iiinova — where your digital self keeps evolving

brainresilience.bsky.social @brainresilience.bsky.social · 13/08/2026

Stanford researchers unmasked a profound breakdown in the body’s internal garbage clearance system. This targeted intervention halted chronic inflammation and preserved the functional youthfulness of multiple vital organs throughout the body. Read more: neurosciencenews.com/macrophage-e...

Targeting the pro-inflammatory EP2 receptor on tissue-resident macrophages restores the clearing of senescent neutrophils, successfully reducing systemic inflammaging to preserve youthfulness across the brain, liver, heart, and skeletal muscles. Credit: Neuroscience News

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brainresilience.bsky.social @brainresilience.bsky.social · 06/08/2026

The brain's immune system has long been thought to operate largely independently from the rest of the body. New research finds immune cells from the blood can enter the human brain during aging and transform into specialized microglia. Learn more: brainresilience.stanford.edu/news/aging-b...

Postdoctoral Fellow Julia Belk and a colleague conduct research in the Jaiswal Lab.

An illustration of the brain (in green and yellow) connected to the blood vessels of the body (in red). Image credit: Emma Vidal.

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brainresilience.bsky.social @brainresilience.bsky.social · 30/07/2026

Meet Heankel Lyons @heankel.bsky.social, a 2026 Brain Resilience Postdoctoral Scholar @stanfordbrain.bsky.social. In the Gitler Lab, she studies how the protein TDP-43 regulates gene expression in motor neurons and how disruptions in this process relate to neurodegenerative disease.

Heankel Lyons, Neurosciences Postdoctoral Scholar, Brain Resilience Track, Department of Genetics

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brainresilience.bsky.social @brainresilience.bsky.social · 22/07/2026

Over 3.4B people live with neurological conditions, making brain disorders a leading cause of global disability. #WorldBrainDay highlights the importance of brain health for all. It supports our goal to learn how brains stay healthy with age through interdisciplinary research.

Image description: Visualization of cells colored by cell type in a coronal section of the mouse brain. This visualization was made possible by spatial tagging of gene activity that allowed cell types to be identified within their spatial context in the brain. Credit: Anne Brunet Lab.

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brainresilience.bsky.social @brainresilience.bsky.social · 13/07/2026

Why do some cells die in ALS but not others? Knight Initiative researchers Olivia Gautier and Jacob Blum of the Gitler Lab have identified molecular changes in vulnerable neurons that could point to new treatments for amyotrophic lateral sclerosis (ALS). brainresilience.stanford.edu/news/why-do-...

Olivia Gautier (left) and Jacob Blum (right) of the Aaron Gitler Lab.

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brainresilience.bsky.social @brainresilience.bsky.social · 09/07/2026

Meet Emmy Li, a 2026 Brain Resilience Postdoctoral Scholar at @stanfordbrain.bsky.social. In Stanley Qi's lab (@stanleyqilab.bsky.social), she studies how the immune system interacts with the aging brain, and how these interactions may contribute to neurodegenerative diseases such as Alzheimer’s.

Emmy Li, Neurosciences Postdoctoral Scholar, Brain Resilience Track, Department of Bioengineering

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brainresilience.bsky.social @brainresilience.bsky.social · 29/06/2026

Scott A. Small, Director of the Alzheimer’s Disease Research Center (ADRC) and neurologist at @columbiamed.bsky.social, discussed his lab’s research on endosomal recycling and Alzheimer’s disease, highlighting its therapeutic potential at a recent special seminar.

Scott A. Small of Columbia University discussed his lab’s research on endosomal recycling and Alzheimer’s disease, highlighting its therapeutic potential at a special seminar by the Knight Initiative.

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brainresilience.bsky.social @brainresilience.bsky.social · 10/06/2026

This week, Margaret ("Peggy") Goodell @goodell-lab.bsky.social of Baylor College of Medicine discussed her lab's research in a talk titled "Somatic Mosaicism and Aging: Cause, Consequence, or Clock?" at an Aging Research Seminar. Thanks, Dr. Goodell, for the insightful talk, and to all who joined!

Margaret ("Peggy") Goodell of Baylor College of Medicine discussed her lab's research in a talk titled "Somatic Mosaicism and Aging: Cause, Consequence, or Clock?" at an Aging Research Seminar.

