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Casey Meili

@caseymeili.bsky.social
1.4K followers 1.1K following 39 posts

I infect mice with a brain virus and blame the gut for what happens next. PhD candidate studying how microbes, diet, and other gut disruptions shape seizures and neuroinflammation 🧠🦠 msha.ke/caseymeili

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Casey Meili @caseymeili.bsky.social · 30/09/2026
Negative results move science forward. Excited to contribute to our understanding of when the ketogenic diet is, and isn’t, effective for epilepsy. Huge thanks to my co-authors and my mentor, @biadepaula-silva.bsky.social, for making this work possible!
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Casey Meili @caseymeili.bsky.social · 30/09/2026
Our findings suggest that the antiseizure effects of KD are highly context-dependent. Mechanisms that are protective in other epilepsy models may not overcome the significant neuroinflammation driving infection-associated seizures.
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Casey Meili @caseymeili.bsky.social · 30/09/2026
Additionally, KD dramatically reshaped the gut microbiota, including enrichment of taxa such as Akkermansia, but these microbiota changes alone were not sufficient to protect against inflammation-driven seizures.
Large stacked bar chart divided by control and KD and divided by day -1 (pre infection) and 7 days post infection. The KD communities look noticeably different from control. The bottom is 3 different box plots, each with the same group. Each is a different alpha diversity metric, first is “species observed” labeled richness, the second is pielou’s evenness labeled evenness and the third is Shannon index labeled community diversity. All three graphs show a significant reduction in diversity in the KD fed group relative to the time matched control box.
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Casey Meili @caseymeili.bsky.social · 30/09/2026
KD only induced limited neuroimmune changes, including an increase in CD4+ T cells and reduction of NK cells. We found no alterations in total immune cell infiltration, myeloid cell abundance, or macrophage/microglia phenotype.
Two graphs. The left shows NK1.1+ cells and the right shows CD4+ T cells both as a percentage of total lymphocytes. In the left graph KD is significantly decreased from the control and in the right KD is significantly increased relative to control
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Casey Meili @caseymeili.bsky.social · 30/09/2026
Using the Theiler’s murine encephalomyelitis virus (TMEV) model, we found that despite achieving sustained ketosis, KD did not reduce seizure incidence or severity.
Two graphs. The left graph is labeled “seizure incidence” and shows the control group with 65% of mice having seizures and the KD group with 57% of mice having seizures. The graph on the right is seizure score cumulatively from day 3-7 post infection. There is no difference between the control and KD lines.
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Casey Meili @caseymeili.bsky.social · 30/09/2026
🎉 Excited to share my latest work out now in @epilepsiajournal.bsky.social! doi.org/10.1002/epi.... We asked whether the ketogenic diet (KD), a well-established therapy for drug-resistant epilepsy, is also effective against infection-driven seizures. 🧵⬇️
doi.org
Ketogenic diet fails to mitigate seizures and neuroinflammatory responses in a mouse model of virus‐induced epilepsy
Objective The ketogenic diet (KD) is a high-fat, low-carbohydrate intervention widely used to treat drug-resistant epilepsy, thought to reduce seizures through a combination of metabolic, neuronal, ...
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Karen S Wilcox, PhD (she/her) @karenswilcoxphd.bsky.social · 12/11/2025
After 10 years, I am stepping down as chair of our department and we have an active search going on! Utah is a phenomenal place to live and work and it's been the honor of a lifetime chairing the department founded by Lou Goodman. #MedSky #Neuroskyence Repost! jobs.chronicle.com/job/37914733...
jobs.chronicle.com
Chair of Pharmacology and Toxicology - Salt Lake City, Utah job with The University of Utah | 37914733
The University of Utah seeks a Chair of Pharmacology and Toxicology
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Casey Meili @caseymeili.bsky.social · 14/08/2025
The last paper from my masters has been accepted! (I graduated in 2023)
Silhouette of a man facing a sunset with his arms above his head. His arms have shackles which are breaking above his head.
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Casey Meili @caseymeili.bsky.social · 10/07/2025
They work by drawing water into the system through a semipermeable membrane. This creates pressure inside the device, which pushes the drug out through a small opening at a controlled, steady rate. It allows consistent drug delivery over time, independent of factors like pH or movement in the body.
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Casey Meili @caseymeili.bsky.social · 10/07/2025
Explained an osmotic drug pump to an undergrad today by comparing it to a CoronaRita
CoronaRita (Corona upside down in a margarita)
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Casey Meili @caseymeili.bsky.social · 20/06/2025
Aww thank you Bia! Couldn’t have done it without you 😊
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Ana Beatriz DePaula-Silva @biadepaula-silva.bsky.social · 20/06/2025
Congratulations to my first PhD student @caseymeili.bsky.social for passing her qualifying exam! She is officially a PhD candidate! So proud of you!
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Kai Kupferschmidt @kakape.bsky.social · 07/03/2025
“Thinking about the event in the U.S. capital started about a month ago, when five scientists, nearly all of them graduate and Ph.D. students, bonded on Bluesky over their concerns about the impact of Trump’s executive orders on science.” 🧪
science.org
Thousands gather across U.S. in Stand Up for Science events
Scientists rally across the country in response to layoffs and funding cuts ordered by the Trump administration
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Casey Meili @caseymeili.bsky.social · 07/03/2025
On a more personal note, my contribution to this work is something I am particularly proud of when I look back on the first year of my PhD. Here’s to lots more exciting science ahead 🥳 (And of course, feel free to contact me for the full text)
