mechanism of inhibition and guided the design of a synthetic bile acid that alleviated C. difficile infection in mice. #MicroSky 🦠💊 www.nature.com/articles/s41...
nature.com
Structure-guided design of a synthetic bile acid that inhibits Clostridioides difficile TcdB toxin - Nature Microbiology
A bile acid-bound structure of toxin TcdB revealed the mechanism of inhibition and guided the design of a synthetic bile acid that alleviated Clostridioides difficile infection in mice.
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Bastien Castagner🇨🇦 @castagner.bsky.social · 04/11/2025
Calling Inositol Phosphate enthusiasts! The free virtual international meeting on inositol phosphates across organisms - Inositol Phosphates 2026 - will take place on March 25-27, 2026. Currently accepting abstract for oral presentation until Dec. 7. castagnerlab.com/inositol-pho...
Flyer with text: Inositol Phosphates 2026, The more, the merrier - 6th edition
A virtual international meeting on inositol phosphates across organisms
 · March 25-27, 2026 ·
Deadline for oral presentation abstract submission: December 7.
https://castagnerlab.com/inositol-phosphates-2026/
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Bastien Castagner🇨🇦 @castagner.bsky.social · 04/11/2025
Continuons d'avancer! 🚲 Le REV Saint-Denis, une piste cyclable qui atteint des sommets www.lapresse.ca/dialogue/chr...
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Bastien Castagner🇨🇦 @castagner.bsky.social · 04/11/2025
This! Let's resist the politicization of science! 🇨🇦
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Reposted by Bastien Castagner🇨🇦
Keystone Symposia @keystonesymposia.bsky.social · 12/08/2025
Two conferences, one reg! Sign up for Microbiome Metabolism & Metabolites + get Human Microbiome FREE. Joint keynotes: Emily P. Balskus & Mohamed S. Abou Donia. keysym.us/KSMicroMetab26 @pieterdorrestein.bsky.social @mfgrp.bsky.social @inesthiele.bsky.social #KSMicroMetab26 #KSMicrobiome26
keysym.us
Microbiome Metabolism and Metabolites: Discovery and Function in Health and Disease | Keystone Symposia
Join us at the Keystone Symposia on Microbiome Metabolism and Metabolites: Discovery and Function in Health and Disease, January 2026, in Banff, with field leaders!
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Bastien Castagner🇨🇦 @castagner.bsky.social · 19/09/2025
We are hiring! Tenure track position in the area of Pluripotent Stem Cells in Regenerative Medicine in the Department of Pharmacology & Therapeutics at McGill University and the Research Institute of the McGill University Health Centre (RI-MUHC). mcgill.wd3.myworkdayjobs.com/en-US/McGill...
mcgill.wd3.myworkdayjobs.com
Assistant Professor (Tenure Track), Department of Pharmacology and Therapeutics, Pluripotent Stem Cells in Regenerative Medicine (L000066)
Please refer to the How to Apply for a Job (for External Candidates) job aid for instructions on how to apply. If you are an active McGill employee (ie: currently in an active contract or position at ...
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Reposted by Bastien Castagner🇨🇦
Nature Reviews Drug Discovery @natrevdrugdiscov.nature.com · 04/09/2025
The gut microbiome has a key role in shaping the immune response to cancer and influencing the efficacy of immunotherapy. Read about advances in targeting the microbiome in cancer treatment in this Review in the September issue www.nature.com/articles/s41... rdcu.be/eD8M5
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Bastien Castagner🇨🇦 @castagner.bsky.social · 07/08/2025
New preprint on polyphenol metabolism by gut bacteria! We show that released urolithin M6 is metabolized by regioselective dehydroxylases including the novel Uxd present in a subset of Enterocloster spp. Interestingly, Uxd induction is controlled by Ucd substrates. www.biorxiv.org/content/10.1...
Schemes showing Urolithins M6 released by Gordonibacter bacteria and taken up by Entercloser and metabolized into urolitin A by its two regioselective dehydroxylases Ucd and Uxd, that are close in the genome.
