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Anne-Ruxandra Carvunis

@carvunis.bsky.social
3K followers 2.4K following 59 posts

Associate Prof. University of Pittsburgh. Computational and Systems Biology. Mechanisms of Evolutionary Innovation. Yeast. www.carvunis.com.

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Reposted by Anne-Ruxandra Carvunis
Paper Skygest Team @paper-feed.bsky.social · 19/08/2025
**Please repost** If you're enjoying Paper Skygest -- our personalized feed of academic content on Bluesky -- we'd appreciate you reposting this! We’ve found that the most effective way for us to reach new users and communities is through users sharing it with their network
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Lucia Peixoto @sciencenlucia.bsky.social · 13/12/2025
It is Friday. Time for a new edition of #Autism: the #evidence. After spending some time talking about the consensus on what is behind the increase in #prevalence, and what does NOT cause autism, this week I am going to talk about what does, starting with #genetics
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Lucia Peixoto @sciencenlucia.bsky.social · 22/11/2025
It's Friday. This means it is time for a new post on #Autism : The Evidence. If you missed last week, I discussed what is TRULY behind the rise in prevalence. Today I am going to talk about what it is not: #VACCINES . They are SAFE and EFFECTIVE, but where did this idea come from?
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Lucia Peixoto @sciencenlucia.bsky.social · 15/11/2025
Today I am starting a weekly post titled "Autism: The Evidence". I hope it helps someone fight the colossal wave of misinformation that is drowning us. Part 1: I heard Autism prevalence has gone up. Is that true? If so why?
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Hassan uz Zaman @hassanzaman.bsky.social · 26/09/2025
After testing virtually all reasonable permutations of sample prep, spectra acquisition, database selection, data processing... This team (convincingly, I think) demonstrates that ~85% of the small, *annotated* bacterial proteins are undetectable by mass spec—much less non-annotated ones. (1/4) 🧵
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Jeremy Berg @jeremymberg.bsky.social · 18/06/2025
The findings at the recent trial and today's Columbia chaos is pushing me to the edge. I just sent the following email...
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Jason Moore @moorejh.bsky.social · 14/06/2025
I heard this morning that my informatics colleague Dr. Atul Butte passed after a battle with cancer. He was a giant in the field & inspired many of us over his distinguished career. He was a passionate champion of the power of big data & his impact on our field is immeasurable. RIP Atul & thanks.
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Carl T. Bergstrom @carlbergstrom.com · 07/06/2025
Very smart, high ROI initiative from the Spencer Foundation. Providing bridge funding for canceled NSF grants: 1) directs funds to projects already screened by a top-noch review process. 2) avoids imposing proposal prep costs on researchers. 3) ameliorates the disruption from GOP sabotage.
spencer.org
Rapid Response Bridge Funding Program
In the face of recent abrupt shifts in federal funding for education research, including large-scale terminations of National Science Foundation (NSF) research grant awards, we have developed a rap...
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Jeremy Berg @jeremymberg.bsky.social · 28/05/2025
Interview with a Harvard graduate student from Harvard about some of the consequences of the administration's current policies.
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Jeremy Berg @jeremymberg.bsky.social · 23/05/2025
Senator Durbin noted that some (I believe Republican Senators) had indicated the US had been doing more than its share of biomedical research and it was time for other countries take a turn. I felt I had to interrupt to respond...
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Michael Baym @baym.lol · 24/05/2025
I appreciate the offers from other scientists to help Harvard (students, labs, etc) through this attack, but what would be most helpful is for you to use your position to contact your elected representatives and make it clear this fight isn't just Harvard, it will affect you, and their districts too
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Teresa O'Meara @teresaomeara.bsky.social · 16/05/2025
I'm so excited to share a new preprint on exploring sequence, structure, and function relationships and how we can use evolutionary information to help us design new proteins that work in the native context of a cell www.biorxiv.org/content/10.1...