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Casey Meili @caseymeili.bsky.social · 07/03/2025
This thread can’t possibly summarize all of the amazing science that went into this paper (and all of the awesome scientists who made it possible). I highly recommend giving it a read if you have a chance!
media.tenor.com
a baby is reading a book with his eyes closed while sitting at a table .
ALT: a baby is reading a book with his eyes closed while sitting at a table .
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Casey Meili @caseymeili.bsky.social · 07/03/2025
Overall, this study emphasizes the significance of microbial diversity in early life and its potential to influence metabolic diseases like diabetes.
Graphical abstract showing that specific microbes promote mouse beta cell expansion during a critical postnatal period before weaning (days 10 to 20). Colonization by the fungal commensal C. dubliniensis stimulates b cell mass through a macrophage-dependent mechanism. This effect appears to be activated by C. dubliniensis’ distinctive cell wall structure, which has reduced levels of both mannan and chitin. These early-life processes result in long-term metabolic health.
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Casey Meili @caseymeili.bsky.social · 07/03/2025
Interestingly, C. dub requires macrophages to increase beta cell mass. The specific composition of the fungal cell wall (specifically differences in mannan and chitin) may play a role in this process.
Two graphs, the first showing macrophages per islet across SPF, GF and mono associated E. coli, E. galinarum, L. reuteri, and C. dublinensis mice. Significantly more macrophages per islet in C. dub colonized mice. Graph two shows the ratio beta cell area between PBS and clodronate liposomes for both C. dub and E. gal mono associated mice. There is a significant difference in beta cell area between PBS and clodronate in C. dub but not E. gal
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Casey Meili @caseymeili.bsky.social · 07/03/2025
The microbiota also plays an important role in seeding islet-resident macrophages. In early life, macrophages promote beta cell mass expansion. Depleting macrophages in mice reduced insulin-producing tissue, indicating their role in beta cell expansion.
Representative islets from SPF and GF pups, aged P15. F4/80 or macrophages in white. Islet boundary denoted by white dashed line. Scale bar: 50 mm. There are many more macrophages in the SPF islet. Number of macrophages per islet in SPF (gray) and GF (white) animals at P10, P15, and P20.
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Casey Meili @caseymeili.bsky.social · 07/03/2025
Multiple microbes were found to play a role in this process including Candida dubliniensis (C. dub) but not closely related C. albicans. Colonization of the pup with C. dub also coincided with the critical window of beta cell expansion in early life.
Two graphs, the first showing beta cell mass in SPF, germ free mice and mice mono associated with E. coli, E. galinarum, L. reuteri, C. dublinensis, and C. albicans. The second graph shows C. dublinensis colonization (CFU/g) across the postnatal period.  There is no colonization days 0-10 with a significant increase at postnatal days 15 and 20.
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Casey Meili @caseymeili.bsky.social · 07/03/2025
Germ free mouse pups had reduced beta cell mass compared to mice with a normal microbiota indicating that the microbiota plays an important role in beta cell proliferation.
Two graphs, one showing that SPF mice have significantly greater beta cell mass than germ free mice and a second graph showing that there is no significant difference in pancreas mass. Histology showing difference in insulin between germ free and SPF pancreas.
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Casey Meili @caseymeili.bsky.social · 07/03/2025
In this work led by Jennifer Hill, we discovered how exposure to specific bacterial and fungal species during early life can influence pancreatic development and subsequent metabolic disease.
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Casey Meili @caseymeili.bsky.social · 07/03/2025
PAPER ALERT‼️ “Neonatal fungi promote lifelong metabolic health through macrophage dependent beta cell development” is out now in @science.org science.org/doi/10.1126/... A short 🧵 below
science.org
Neonatal fungi promote lifelong metabolic health through macrophage-dependent β cell development
Loss of early-life microbial diversity is correlated with diabetes, yet mechanisms by which microbes influence disease remain elusive. We report a critical neonatal window in mice when microbiota disr...
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Jeremy Koster @jeremykoster.bsky.social · 19/02/2025
Upon learning that yesterday would be my last day as a program officer at the National Science Foundation, I shared this parting message with my colleagues. The next few months will be frenetic and stressful for them. Here are some things that you can do to help them with the mission ahead. (1)
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Neil Lewis, Jr. @neillewisjr.bsky.social · 08/02/2025
8/8. So, if you’re feeling down about these attacks, I understand—I feel that way too. But just remember that they’re not attacking because your work doesn’t matter; they’re attacking *precisely* because it does. So, get some rest, connect with your people, and keep doing it.
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Elaine Hsiao @pipethero.bsky.social · 29/01/2025
Delighted to highlight new work by Kelly Jameson and colleagues showing that select microbial metabolites in the small intestinal lumen regulate vagal activity www.cell.com/iscience/ful...
cell.com
Select microbial metabolites in the small intestinal lumen regulates vagal activity via receptor-mediated signaling
Neuroscience; Microbiome
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Elisabeth Bik @elisabethbik.bsky.social · 03/02/2025
I am appalled by the ASM's decision to remove DEI content from their website. Here is my email to the American Society for Microbiology, @ASM.org asking them to put everything back as it was. If you are an ASM member, please consider writing them.
Subject: Appalled by the decision to remove DEI content on the ASM website

