Abstract. Sepsis remains a leading cause of morbidity and mortality in US hospitals despite extensive efforts to improve early recognition and treatment, p

Eosinophils are granulocytes that play a significant role in fighting infections caused by parasites. They also participate in the pathogenesis of allergic diseases. But there is increasing evidence a...

Nature Communications - Analysis of cell samples from pneumonia patients may indicate specific phenotypes associated with disease. Here the authors use a multi-omics approach to analyse...

The ongoing outbreak of Ebola virus disease (EVD) caused by Bundibugyo ebolavirus (BDBV) in the Democratic Republic of the Congo (DRC) and Uganda represents a major regional public health emergency wi...

Severe respiratory failure is the leading cause of intensive care unit (ICU) admission and mortality in critically ill COVID-19 patients. However, whe…

An outbreak in DR Congo has been declared a health emergency, with almost 250 suspected cases reported.

Age is a well-known risk factor to develop severe viral respiratory infections, including severe COVID-19. This study aimed to identify the biological alterations linked to severe disease in elderly p...

Age is a well-known risk factor to develop severe viral respiratory infections, including severe COVID-19. This study aimed to identify the biological alterations linked to severe disease in elderly p...

Severe respiratory failure is the leading cause of intensive care unit (ICU) admission and mortality in critically ill COVID-19 patients. However, whe…

Severe respiratory failure is the leading cause of intensive care unit (ICU) admission and mortality in critically ill COVID-19 patients. However, whe…

Sepsis is defined as a dysregulated host response to infection that leads to life-threatening organ dysfunction. The infectious insult triggers a dysr…

Objective Immune dysregulation plays a pivotal role in the pathophysiology of sepsis and COVID-19, with lymphopenia emerging as a consistent marker of severity and poor prognosis. However, most existi...

Abstract. Rationale: Sepsis is a leading cause of mortality and involves a dysregulated host response to infection. The host and microbe have historically

Our pathophysiological understanding of human disease fundamentally relies on our ability to make reproducible observations that demonstrate consistency an

Over three decades, randomized controlled trials (RCTs) for critical care syndromes such as acute respiratory distress syndrome (ARDS), sepsis, and community acquired pneumonia (CAP) have repeatedly p...

With its vaccine schedule, “Denmark has made a values choice to accept preventable hospitalizations and illnesses that other countries have chosen to prevent.”

Background Despite advances in treatment, critically ill COVID-19 patients requiring intensive care unit (ICU) admission continue to comprise a substantial proportion of cases. However, the factors in...

The clinical decision tool reduced antibiotic prescribing in children without causing harm. Our results support its broader dissemination and implementation to improve the management of acutely ill ch...

Intensive Care Medicine -

The 2025 Global Climate and Health Summit placed physiology and partnerships at the heart of climate and health. Read more

Citation metrics are widely used and misused. We have created a publicly available database of top-cited scientists that provides standardized information on citations, h-index, co-authorship adjusted...