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Reposted by Bastien Castagner🇨🇦
RSC Chemical Biology @rscchembio.rsc.org · 20/05/2025
IP6 is cool, but IT6 is cooler 😎 A thiophosphate swap makes inositol hexakisphosphate more stable, more soluble, and stickier to bacterial virulence factors. Great news for structural bio & drug design! 📖 doi.org/10.1039/D4CB...
doi.org
Thiophosphate bioisosteres of inositol hexakisphosphate enhance binding affinity and residence time on bacterial virulence factors
Inositol phosphates are essential for mammalian cell signalling with critical roles in cellular processes. The fully phosphorylated inositol phosphate, myo-inositol hexakisphosphate (IP6), modulates numerous eukaryotic proteins and bacterial virulence factors. It has been suggested that the high charge density of I
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Reposted by Bastien Castagner🇨🇦
Dare Obasanjo @carnage4life.bsky.social · 01/07/2025
A new paper in The Lancet, one of the world’s foremost peer reviewed medical journals, estimates that USAID prevented 91 million deaths across 133 countries over 20 years. The paper estimates that Elon Musk’s DOGE funding cuts to USAID will lead to 14 million deaths by 2030 (4.5 million children).
thelancet.com
Evaluating the impact of two decades of USAID interventions and projecting the effects of defunding on mortality up to 2030: a retrospective impact evaluation and forecasting analysis
USAID funding has significantly contributed to the reduction in adult and child mortality across low-income and middle-income countries over the past two decades. Our estimates show that, unless the a...
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Bastien Castagner🇨🇦 @castagner.bsky.social · 13/06/2025
@mcgill.ca is recruiting an internationally recognized scientist in Human Immunology for the prestigious Canada Excellence Research Chair. Montreal offers a vibrant scientific ecosystem in a fantastic city. www.nature.com/naturecareer...
nature.com
Canada Excellence Research Chair (CERC) in Human Immunology - Montréal, Quebec (CA) job with McGill University Faculty of Medicine and Health Sciences | 12840439
Canada Excellence Research Chair (CERC) in Human Immunology (Faculty of Medicine and Health Sciences, McGill University)
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Bastien Castagner🇨🇦 @castagner.bsky.social · 03/06/2025
Our review on gut microbiome manipulation for cancer immunotherapy is out. Thanks to Arielle Elkrief, Reilly Pidgeon, Saman Maleki Vareki, Meriem Messaoudene, and @bertrandrouty.bsky.social
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Bastien Castagner🇨🇦 @castagner.bsky.social · 21/05/2025
Such a disappointing and infuriating message from @McGill.ca President. McGill is “neutral” in geopolitical crisis and cannot comment, YET they will invest in military weapons and do business partnership with the UAE Army for instance.
Email portion that reads: Dear members of the McGill community,
 
Many of us are watching the escalation of human suffering in Gaza with alarm. While thousands of kilometres away, many members of the McGill community are touched at a human level by the scale and impact of the crisis unfolding, which threatens to intensify over the coming days.
 
To reiterate my past messages, McGill, as a university, must remain mindful of its academic mission and refrain from commenting or taking a position on a geopolitical crisis. That said, we will always express compassion for and extend care to our community members affected by international emergencies.
 
If you need support, please do not hesitate to reach out. Resources are set out below.
 
Sincerely,
 
Deep Saini
President and Vice Chancellor
McGill University
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Reposted by Bastien Castagner🇨🇦
Henning Jessen @jessenlab.bsky.social · 18/04/2025
An alternative strategy to access inositol derivatives by stereoselective dephosphorylation. Happy to share the work by Markus Haener together with @gabrielschaaf.bsky.social and many others. chemrxiv.org/engage/chemr...
chemrxiv.org
Stereoselective chemoenzymatic phytate transformations provide access to diverse inositol phosphate derivatives
Phosphorylated myo-inositols (InsPs) are essential cytoplasmic signaling molecules, while their lipidated analogs (PtdInsPs) play a crucial role in membrane signaling. Stereoselective synthesis of the...