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brainresilience.bsky.social @brainresilience.bsky.social · 03/06/2026

Meet Ja Eun Choi, a 2026 Brain Resilience Postdoctoral Scholar. In Neir Eshel’s lab, she studies how sleep disruption affects mood and behavior, and why the aging brain becomes more vulnerable to stress.

Ja Eun Choi, Neurosciences Postdoctoral Scholar, Brain Resilience Track, Department of Psychiatry

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brainresilience.bsky.social @brainresilience.bsky.social · 20/05/2026

We’re happy to announce a new $90M gift from Phil and Penny Knight to extend the Knight Initiative's work at @stanfordbrain.bsky.social. This generous gift will expand our community and advance research in dementia, healthy brain aging, and resilience. Learn more: news.stanford.edu/stories/2026...

Kang Shen (left), the Vincent V.C. Woo Director of the Wu Tsai Neurosciences Institute, and Tony Wyss-Coray (right), the Knight Initiative director. Photo credit: Ola Hopper.

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brainresilience.bsky.social @brainresilience.bsky.social · 11/05/2026

Our Year-End Symposium and Research Showcase is tomorrow! We are excited to host esteemed speakers in the field, including Nir Barzilai (@nirbarzilaimd.bsky.social), Anne Brunet (@brunetlab.bsky.social), Takeshi Uenaka (@tuenaka.bsky.social), Ivan Soltesz, and Katrin Andreasson.

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brainresilience.bsky.social @brainresilience.bsky.social · 06/05/2026

This May seminar shared ongoing studies from our community: Caitlin Taylor—Histone deacetylase inhibition expands cellular proteostasis repertoires to enhance neuronal stress resilience. Xiqian Jiang—Dissecting Pathologic Circuits in Parkinson's Disease to Develop Cell-Type-Specific Therapeutics.

Caitlin Taylor, a postdoc in Kang Shen's lab, shared new findings in her talk, "Histone deacetylase inhibition expands cellular proteostasis repertoires to enhance neuronal stress resilience."

Photo by Julia Diaz.

Caitlin Taylor, Postdoc in Kang Shen Lab. Closeup.

Photo by Julia Diaz.

Xiqian Jiang, a research scientist in Mark Schnitzer's lab, discussed his ongoing research in his talk, "Dissecting Pathologic Circuits in Parkinson's Disease to Develop Cell-Type-Specific Therapeutics."

Photo by Julia Diaz.

Xiqian Jiang, a research scientist in Mark Schnitzer's lab. Close up.

Photo by Julia Diaz.

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brainresilience.bsky.social @brainresilience.bsky.social · 28/04/2026

Vadim Gladyshev of @harvardmed.bsky.social discussed "Targeting Aging and Rejuvenation" at an Aging Research seminar organized by the Knight Initiative and the Paul F. Glenn Center for Biology of Aging Research.

Close-up photo of Vadim Gladyshev. Vadim Gladyshev gives a talk on "Targeting Aging and Rejuvenation" at the April 2026 Aging Research Seminar. Photo by Julia Diaz.

Vadim Gladyshev stands in front of an audience with a title slide "Aging, Longevity and Rejuvenation." Vadim Gladyshev gives a talk on "Targeting Aging and Rejuvenation" at the April 2026 Aging Research Seminar. Photo by Julia Diaz.

Vadim Gladyshev discusses emerging research from his lab to a full audience. Vadim Gladyshev gives a talk on "Targeting Aging and Rejuvenation" at the April 2026 Aging Research Seminar. Photo by Julia Diaz.

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brainresilience.bsky.social @brainresilience.bsky.social · 17/04/2026

Stanford neurologists Michael Greicius and Victor Henderson explain what science knows about why women develop Alzheimer’s disease at higher rates than men—and the many things science doesn’t yet know. Learn more: med.stanford.edu/news/insight...

Michael Greicius, Stanford Neurologist, Knight Initiative for Brain Resilience Steering Committee member, and founding director of the Stanford Memory Disorders Center.

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brainresilience.bsky.social @brainresilience.bsky.social · 07/04/2026

Yesterday, Jordan Moore, a postdoc in the Buckwalter Lab, discussed his research, "Injectable Drug-Eluting Scaffold To Improve Cognition after Ischemic Stroke." Rahul Nagvekar @brunetlab.bsky.social shared his research in a talk, "Engulfment by brain myeloid cells of a short-lived vertebrate."