biorxiv.org
Deep homology and design of proteasome chaperone proteins in Candida auris
A central tenet of biology is that protein structure mediates the sequence-function relationship. Recently, there has been excitement about the promise of advances in protein structure modeling to gen...
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Dan Garisto @dangaristo.bsky.social · 07/05/2025
An NSF PO on its upcoming 75th anniversary: "In nature, systems evolve towards minimum of energy, following the laws of physics. In the US today things evolve to a location of maximum pain, violating the laws of the land." www.linkedin.com/posts/tomasz...
Post from PO about NSF
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Jeremy Berg @jeremymberg.bsky.social · 06/05/2025
As a follow-up to the Kaiser interview, here is my exchange with Dr. Bhattacharya starting Sunday evening... 1/n
A letter from Jeremy Berg to NIH Director Jayanta Bhattacharya about the need to award grants promptly.
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Gen Wojcik @genandgenes.bsky.social · 24/04/2025
I wrote about how we must stand and fight against the threat of eugenics. Fueled by white nationalism and scientific racism, these beliefs are factually wrong and ethically abhorrent. This fight includes supporting efforts to diversify our workforce & science. To stop now would be a deep betrayal.
nature.com
Eugenics is on the rise again: human geneticists must take a stand
Scientists must push back against the threat of rising white nationalism and the dangerous and pseudoscientific ideas of eugenics.
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Erna Magnúsdóttir @e-rna.bsky.social · 22/04/2025
Join our lab to study transcriptional regulation in mouse germ cells and embryonic stem cells at @haskoliislands.bsky.social in beautiful Reykjavík! Apply here: tinyurl.com/34y6jcrd #epigenetics #TranscriptionFactors #transcriptomics #stemCells #pluripotency
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Jeremy Berg @jeremymberg.bsky.social · 22/04/2025
ATTENTION I am hearing from several sources that "NIH" sent out termination notices for most or all "diversity" awards yesterday to coincide with the new Notice. If you were affected by this and are willing to share, please DM me or reach me on Signal (jeremymberg.78) 1/2
media.tenor.com
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Lucia Peixoto @sciencenlucia.bsky.social · 21/04/2025
April is #Autism Awareness Month. This is a month to accept, understand and love those in the Autism Spectrum. Above all accepting that someone is different and respecting their differences is the most important thing we can do. Here are some facts to help understand (a thread):
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Jeremy Berg @jeremymberg.bsky.social · 18/04/2025
Another moment of WTF... The evolution of the www.covid.gov site... Warning: May be jarring! 1/4
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Kevin Hall @kevinh-phd.bsky.social · 16/04/2025
After 21 years at my dream job, I’m very sad to announce my early retirement from the National Institutes of Health. My life’s work has been to scientifically study how our food environment affects what we eat, and how what we eat affects our physiology.
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c0nc0rdance @c0nc0rdance.bsky.social · 11/04/2025
All snails have tentacles. Some have 1 pair, other 2 pair. In some (but not all) snails, the eyes are placed at the end of one of these pairs of tentacles, called an 'ommatophore' or eyestalk. And, as you can see, they can fully RETRACT (evert) them at will.
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Tera Levin @teralevin.bsky.social · 28/03/2025
💐 To NIH and NSF program officers, and anyone else trying to keep those institutions alive: Thank you for trying to do an impossible job in an impossible time. I’m sorry for all of us that this is the world we’re living in. 1/n
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Jeremy Berg @jeremymberg.bsky.social · 26/03/2025
New story about grant terminations in Pittsburgh www.post-gazette.com/business/hea... 1/2
post-gazette.com
Three more Pitt researchers lose NIH funding
‘I don’t understand the politics.’
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Tom Kindlon @tomkindlon.bsky.social · 20/03/2025
🧵 From Medscape (widely read by health professionals): "What Not to Say to People With Complex Chronic Illness" www.medscape.com/viewarticle/... (may require free registration) #MEcfs #LongCovid 1/
Medscape Medical News