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Reposted by Bastien Castagner🇨🇦
Brian Owens @scibri.com · 09/04/2025
Echoing Trump, Pierre Poilievre's election pitch includes pledge to end "woke influence" in university research. My story for @science.org 🧪 #cdnpoli www.science.org/content/arti...
science.org
In Canadian election, top Conservative candidate vows to end ’woke ideology’ in science funding
Pierre Poilievre’s Conservative Party is trying to topple Liberal government in 28 April election
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Reposted by Bastien Castagner🇨🇦
Timothy Caulfield @caulfieldtim.bsky.social · 08/04/2025
Evil. "Without continued PEPFAR programmes, models predict that by 2030, an additional 1 million children will become infected with HIV, 0·5 million additional children will die of AIDS, & 2·8 million children will additionally become orphaned by AIDS." Study: www.thelancet.com/journals/lan...
thelancet.com
Protecting Africa's children from extreme risk: a runway of sustainability for PEPFAR programmes
PEPFAR (President's Emergency Plan for AIDS Relief), a landmark US foreign health policy, is recognised for saving 26 million lives from HIV. PEPFAR investments have also had life-saving impacts for c...
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Reposted by Bastien Castagner🇨🇦
Sylvain Baillet @sylvainbaillet.bsky.social · 02/04/2025
🚨We're hiring another tenure-track at McGill University: focus on brain-body science! 👇 mcgill.wd3.myworkdayjobs.com/en-US/mcgill...
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Bastien Castagner🇨🇦 @castagner.bsky.social · 02/04/2025
Molecular dynamic simulations led to a better understanding of the C. difficile toxin B (TcdB) allosteric transition induced by inositol hexakisphosphate (IP6). Useful info for drug discovery. Great work by Lauren Finn, Rebecca Cummer, and @bettinagkeller.bsky.social! www.pnas.org/doi/10.1073/...
Crystal structure of the C. difficile toxin B (TcdB) showing the beta-flap in its lowered and raised conformation. The inositol hexakisphosphate (IP6) is shown in the holo-raised conformation.
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Reposted by Bastien Castagner🇨🇦
D2R | DNA to RNA @d2rmcgill.bsky.social · 31/03/2025
📅 April 24 | Next-Generation #RNA Vaccines & Therapies This event is organized by McGill's Pharmacology and Therapeutics and will feature lecture speaker Dr. @annablakney.bsky.social from UBC (also a D2R-funded researcher!). More info: mcgill.ca/pharma/semin...
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Bastien Castagner🇨🇦 @castagner.bsky.social · 30/03/2025
Important for us Canadians. We cannot let that happen.
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Bastien Castagner🇨🇦 @castagner.bsky.social · 27/03/2025
The Inositol Phosphates international meeting will take place on March 25-27, 2026 (virtually)! Please mark your calendars and sign up below to receive email updates about registration and abstract submission! Organized with Inmaculada Couso, Martina Ried-Lasi. castagnerlab.com/inositol-pho...
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Bastien Castagner🇨🇦 @castagner.bsky.social · 24/03/2025
We are recruiting! The McGill University Department of Pharmacology and Therapeutics in the Faculty of Medicine and Health Sciences invites applications for a full-time tenure track Assistant or Associate Professor position in the area of toxicology. mcgill.wd3.myworkdayjobs.com/en-US/McGill...
mcgill.wd3.myworkdayjobs.com
Assistant/Associate Professor (Tenure Track), Department of Pharmacology and Therapeutics, Toxicology (L000054)
Please refer to the How to Apply for a Job (for External Candidates) job aid for instructions on how to apply. If you are an active McGill employee (ie: currently in an active contract or position at ...
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Bastien Castagner🇨🇦 @castagner.bsky.social · 20/03/2025
In this new publication, Rebecca Cummer shows that inositol thiophosphate is a useful bioisostere of inositol hexakisphosphate (IP6) that binds more strongly to different bacterial virulence factors. In collaboration with Dr. Nagar and Dr. @bettinagkeller.bsky.social. pubs.rsc.org/en/Content/A...