Rahul Nagvekar, a Genetics PhD candidate at Stanford University in the Brunet Lab, presents his research in a talk titled, "Engulfment by brain myeloid cells of a short-lived vertebrate."

Jordan Moore, a Postdoc at Stanford University in the Buckwalter Lab, shared his research in a talk titled, Injectable Drug-Eluting Scaffold To Improve Cognition after Ischemic Stroke."

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brainresilience.bsky.social @brainresilience.bsky.social · 01/04/2026

From rejuvenating brain plasticity with magnetic stimulation to tracking genome changes with age, Stanford researchers are exploring new paths to brain aging and resilience. The Knight Initiative is supporting 4 of 8 new seed grant projects. Read more: brainresilience.stanford.edu/news/new-ide...

An array of fifteen portraits on a green and purple striped background.

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brainresilience.bsky.social @brainresilience.bsky.social · 21/03/2026

New study on Pythons—snakes that can go a year without eating—hints at a potential weight-loss drug with fewer side effects than GLP-1 drugs. Research led by the Long Lab at Stanford and supported in part by the Knight Initiative. Learn more: brainresilience.stanford.edu/news/study-p...

Pythons produce a hunger-suppressing molecule called pTOS after meals. The same molecule tells human and mouse brains it's time to stop eating.

Image description: Yellow python with a black background.

Image credit: Denis Doukhan/Pixabay.

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brainresilience.bsky.social @brainresilience.bsky.social · 11/03/2026

Ongoing research explores how epilepsy-like activity may influence the spread of Alzheimer’s pathology in the brain. This work is led by Brain Resilience Postdoc Scholar Annie Goettemoeller in the Soltesz Lab @stanfordmedicine.bsky.social. Learn more: brainresilience.stanford.edu/news/qa-prob...

Annie Goettemoeller, a Wu Tsai Neurosciences Institute Postdoctoral Scholar supported by the Knight Initiative for Brain Resilience, in her lab.

Annie Goettemoeller looks through a microscope in her lab. Photo by Andrew Brodhead.

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brainresilience.bsky.social @brainresilience.bsky.social · 03/03/2026

In our monthly seminar, Julian Garcia of the Wendy Liu Lab presented his research in a talk titled "The Light Side of the Force." Meena Chakraborty of the Bhatt Lab discussed her research, "The gut-immune-brain connection in Parkinson's Disease," with lab mates Bianca Palushaj and Imani Porter.

Meena Chakraborty, PhD Candidate, Stanford University, presents her research at the March 2026 Brain Resilience Seminar.

Bianca Palushaj presents her research at the March 2026 Brain Resilience Seminar.

Imani Porter presents her research at the March 2026 Brain Resilience Seminar.

Julian Garcia, Brain Resilience Postdoc, shared his research in a talk titled "The light side of the force."

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brainresilience.bsky.social @brainresilience.bsky.social · 23/02/2026

Degradation-resistant proteins pass from neurons to glial cells in a process that may spread protein clumps around the brain, according to a study in mice. Read the full story by @thetransmitter.bsky.social here: www.thetransmitter.org/aging/aging-...

Courtesy of Ian Guldner, Stanford University

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brainresilience.bsky.social @brainresilience.bsky.social · 03/02/2026

In yesterday's monthly seminar, Kit Vodehnal of the Wernig Lab discussed "Neuron-glia interactions in regulating protein aggregation in human cell models," and Birgitt Schuele, an associate professor of pathology, shared "Neurodegeneration across Borders: Resilience, Fieldwork, and Gene Therapy."

Kit Vodehnal, a neurosciences PhD candidate in the lab of Marius Wernig, presented their research in a talk titled "Neuron-glia interactions in regulating protein aggregation in human cell models."

Birgitt Schuele, an associate professor at Stanford Medicine: Department of Pathology, discussed emerging research about "Neurodegeneration across Borders: Resilience, Fieldwork, and Gene Therapy."

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brainresilience.bsky.social @brainresilience.bsky.social · 27/01/2026

Our symposium is today! We look forward to scientific talks by Brit Mollenhauer of UMG, James Olzmann of @ucberkeleyofficial.bsky.social, Michael Ward of NIH, Gaurav Chattree of @stanfordhealthcare.bsky.social, Daisy Ding of @stanfordneuro.bsky.social, and Frank Longo @stanfordmedicine.bsky.social.