Dear ASM Leadership,

For over 20 years, I have been a proud member of the ASM, a professional society that not only publishes outstanding microbiology research but also supports diversity, equity, and inclusion within our field.

I am deeply disappointed and angered by ASM’s recent decision to remove online content that highlighted and celebrated non-white, female, and LGBTQ+ scientists. Rather than unquestioningly complying with vague governmental directives to halt and delete inclusion efforts, ASM should have taken a principled stand and kept this content accessible. 

Since ASM is not a federal agency and derives most of its funding from publishing and membership fees, this decision to remove content that so many of us support is both disheartening and perplexing.

I have read ASM’s statement following the recent STAT article, which claims that no content was deleted but is instead "under review." I must ask: under review for what purpose? Will the language be altered? Will key aspects be removed?

I urge ASM to demonstrate integrity and restore the content in its original form.

As BlueSky user Len Kurland worded it nicely, this is the perfect time for Microbial Resistance.


 
Kind regards,

Elisabeth Bik
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Casey Meili @caseymeili.bsky.social · 03/01/2025
“Idk, I just think the vibes are bad” -me to myself after rereading a grant I wrote
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Casey Meili @caseymeili.bsky.social · 06/12/2024
I’ll also be around for the rest of the conference if you can’t make it to my poster(s) but still want to chat!
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Casey Meili @caseymeili.bsky.social · 06/12/2024
Sunday I’ll be presenting on how Pioglitazone (a PPAR-y agonist used for treating type 2 diabetes) can modulate seizure development and immune cell infiltration/activation in the CNS in a viral-induced model (some surprising results here!) Sunday Dec 8, 12:00-2:00, poster 532
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Casey Meili @caseymeili.bsky.social · 06/12/2024
Saturday I’ll be talking about how the gut microbiota, diet, and derived metabolites influence seizure incidence and severity as well as immune response in a viral-induced seizure model. Saturday Dec 7, 12:00-2:00 pm, poster 084
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Casey Meili @caseymeili.bsky.social · 06/12/2024
On the way to #AES2024! I’ll be presenting posters on Saturday and Sunday. Stop by if you want to chat viral-induced epilepsy, neuroinflammation, or the microbiota 🦠🧠🐭 (Details on the posters below)
Graphic for the annual AES meeting reading “I am attending #AES2024 in Los Angeles”
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Casey Meili @caseymeili.bsky.social · 03/12/2024
Oh…thanks for keeping track of that
The Duolingo owl staring menacingly with the text “you made 672 mistakes this year”
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Casey Meili @caseymeili.bsky.social · 22/11/2024
I got a real request to peer review a paper for a real journal today???????? I am AFRAID.
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Ruairi Robertson @ruairirobertson.bsky.social · 20/11/2024
🦠🔬🚨 I have created a starter pack for those involved in research related to human microbiomes (there are other excellent microbiome packs by @claesengroup.bsky.social but this differentiates human from environmental/plant microbiomes). Let me know if you would like to be added! go.bsky.app/3eeA7BP
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Casey Meili @caseymeili.bsky.social · 21/11/2024
I would love to be added!
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Dani Beck, PhD @danibeck.bsky.social · 14/11/2024
"I'm going to finish this manuscript before Christmas!"
a girl looking into a mirror and seeing a reflection of herself as a clown
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Celtic Karla @celtickarla.bsky.social · 13/11/2024