What Not to Say to People With Complex Chronic Illness
Miriam E. Tucker
March 18, 2025

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For people with complex chronic diseases such as long COVID, myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), and dysautonomia, a clinician’s inadvertently hurtful language can compound suffering and derail effective communication.

photo of  Dr Svetlana Blitschteyn
Svetlana Blitshteyn, MD
To address this, Svetlana Blitshteyn, MD, a neurologist who is the director of Dysautonomia Clinic at Jacobs School of Medicine and Biomedical Sciences, University of Buffalo, and Nancy J. Smyth, PhD, professor and former dean at the School of Social Work, University at Buffalo, both in Buffalo, New York, co-authored a paper entitled Language Matters: What Not to Say to Patients with Long COVID, Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, and Other Complex Chronic Disorders. In it, they provided a table of 16 “never words” that clinicians should avoid saying to patients, explanations of why the phrases are problematic, and proposed alternatives for more effective and empathetic communication.
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Jake Wintermute @synbio1.bsky.social · 03/03/2025
I know that the mRNA is larger than the protein it codes for but I don't believe it
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Jeremy Berg @jeremymberg.bsky.social · 17/03/2025
If you are wondering why universities and academic medical centers seem so stressed, one major reason is these imposed cash flow challenges. These funds were expected in good faith (and based on past practices), but have not been forthcoming. 12/n
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Jeremy Berg @jeremymberg.bsky.social · 10/03/2025
Why wouldn't you want to understand vaccine hesitancy?(Gift link) wapo.st/3Dw7WG0
wapo.st
NIH to terminate or limit grants related to vaccine hesitancy and uptake
The order covers more than 40 awards to researchers around the country seeking to understand why vaccine acceptance has declined.
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Jeremy Berg @jeremymberg.bsky.social · 09/03/2025
Bluetorial: Women, courage, and leadership What follows will include some generalizations based on population averages of what I have experienced over the course of my career. There are, of course, exceptions in every group who are substantially more to one extreme or the other.
media.tenor.com
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Jeremy Berg @jeremymberg.bsky.social · 02/03/2025
New post with the WTAE Pittsburgh news story www.wtae.com/article/pitt...
wtae.com
Pittsburgh biomedical research funding hit hard by Trump policies, warns former NIH director
Berg explained that President Donald Trump's first tactic to halt biomedical research came with a general federal funding freeze, which a judge later reversed. His second tactic: Not updating the Fede...
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John Prensner @johnprensner.bsky.social · 24/02/2025
#Microproteins may be the next frontier in #proteomics. But figuring out the publications can be tough. If you are looking for some advice about microprotein evidence, check out the latest from our consortium. Lead by @carvunis.bsky.social and Aaron Wacholder! 🧬 💻 #genomics #RNASky bit.ly/4bgJSDm
bit.ly
Detection of human unannotated microproteins by mass spectrometry-based proteomics: a community assessment
Thousands of short open reading frames (sORFs) are translated outside of annotated coding sequences. Recent studies have pioneered searching for sORF-encoded microproteins in mass spectrometry (MS)-ba...
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bioZone @thebiozone.bsky.social · 23/02/2025
Ever see dark grey slime on your faucet? Its from bacteria munching on manganese! watch on YouTube to support us 👇 youtube.com/shorts/7AULY...
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Jeremy Berg @jeremymberg.bsky.social · 22/02/2025
Bluetorial: The path to a new pain medication with little potential for addiction Perhaps a good story to share with folks who want to learn about how biomedical research works and where advances come from.
media.tenor.com
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Drug Monkey @drugmonkey.bsky.social · 22/02/2025
It’s probably a good day to explain to your non-scientist socials that graduate students are not merely the next generation of academic science, they are an important component of the current scientific labor force. Feel free to mention that this is cut rate labor as well.
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Jeremy Berg @jeremymberg.bsky.social · 20/02/2025
The press has a big role to play in shining light of what is going on...
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Office of Mayor Michelle Wu 吳弭 @mayorwu.boston.gov · 20/02/2025
The City of Boston is leading 40+ mayors, cities, and counties in an amicus brief against the Trump Administration's drastic and illegal cuts to federal research funding—cuts that will lead to immediate job losses nationwide.
COALITION OF MAYORS ACROSS U.S. FILE AMICUS BRIEF IN OPPOSITION TO TRUMP ADMINISTRATION’S DRASTIC CUTS TO FEDERAL RESEARCH FUNDING
Led by the City of Boston, MA, City of Cleveland, OH, the Metropolitan Government of Nashville and Davidson County, TN, the Mayor of Gainesville, FL, and the Mayor of Salt Lake City, UT, over 40 mayors, cities, and counties argue that NIH cuts will cause job losses, economic disruption, and undermine U.S. competitiveness

BOSTON - Thursday, February 20, 2025 - Late yesterday, Mayor Michelle Wu co-led a coalition of Mayors from across the United States in writing and filing an amicus brief in federal district court in Boston to stop the Trump Administration's drastic and illegal cuts to federal research funding and immediate job losses in cities nationwide. Over 40 mayors, cities, and counties from across the country joined the brief. These cities are home to universities and hospitals that employ hundreds of thousands of Americans in cutting edge medical and scientific research, and the federally-funded research in these communities has made the United States the global leader in scientific discovery. The brief seeks a temporary restraining order against the Trump Administration, alongside the research universities, medical schools, hospitals, and 22 states that are plaintiffs in the three cases filed last week in federal district court.