Text: Knight Initiative for Brain Resilience Winter 2026 Symposium.

Image collage, top row, from left: 1. Dr. Brit Mollenhauer, University Medical Center Göttingen. 2. Dr. James Olzmann, University of California at Berkeley. 3. Dr. Michael Ward, National Institutes of Health.

Bottom row, from left: 1. Dr. Gaurav Chattree, Stanford University. 2. Dr. Daisy Ding, Stanford University. 3. Dr. Frank Longo, Stanford University.

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brainresilience.bsky.social @brainresilience.bsky.social · 06/01/2026

In our first Brain Resilience Seminar of 2026, Julia Belk shared her research, "Clonal hematopoiesis and the aging brain," and Alina Isakova discussed data from the Brain Resilience Lab in a talk, "The molecular landscape of human brain aging: Known features and unexpected findings."

Julia Belk of the Jaiswal Lab gave a talk on "Clonal hematopoiesis and the aging brain." Photo by Julia Diaz.

Alina Isakova discussed data from the Brain Resilience Lab in her talk, "The molecular landscape of human brain aging: Known features and unexpected findings." Photo by Julia Diaz.

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brainresilience.bsky.social @brainresilience.bsky.social · 11/12/2025

Get alerts on the latest brain aging news, publications, datasets, and tools by subscribing to our newsletter. The first edition will go out on Dec 17 via email and LinkedIn. Subscribe via email: stanford.us11.list-manage.com/subscribe?u=... Follow on LinkedIn: www.linkedin.com/company/stan...

Photo by Alina Isakova in the Brain Resilience Lab.

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brainresilience.bsky.social @brainresilience.bsky.social · 02/12/2025

Thanks to all who joined our last monthly seminar of 2025! Cindy Lin gave a talk about "Investigating regulators of GCase activity using CRISPR KO screens," and Odilia Sianto shared her research on "Nonsense-mediated decay masks cryptic splicing events caused by TDP-43 loss."

Cindy Lin shares her research on "Investigating regulators of GCase activity using CRISPR KO screens" at the Knight Initiative for Brain Resilience monthly seminar.

Odilia Sianto shares her research on "Nonsense-mediated decay masks cryptic splicing events caused by TDP-43 loss" at the Knight Initiative for Brain Resilience monthly seminar.

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brainresilience.bsky.social @brainresilience.bsky.social · 26/11/2025

Amyotrophic lateral sclerosis and frontotemporal dementia are devastating neurodegenerative diseases. Knight Initiative postdoc Yi Zeng is finding the role a protein plays in both, and whether it can lead to new diagnostics and treatments. Learn more: brainresilience.stanford.edu/news/qa-key-...

Aaron Gitler, Tetsuya Akiyama, Yi Zeng, Chang Liu, Anastasia Lovchykova, Stephanie Rayner, Caiwei Guo, Odilia Sianto

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brainresilience.bsky.social @brainresilience.bsky.social · 20/11/2025

Gummy clumps called amyloid plaques have long been the focus of Alzheimer’s therapies. But some Stanford neuroscientists are focusing on the stringy tangles of a protein called tau, the unsung second hallmark of Alzheimer’s. Learn more: med.stanford.edu/news/insight...

A microscopic view of a neuron with a neurofibrillary tangle. Photo credit: Shutterstock/Jose Luis Calvo

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brainresilience.bsky.social @brainresilience.bsky.social · 15/11/2025

From molecular atlases of aging to emerging ideas about immune pathways, synapses, and glial biology, scientists from Stanford, @ucsfhealth.bsky.social, @ucl.ac.uk, and @alleninstitute.org shared new brain resilience research at our recent symposium. 🔗 brainresilience.stanford.edu/news/mind-bl...

Isabella Elkinbard presents research she conducted in the lab of Wu Tsai Neuro affiliate and Stanford Medicine Assistant Professor of Neurosurgery Vivek Buch.

Hongkui Zeng gives a talk on "Dynamic changes of brain cell types in development and aging."

Knight Initiative Brain Resilience Lab Director Alina Isakova describes her team's efforts.

Soyon Hong gives a talk on "Neuro-glia-immune crosstalk conferring synapse vulnerability in neurodegeneration."

