Selectivity is an essential part of organic synthesis and key to synthetic efficiency. However, selectivity is challenging to achieve in hydrocarbon molecules. Herein we report a mild and direct meth....

Hydroazidation of alkenes provides a direct entry to alkyl azides which are prevalent structural motifs in medicine development and chemical biology probes. Here the authors report a photocatalytic an...

Cyclopropanes, especially those substituted with trifluoromethyl (CF3) groups, are valuable scaffolds in medicinal chemistry. Their enhanced bioavailability contributes to the widespread presence of ....

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Here we report the use of a tetrabutylammonium decatungstate (TBADT)/thiol photocatalytic system for selective addition of acetone and other simple ketone, nitrile, and chlorocarbon functionalities to terminal olefins. This system avoids the use of energetic reagents such as peroxides and proceeds under mild conditions using Earth-abundant element catalysts, providing a sustainable approach to C–C bond formation using activated olefins. Initial exploration reveals that hydroalkylation of unactivated olefins is also possible, though in lower efficiency, and preliminary mechanistic experiments are consistent with a radical mechanism.

Ligand-to-metal charge transfer (LMCT) is a mechanistic strategy that provides a powerful tool to access diverse open-shell species using earth abundant elements and has seen tremendous growth in rece...

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For those outside of Rice University, please fill out the details below if you're interested in virtually attending my thesis defense! :) I'll send you an email with the Zoom link, and (hopefully) a r...

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Elixir Sulfanilamide was a breakthrough antibiotic—until it killed more than 100 people.

Adding fluorine to drug molecules can be tricky, but is often worthwhile. Rachel Brazil talks to the chemists trying to tame the ninth element

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Surfactants are amphiphilic molecules that can form micellar structures with a hydrophobic core and a hydrophilic corona in water. In this work, we combine the remarkable properties of photoactive met...

Methods for the anti-Markovnikov-selective hydrochlorination of unsaturated C–C bonds are limited by the need for stoichiometric reagents, highly oxidizing photocatalysts and multiple synthetic steps....

Iron-catalyzed reaction functionalizes less-favored positions with less fuss

Iron-catalyzed reaction functionalizes less-favored positions with less fuss

Methods for the anti-Markovnikov-selective hydrochlorination of unsaturated C–C bonds are limited by the need for stoichiometric reagents, highly oxidizing photocatalysts and multiple synthetic steps....

Methods for the anti-Markovnikov-selective hydrochlorination of unsaturated C–C bonds are limited by the need for stoichiometric reagents, highly oxidizing photocatalysts and multiple synthetic steps....

Research Corporation for Science Advancement, the Alfred P. Sloan Foundation, and The Kavli Foundation have made awards to six cross-disciplinary teams of early career researchers in the first year of...

Making homogeneous catalysis greener is about more than just swapping out precious metals for earth-abundant ones

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Fluoroalkyl fragments are ubiquitous motifs in pharmaceuticals and agrochemicals, but their introduction to a given molecule typically involves expensive or difficult-to-handle reagents. Now, the phot...

Ligand-to-metal charge transfer (LMCT) is a mechanistic strategy that provides a powerful tool to access diverse open-shell species using earth abundant elements and has seen tremendous growth in rece...

Asymmetric hydrogenation of activated olefins using transition metal catalysis is a powerful tool for synthesis of complex molecules, but traditional metal catalysts have difficulty with enantioselect...

"Fund people not projects" is easier said than done. A better way to fund science is to bend over backward to fund a truly diverse range of people and ideas, even including those perceived as unpopula...

The Department of Chemistry in the College of Arts and Science at the University of Saskatchewan (USask) is pleased to invite applications for a Tier ...