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Quantitative Biology in Aging and Disease

@biologyaging.bsky.social
158 followers 212 following 9 posts

Chandra lab twitter. Opinions are personal and do not reflect Mayo Clinic. www.mayo.edu/research/faculty/chand…

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Quantitative Biology in Aging and Disease @biologyaging.bsky.social · 06/12/2025
www.linkedin.com/posts/tamir-...
linkedin.com
Introducing COMET ☄️: A Fundamental Principle of Clonal Expansion Enables Detection of Clonal Hematopoiesis from DNA Methylation | Tamir Chandra
Just put together a deep-dive on our new algorithm/work detecting clonal hematopoiesis from DNA methylation. We discovered a fundamental principle of how clonal expansion shapes epigenetic landscapes—...
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Quantitative Biology in Aging and Disease @biologyaging.bsky.social · 17/07/2025
www.linkedin.com/posts/tamir-...
linkedin.com
So much hype around clocks and their clinical utility. | Tamir Chandra
So much hype around clocks and their clinical utility. Time for an attempt at an unbiased comparison. Same cohort, 14 clocks, up to 20 years follow-up. Congratulations to Riccardo Marioni and Christos...
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Quantitative Biology in Aging and Disease @biologyaging.bsky.social · 20/06/2025
www.linkedin.com/posts/tamir-...
linkedin.com
This is the 5th study with the wonderful kidney team at the The University of Edinburgh, David Ferenbach, Bryan Conway and Laura Denby, whose passion about kidneys is catching and fully justified! | T...
This is the 5th study with the wonderful kidney team at the The University of Edinburgh, David Ferenbach, Bryan Conway and Laura Denby, whose passion about kidneys is catching and fully justified! Our...
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Governor Tim Walz @governorwalz.mn.gov · 08/04/2025
For 50 years, Voyageurs National Park has brought millions of people from around the world to see all that the Land of 10,000 Lakes has to offer - remote island camping, paddling, world-class fishing, and abundant winter activities. Happy birthday, Voyageurs!
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George Takei @georgetakei.bsky.social · 27/03/2025
Yesterday, I fondly remembered my dear friend Leonard Nimoy, who would have turned 94. His legacy lives on in our hearts. Just days ago, Bill Shatner celebrated his 94th birthday — wishing him continued health and happiness. Live long and prosper, my friends.
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Colin Semple @csemple.bsky.social · 24/03/2025
New publication from the lab! We used a machine learning approach to predict chromatin loop dynamics during human spermatogenesis - and find these structures do not direct gene expression but may drive the positioning of recombination events bmcbiol.biomedcentral.com/articles/10....
bmcbiol.biomedcentral.com
CTCF-anchored chromatin loop dynamics during human meiosis - BMC Biology
Background During meiosis, the mammalian genome is organised within chromatin loops, which facilitate synapsis, crossing over and chromosome segregation, setting the stage for recombination events and...
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Quantitative Biology in Aging and Disease @biologyaging.bsky.social · 24/03/2025
🤔
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Wolfgang Huber @wkhuber.bsky.social · 18/03/2025
This is great
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Kristina Kirschner @krikirschner.bsky.social · 07/03/2025
TUTORIAL: Our new preprint "Clinical progression of clonal hematopoiesis is determined by a combination of mutation timing, fitness, and clonal structure" is out @elatorre.bsky.social @edinunilbc.bsky.social @linusschumacher.bsky.social @biologyaging.bsky.social www.biorxiv.org/content/10.1...
biorxiv.org
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Alejo Rodriguez-Fraticelli @alejofraticelli.bsky.social · 25/02/2025
🔥 New Fraticelli lab publication🔥 “Pre-existing stem cell heterogeneity dictates clonal responses to the acquisition of leukemia driver mutations” Now at Cell Stem Cell, with two new figures, in vivo, and sequential mutagenesis data. Performed with the support of Cris Cancer and @erc.europa.eu
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Quantitative Biology in Aging and Disease @biologyaging.bsky.social · 22/02/2025
🥺