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brainresilience.bsky.social @brainresilience.bsky.social · 10/11/2025

“We’re making a helmet people can wear that delivers ultrasound to the brain, and we plan to initiate clinical testing of this protocol in the next few months,” said Raag Airan. With Knight Initiative support, they plan to test it on people soon. 🔗 brainresilience.stanford.edu/news/new-ult...

Raag Airan, Matine Azadian, Payton Martinez and Yun Xiang in the lab. Azadian is holding a version of their ultrasound apparatus designed for humans.

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brainresilience.bsky.social @brainresilience.bsky.social · 05/11/2025

Fantastic talks at yesterday's seminar! Ted Wilson - Unveiling early Alzheimer’s: biomarkers and breakthroughs on the path to brain resilience. Raag Airan - Ultrasonic debris clearance for improving neurofluid flow and decreasing neuroinflammation.

Ted Wilson shared his research on "Unveiling early Alzheimer’s: biomarkers and breakthroughs on the path to brain resilience," at our monthly seminar series.

Raag Airan gave a talk on "Ultrasonic debris clearance for improving neurofluid flow and decreasing neuroinflammation" at the Knight Initiative's monthly seminar.

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brainresilience.bsky.social @brainresilience.bsky.social · 13/10/2025

Thank you to our wonderful speakers and everyone who joined us at the Fall 2025 Symposium and Poster Session! It was a day full of insights into the latest research on healthy brain aging, resilience, and various neuroscience studies at Stanford.

Audience members listen attentively to a speaker with research posters in the background.

Attendees Tolu Oyeniyi and Veronica Augustina Bot network at the symposium poster session.

David Seong discusses his research from the lab of Nima Aghaeepour at the symposium poster session.

Aaron Gitler, a Stanford Medicine Basic Science Professor in the Department of Genetics and a member of the Knight Initiative Steering Committee, and Elizabeth Mormino, an associate professor (research) of neurology and neurological sciences (neurology research), smile for the camera at the symposium poster session.

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brainresilience.bsky.social @brainresilience.bsky.social · 09/10/2025

Our Fall Symposium is today! We look forward to our poster session and talks by: John W. Day, Soyon Hon @soyonhonglab.bsky.social, Alina Isakova, Andrew C. Yang, Hongkui Seng @hongkuizeng.bsky.social, and Xuchen Zhang.

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brainresilience.bsky.social @brainresilience.bsky.social · 08/10/2025

Great talks at our recent seminar! Featuring: Kristy Zera - Blocking the VLA4/VCAM1 axis prevents infarct-induced neurodegeneration by reducing neuroinflammation & promoting vascular integrity Carla Shatz - Convergence of signals for pruning at a synaptic receptor implicated in Alzheimer's Disease

Dr. Kristy Zera gave a talk on “Blocking the VLA4/VCAM1 axis prevents infarct-induced neurodegeneration by reducing neuroinflammation and promoting vascular integrity" at the monthly Brain Resilience Seminar Series.

Dr. Carla Shatz gave a talk on “Convergence of signals for pruning at a synaptic receptor implicated in Alzheimer's disease" at the monthly Brain Resilience Seminar Series.

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brainresilience.bsky.social @brainresilience.bsky.social · 25/09/2025

Join us on Oct 9 at a symposium featuring brain resilience and aging research, including a clinical presentation with a patient’s perspective, poster session, and social! Registration required. Stanford affiliates, sign up to present a poster by Oct 2. brainresilience.stanford.edu/events/knigh...

Text: Knight Initiative for Brain Resilience, Wu Tsai Neurosciences Institute, Stanford University. Fall 2025 Symposium and Poster Session. October 9, 2025, 12:30 PM to 6:00 PM.

Image description: Digital Pathology. Oil Red O staining of a prefrontal cortex sample. It stains neutral lipids to assess lipid pathology. (triacylglycerols and sterol esters). The lipid staining gives an idea of lipid pathology to track a feature of brain aging. The red stains are positive stains (neutral lipid aggregates within cells). One of many stains that are possible. Image credit: Brain Resilience Lab.

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brainresilience.bsky.social @brainresilience.bsky.social · 09/09/2025

Our Brain Resilience Seminars are back! Yesterday, Jacob Simon shared his research on "A novel toolset for understanding neuromodulation," and Joe Winer discussed "Effects of ⍺-synuclein pathology in normal aging and Alzheimer’s disease." Thank you to all who joined and participated in the Q&A.