“For decades, Congress has made a clear choice to use federally-funded research to invest in cities, build a broadly-distributed infrastructure for scientific discovery, create jobs, and drive economic growth in communities across the United States,” said Mayor Michelle Wu. “We join with cities across the country – in red states, purple states, and blue states – to stop this illegal action that will cause layoffs, lab closures, and undermine scientific progress in American cities. I thank Massachusetts Attorney General Andrea Campbell for her leadership on behalf of the research institutions of Boston.”This amicus brief is in response to the abrupt February 7, 2025 announcement by the National Institutes of Health (NIH) of an immediate reduction in funding for scientific and medical research institutions across the country. Under the NIH’s new policy, which temporarily went into effect on Monday, February 10, payments for indirect costs reimbursed to research universities would be capped at 15%, down from 30-70%. The brief makes clear that NIH funding cuts would devastate research institutions in cities across the county, cause job losses, create severe economic disruption, and undermine a critical pillar of strength and civic pride in cities across the United States. The cuts would also undermine critical medical and scientific research that residents are counting on, including cancer, diabetes, and heart disease, and jeopardize the cities’ and country’s position of global leadership on scientific advancement.
“The Gainesville community depends on this highly efficient, dependable investment of our tax dollars back into our city’s innovation economy,” said Harvey L. Ward, Mayor, City of Gainesville, Florida. “I’m glad to join other mayors in highlighting the vital role NIH funding plays in the lives of everyday hardworking American families.” 
“The breadth and diversity of this coalition highlights the devastating and widespread impact of these NIH funding changes, from Alzheimer’s research to cancer clinical trials,” said Jill Habig, Founder and CEO of Public Rights Project. “We’re proud to partner with mayors, cities, and counties in opposing this threat to critical federal funding and the health and vitality of our communities.”
On Monday, February 10th, twenty two states and associations of medical schools, hospitals, and universities, filed three related cases, and secured a temporary restraining order preventing the Trump Administration from slashing the reimbursement rates. That initial order will be revisited this week in a hearing scheduled for Feb. 21.The Public Rights Project served as amici counsel. The full list of mayors, cities and counties who joined the brief is below. 