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Bastien Castagner🇨🇦 @castagner.bsky.social · 19/03/2025
Indeed concerning. I will not be attending (or sending a student to) any conferences in the US because of the current trade war with Canada, but this is something else! Here is the article in French. www.lemonde.fr/internationa...
lemonde.fr
Etats-Unis : un chercheur français refoulé pour avoir exprimé « une opinion personnelle sur la politique menée par l’administration Trump »
Le ministre de la recherche français a dit sa « préoccupation », mercredi, après cette décision des autorités américaines. Le chercheur du CNRS aurait subi un contrôle aléatoire à son arrivée, avant q...
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Bastien Castagner🇨🇦 @castagner.bsky.social · 18/03/2025
We are good colleagues (if I may say do myself), we still believe in diversity, our students are amazing and the quality of life in Montreal is great. Come talk. To us!
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Bastien Castagner🇨🇦 @castagner.bsky.social · 05/03/2025
I signed this letter of Canadians in support of science and in solidarity with our American friends and colleagues 🇨🇦🤝🇺🇲. And to my fellow Canadian, while our situation is better, anti-science is creeping up in our politics as well. So we need to work better to show the cool stuff we do!💊🧪🧫🧬(and vote)
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Bastien Castagner🇨🇦 @castagner.bsky.social · 24/01/2025
New paper finally out! Reilly Pidgeon shows how the biologically active end metabolite urolithin A is produced by the microbiome from its dietary precursor derived from polyphenols. Great work featuring Sacha Mitchell and collaborator Dr. Corinne Maurice. www.nature.com/articles/s41...
Scheme depicting ellagic acid being converted to urolithin C which in turn is metabolized by Enterocloster species in the gut microbiome  into urolithin A, which can be absorbed. Includes a figure that shows proteomics and transcriptomics data both demonstrating the inducible ucdCFO metabolic gene cluster.
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Reposted by Bastien Castagner🇨🇦
Madhu Pai, MD, PhD @madhupai.bsky.social · 24/01/2025
For 20 years, I have served WHO in various advisory groups Because @who.int is made up of nations and, thus, all of us. Today, I showed my solidarity by contributing to this 1 Dollar, 1 World campaign to raise 1B in these uncertain times Join me! whofoundation.donorsupport.co/page/FUNEKRB...
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Bastien Castagner🇨🇦 @castagner.bsky.social · 06/01/2025
New paper! We used metatranscriptomics of a human microbiome sample after a short incubation with prebiotic glycans to identify consuming bacteria. Great work by Catherine Prattico and our cool collaborators. Featuring fructans, Blautia spp., and SACCHARIS v2. journals.asm.org/doi/10.1128/...
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Reposted by Bastien Castagner🇨🇦
Ruairi Robertson @ruairirobertson.bsky.social · 20/11/2024
🦠🔬🚨 I have created a starter pack for those involved in research related to human microbiomes (there are other excellent microbiome packs by @claesengroup.bsky.social but this differentiates human from environmental/plant microbiomes). Let me know if you would like to be added! go.bsky.app/3eeA7BP
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Bastien Castagner🇨🇦 @castagner.bsky.social · 20/11/2024
In 2 recent(ish) contributions published in Nat. Commun. and ACS Chem. Biol., we use FACS to sort gut bacteria that interact with fluorescent glycans in human microbiota samples. www.nature.com/articles/s41... pubs.acs.org/doi/10.1021/...
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Bastien Castagner🇨🇦 @castagner.bsky.social · 18/11/2024
Join the McGill Interdisciplinary Initiative in Infection and Immunity (MI4) for their Annual Symposium on Dec. 4. The theme "Microbiome: Decoding the Invisible World," promises an engaging lineup, including a keynote by Prof. Yasmine Belkaid, President of Institut Pasteur. www.mcgill.ca/mi4/events
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Bastien Castagner🇨🇦 @castagner.bsky.social · 15/11/2024
Join us for a World AMR Awareness Week (WAAW) special Seminar (hybrid) by Dr. Mark Miller on Nov. 21st organized by the McGill AMR Centre. Registration using the QR code or at www.mcgill.ca/amrcentre
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