Jacob Simon presents his research on "A novel toolset for understanding neuromodulation."

Joe Winer presents his research on the "Effects of ⍺-synuclein pathology in normal aging and Alzheimer’s disease."

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brainresilience.bsky.social @brainresilience.bsky.social · 05/09/2025

Syed has been a vital part of our Brain Resilience Lab as the Primary Neuroanatomist and @stanfordmedicine.bsky.social’s Primary Brain Dissectionist & Coordinator, supporting research brains and rapid brain autopsies. He’s now beginning his PhD at the University of Washington . Congrats Syed!

Syed Bukhari, Primary Neuroanatomist, Brain Resilience Laboratory

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brainresilience.bsky.social @brainresilience.bsky.social · 28/08/2025

Why do some dementia treatments work in mice but not in people? At @stanfordneuro.bsky.social, Vanessa Langness, Danielle Simmons, and Frank Longo reviewed 400+ preclinical studies to identify key differences in timing, study design, and disease stage. brainresilience.stanford.edu/news/why-pro...

Mice are often helpful for understanding human disease, yet promising tests in mice often don't translate to humans. A new study probes why.

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brainresilience.bsky.social @brainresilience.bsky.social · 20/08/2025

Researching the aging brain starts with knowing its structure. Syed Bukhari, Primary Neuroanatomist at the Brain Resilience Lab, led a hands-on anatomy workshop for Stanford researchers—sharing expertise and building connections across the brain resilience community.

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brainresilience.bsky.social @brainresilience.bsky.social · 15/08/2025

In the Brain Resilience Lab, Shon has contributed to flagship projects that map the molecular landscape of brain aging and led collaborations using next-generation sequencing, histology & spatial transcriptomics. He’s now starting his neuroscience PhD at @ucsanfrancisco.bsky.social. Congrats Shon!

Shon Alimukhamedov, Research Associate, Brain Resilience Lab

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brainresilience.bsky.social @brainresilience.bsky.social · 31/07/2025

By integrating innovative lysosomal omics and ferroptosis-targeted interventions, Dr. Monther Abu-Remaileh and Dr. Scott Dixon aim to identify strategies to restore lysosomal function, protect against neurodegeneration, and enhance brain resilience. brainresilience.stanford.edu/our-science/...

2025 Catalyst Momentum Award. Mapping the cell-type-specific lysosomal content. PI: Monther Abu-Remaileh. Knight Initiative for Brain Resilience, Wu Tsai Neurosciences Institute, Stanford University.

2025 Catalyst Momentum Award. Mapping the cell-type-specific lysosomal content. Team member: Scott Dixon. Knight Initiative for Brain Resilience, Wu Tsai Neurosciences Institute, Stanford University.

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brainresilience.bsky.social @brainresilience.bsky.social · 15/07/2025

What makes the brain resilient, and how can research help more people stay cognitively healthy as they age? Highlights include: 🧠 Early biomarkers 🧪 Lysosomal function 💉 Shingles vaccine & reduced dementia risk 📣 Lived experience 📊 72 Stanford posters brainresilience.stanford.edu/news/knight-...

Marwa Zafarullah talks about her research poster with another person.

Elizabeth Mormino speaks at the Spring 2025 Brain Resilience Symposium.

A poster session gave 72 researchers a chance to discuss their research and its potential impact.

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brainresilience.bsky.social @brainresilience.bsky.social · 09/07/2025

“We’ve developed a blood-based indicator of the age of your organs,” said Tony Wyss-Coray. “With this indicator, we can assess the age of an organ today & predict the odds of your getting a disease associated with that organ 10 years later.” Read more: med.stanford.edu/news/all-new...

Graphic design of a human body with clocks designed in place of intestines to symbolize organs aging at different speeds. Image credit: Tobias Wüstefeld.

Tony Wyss-Coray, PhD, professor of neurology and neurological sciences and director of the Knight Initiative for Brain Resilience at the Wu Tsai Neurosciences Institute

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brainresilience.bsky.social @brainresilience.bsky.social · 25/06/2025

Why do some older adults remember better than others, even when equally healthy? A new Knight-supported study led by Jintao Sheng & Anthony Wagner shows 2 distinct pathways that shape memory in aging: 🧠Early Alzheimer’s tau 🧠Moment-to-moment attention 🔗 brainresilience.stanford.edu/news/two-roa...