Local Governments and Mayors



City of Boston, Massachusetts
City of Cleveland, Ohio
Harvey L. Ward, Mayor, City of Gainesville, Florida
Metropolitan Government of Nashville and Davidson County, Tennessee
Erin Mendenhall, Mayor, City of Salt Lake City, Utah
City of Alameda, California
City of Albuquerque, New Mexico 
Allegheny County, Pennsylvania
City of Baltimore, Maryland 
Emma Mulvaney-Stanak, Mayor, City of Burlington, Vermont
Township of Canton, Michigan
Town of Chapel Hill, North Carolina
City of Chicago, Illinois 
Sandra Welch, Mayor, City of Coconut Creek, Florida
City of Columbus, Ohio
City of Easthampton, Massachusetts
Daniel Biss, Mayor, City of Evanston, Illinois
City of Fairfax, Virginia
Harris County, Texas
Ravinder S. Bhalla, Mayor, City of Hoboken, New Jersey
Quinton Lucas, Mayor, Kansas City, Missouri
Indya Kincannon, Mayor, City of Knoxville, Tennessee
City of Madison, Wisconsin
Jeff Silvestrini, Mayor, City of Millcreek, Utah
Anissa Welch, Mayor, City of Milton, Wisconsin
Montgomery County, Maryland
City of New Haven, Connecticut
Dontae Payne, Mayor, City of Olympia, Washington 
Adrian O. Mapp, Mayor, City of Plainfield, New Jersey
Sue Noack, Mayor, City of Pleasant Hill, California
City of Pittsburgh and Ed Gainey, Mayor, City of Pittsburgh, Pennsylvania
City of Providence, Rhode Island 
John Clark, Mayor, Town of Ridgway, Colorado
City of Rochester, New York
City of Sacramento, California 
City and County of San Francisco, California
City of Santa Monica, California
Constantine H. Kutteh, Mayor, City of Statesville, North Carolina
Lisa Brown, Mayor, City of Spokane, Washington
Tishaura O. Jones, Mayor, City of St. Louis, Missouri 
City of St. Paul, Minnesota
Dennis R. McBride, Mayor, City of Wauwatosa, Wisconsin
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Lucia Peixoto @sciencenlucia.bsky.social · 20/02/2025
I find it interesting that the response seems to first question my expertise/experience. That is called gaslighting. YES I have been on a variety of situations in which merit is assessed, including committees and study sections. I have many anecdotes as well. But anecdotes are not data
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Lucia Peixoto @sciencenlucia.bsky.social · 19/02/2025
CZI has officially bailed. I have to say one of the most disappointing aspects of all of this has been seeing how many were only doing performative DEI and never really cared about diversity equity or inclusion
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Justin Bollinger @bollinger.bsky.social · 16/02/2025
I am actively looking for a research scientist position or research administration role within the Raleigh-Durham (RDU) area! Please reach out if my background and skillset might fit your labs needs :-) Lots of experience with preclinical models, translational neuroscience, and behavioral analyses!
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Jayme McReynolds @jaymemcreynolds.bsky.social · 16/02/2025
So a former postdoc from our department had just started as a PO at NIH and was terminated in the wave of terminations last week. He is in the research triangle and a phenomenal scientist with expertise in stress and glia. If anyone in the RTI is hiring asap please let me know! #neuroskyence
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Jeremy Berg @jeremymberg.bsky.social · 16/02/2025
Thanks to all of the NIHers and their friends who reached out to me. I am still here (DM me or Signal jeremymberg.78) I still have a very incomplete picture but based on what I have been told, the damage to NIH and to many wonderful people who work(ed) there is/was impossible for me to imagine 1/n
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Jeremy Berg @jeremymberg.bsky.social · 15/02/2025
Rumors are that “it” is likely to happen Tuesday, but no one is sure was “it” is. Prepare and push back any way you can. Senators and reps, especially in red states, need to know how much we think is at stake, not for us but for everybody in the US and the world. cont..
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✨Malaika ✨ @maliqa.bsky.social · 14/02/2025
To bee or not to bee?
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Jeremy Berg @jeremymberg.bsky.social · 15/02/2025
ATTENTION (PLEASE SHARE) If anyone has or knows of any positions that might be appropriate for the NIH staff members who were terminated, please post the information in this thread. There are lots of talented and accomplished people who may be looking for new opportunities.
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Susanne Ahmari @ahmarilab.bsky.social · 14/02/2025
OK Yinzers- it's time to stand up for science!!! I will be at Schenley Plaza TODAY AT 5PM. 🙏 please join me there! We need to let people know what's happening!🙏 And yes, I know it's Valentine's Day #StandupForScienceWithYourSweetie 💗💕🧑‍🔬👨‍🔬👩‍🔬💕 💗 Please repost and do something similar at your campus!🧪
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Evolution Meetings @evolmtg.bsky.social · 13/02/2025
It’s Evolution as We Know It (And We Feel Fine)! (With apologies to REM) Registration for Evolution 2025 is now open! Join us virtually May 29-30, in-person June 20-24. www.evolutionmeetings.org/registration... @sse-evolution.bsky.social @systbiol.bsky.social @asn-amnat.bsky.social #Evol2025
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Mike Feigin 🥯 @mikefeigin.bsky.social · 11/02/2025
March 7. Stand Up For Science. Rallies in DC and nationwide. 🧪 Please visit the website and spread the word. www.standupforscience2025.org
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Anne-Ruxandra Carvunis @carvunis.bsky.social · 11/02/2025
🔎microproteins special issue!
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Jeremy Berg @jeremymberg.bsky.social · 09/02/2025
HEADS UP: ALL INDIVIDUALS WITH ACTIVE DIVERSITY-RELATED AWARDS (ANY MECHANISM) It occurred to me while out walking that it might be worth asking your PO about an extension to allow you time to apply to a non-diversity award. I don't know what the answer will be, but it is worth the ask.
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Anne-Ruxandra Carvunis @carvunis.bsky.social · 09/02/2025
Thank you Keystone, Thomas Martinez, Lena Ho, and every single attendee. It was a magical few days of world-class 🧪 microprotein science in the spirit of curiosity, rigor, respect and daring to dream big. I'm grateful for the warmth and inclusiveness of this community, especially in "these times".
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Jeremy Berg @jeremymberg.bsky.social · 07/02/2025
Assembling information about individuals affected by this may be an important first step in moving forward to try to address this injustice. THANK YOU AND PLEASE SHARE THIS THREAD
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