Applications for Rising Stars in Neuroscience Symposium are due Dec 15! We are looking for exceptional grad students to Present your research, sharpen your science communication skills, and connect with peers and faculty. medicine.utah.edu/neurobiology... #STEMsymposium #neuroskyence #womeninSTEM 🧪
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Maria Viola @mariafviola.bsky.social · 13/11/2024
As my blatant tour of self-promotion continues.. macrophages are so much more than just cells that eat things! Yet, even the eating can be very cool. Here, we showed that macrophages in gut shape the nervous system, and this makes 💩 happen correctly in adulthood: www.nature.com/articles/s41...
nature.com
Dedicated macrophages organize and maintain the enteric nervous system - Nature
Resident macrophages of the muscularis externa refine the enteric nervous system (ENS) early in life by pruning synapses and phagocytosing enteric neurons, and later switch to a neuro-supportive funct...
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Casey Meili @caseymeili.bsky.social · 10/11/2024
I’m especially interested in how the gut microbiota, diet, and derived metabolites can influence neuroinflammation and disease onset/severity. Anyway - I’m so happy to see everyone and look forward to connecting ☺️
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Casey Meili @caseymeili.bsky.social · 10/11/2024
I’m so excited by the surge of scientists making their way over here! I’m Casey and I’m currently a second year PhD student 👋 I am studying neuroinflammation induced by viral infection of the CNS, particularly in the context of epilepsy 🧠
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Casey Meili @caseymeili.bsky.social · 25/10/2024
Emails from undergrads 💕
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Casey Meili @caseymeili.bsky.social · 09/02/2024
PAPER ALERT‼️ In our new study we characterized the anaerobic gut fungal communities of 10 marsupial species, evaluated the role of stochastic and deterministic factors in shaping AGF communities, and identified several commonalities with placental herbivores 🦘🐨 journals.asm.org/doi/10.1128/...
journals.asm.org
Anaerobic gut fungal communities in marsupial hosts | mBio
The AGF are integral part of the microbiome of herbivores. They play a crucial role in breaking down plant biomass in hindgut and foregut fermenters. The majority of research has been conducted on the...
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Casey Meili @caseymeili.bsky.social · 12/01/2024
You guys, look what finally showed up 😍
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Casey Meili @caseymeili.bsky.social · 20/12/2023
Honestly, listening to my mom explain my research to people at holiday parties is a master class in sci comm
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Casey Meili @caseymeili.bsky.social · 22/09/2023
Obviously it does. Welcome 😎
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Casey Meili @caseymeili.bsky.social · 21/09/2023
Oh how I would love to appropriately use the word florescence for once.
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Casey Meili @caseymeili.bsky.social · 21/09/2023
That’s a helpful way to think about it! Appreciate the tip!
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Casey Meili @caseymeili.bsky.social · 21/09/2023
I swear one of these days I will learn how to spell fluorescent 😅 (This post was brought to you by spell check).
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Alisa Bokulich @alisabokulich.bsky.social · 29/08/2023
A Bluesky quick primer 🧵 for recent arrivals: 1. check default settings -- they set to min threshold likes before see in feed-- can change to show all.
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Justin English @justingenglish.bsky.social · 05/09/2023
Excited for our upcoming PostDoc Rising Stars event this month!
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