Brain scan images with some regions highlighted in reds and blues.

Jintao Sheng, Brain Resilience Postdoctoral Research Fellow, Psychology

Anthony Wagner, Lucie Stern Professor in the Department of Psychology, Deputy Director of Stanford’s Wu Tsai Neurosciences Institute

Elizabeth Mormino, Associate Professor, Neurology & Neurological Sciences

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brainresilience.bsky.social @brainresilience.bsky.social · 23/06/2025

Stanford scientists are uncovering the cellular functions that go awry in degenerative brain disorders and identifying therapies that could treat them in the lab of chemical engineer and Knight Initiative affiliate Monther Abu-Remaileh @abu-remaileh.bsky.social. 🔗 news.stanford.edu/stories/2025...

Monther Abu-Remaileh, Assistant Professor of Chemical Engineering and of Genetics, Institute Scholar at Sarafan ChEM-H, Knight Initiative for Brain Resilience supported researcher

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brainresilience.bsky.social @brainresilience.bsky.social · 10/06/2025

Tanya Paull of @utaustin.bsky.social gave a talk on "DNA damage and cerebellar ataxia: roles for transcription stress, PARP, and R-loops in ATM-associated neurodegeneration" in an Aging Research seminar organized by the Knight Initiative and the Paul F. Glenn Center for Biology of Aging Research.

Tanya T. Paull, Burl G. and Lorene L. Rogers Chair in Human Health, Professor of Oncology, gives a talk on "DNA damage and cerebellar ataxia: roles for transcription stress, PARP, and R-loops in ATM-associated neurodegeneration."

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brainresilience.bsky.social @brainresilience.bsky.social · 09/06/2025

What does surgery reveal about brain resilience? Anesthesiologists Martin Angst & Igor Feinstein are studying older adults before, during & after cardiac surgery to explore how stress impacts the brain—why some recover cognitively while others decline. brainresilience.stanford.edu/news/under-l...

Debbie Styles smiles with her surgical team. Standing, from left to right: Tiffany, a research coordinator for the CARDIAC-PND Study, Dr. Martin Angst, and Dr. Igor Feinstein.

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brainresilience.bsky.social @brainresilience.bsky.social · 04/06/2025

At a recent seminar, Hannah Ennerfelt shared a talk on "Peripheral immune drivers of cognitive decline in aging and Alzheimer's disease," and Jintao Sheng discussed "Top-down attention & Alzheimer’s pathology impact cortical selectivity during learning, influencing episodic memory in older adults."

Hannah Ennerfelt shares her research on "Peripheral immune drivers of cognitive decline in aging and Alzheimer's disease."

Jintao Sheng shares her research on "Top-down attention and Alzheimer’s pathology impact cortical selectivity during learning, influencing episodic memory in older adults."

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brainresilience.bsky.social @brainresilience.bsky.social · 13/05/2025

Thanks to all who joined us at our Year-End Symposium and Research Showcase to learn about promising studies on brain resilience supported by the Knight Initiative. Congratulations to Vanessa Doulames, Lauren Duan, Shuke Xiao, and Shon Alimukhamedov, the 2025 poster session winners!

Brain Resilience Community members discuss emerging research at the 2025 Year End Symposium and Research Showcase poster session.

Jian Xiong, Brain Resilience Postdoctoral Scholar, presents his research on"Pla2g15: A novel lysosomal BMP hydrolase with therapeutic potential in neurodegenerative diseases" at the Spring 2025 Symposium: Brain Resilience Research Showcase.

Brain Resilience Community members discuss their research at the symposium poster session.

2025 poster session winners: (from left) Lauren Duan, Vanessa M. Doulames, Shon Alimukhamedov, and Shuke Xiao.

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brainresilience.bsky.social @brainresilience.bsky.social · 08/05/2025

Geldsetzer shares that the findings have now been replicated in other health systems, including in Australia, using varied data sources and outcome measures. His team is now investigating why the shingles vaccine may help protect against dementia.

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brainresilience.bsky.social @brainresilience.bsky.social · 08/05/2025

Mormino shares early results from the 7-year Stanford Aging and Memory Study. With improved tools, researchers can now detect biomarkers of neurodegeneration earlier and deepen our understanding of cognitive resilience and decline.

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