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Governor Tim Walz @governorwalz.mn.gov · 20/02/2025
NEW: Minnesota was just ranked a top state both to retire and to raise a family.   By investing in the things that matter – economic opportunity, health and safety, and strong communities – we’re building the best state for all Minnesotans from childhood through retirement.
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Governor Tim Walz @governorwalz.mn.gov · 20/02/2025
It was an honor to sign the guest book in the home of Anne Frank. I was here as a younger man and thought about her life as a dark chapter of history. Today, I can’t help but think of her story as one of caution. Our world is fragile, and it’s incumbent on us not to break it.
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Pete Buttigieg @petebuttigieg.bsky.social · 19/02/2025
First nuclear weapons management, now this. No one - Democrat or Republican - voted for this kind of incompetence.
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djmurphylab2.bsky.social @djmurphylab2.bsky.social · 19/02/2025
A little MYC goes a long way! Check out this absolute tour de force from colleagues Miryam Müller, Stephanie May, Tom Bird and team who assembled an compendium of liver cancer mouse models mirroring a spectrum of human HCC subtypes: www.nature.com/articles/s41...
nature.com
Human-correlated genetic models identify precision therapy for liver cancer - Nature
As proof of principle, an analysis using a suite of human-aligned immunocompetent mouse models of hepatocellular carcinoma identifies a promising therapeutic candidate, cladribine, which acts in ...
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Pete Buttigieg @petebuttigieg.bsky.social · 17/02/2025
The flying public needs answers. How many FAA personnel were just fired? What positions? And why?
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Magnus Rattray @mrattray.bsky.social · 15/02/2025
Interested in an early-career fellowship (within 3 years of a PhD)? Want to work at the interface of AI with biology, health or medicine? Contact me if you want support with your application www.bmh.manchester.ac.uk/research/sup...
bmh.manchester.ac.uk
Bicentenary Early Career Research Fellowships | Biology, Medicine and Health | University of Manchester
Find out about and apply for a Bicentenary Early Career Research Fellowship.
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Simon Buczacki @sibucz.bsky.social · 14/02/2025
New paper. Why do we try to remove increasingly large numbers of lymph nodes in colon cancer surgery? Here we follow up our BJC 2022 paper with ~370K patients in England and USA. Only 9 LNs are required to stage the cancer. www.nature.com/articles/s41...
nature.com
Lymph node yield as a surrogate marker for tumour biology and prognosis in colon cancer - British Journal of Cancer
British Journal of Cancer - Lymph node yield as a surrogate marker for tumour biology and prognosis in colon cancer
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Wolfgang Huber @wkhuber.bsky.social · 14/02/2025
Do you love software engineering for exciting biological applications, open science,open source, R, Bioconductor, modern web, cloud& ML technologies? We're looking for a software engineer to work on R/Bioconductor tools for biological data science and AI embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
Picture of the conference centre on the EMBL campus in Heidelberg
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Jeremy Berg @jeremymberg.bsky.social · 10/02/2025
A useful tool and a great thing to do... 5calls.org/issue/nih-ns...
5calls.org
Save NIH and NSF Research Funding ⭑ 5 Calls
On February 7, the Trump administration moved to cut billions of dollars in funding from the National Institutes of Health (NIH) and National Science …
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Governor Tim Walz @governorwalz.mn.gov · 06/02/2025
We’re focused on feeding our kids. Investing in our schools. Making sure child care is affordable. Regardless of the chaos unfolding in Washington, we’re making Minnesota the best state for kids to grow up.
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Quantitative Biology in Aging and Disease @biologyaging.bsky.social · 31/01/2025
Danke Mutti🙏🏾
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Chris Ponting @cgatist.bsky.social · 21/01/2025
What DNA variants alter transcription factor (TF) binding affinity? Here, we describe a new workflow baal-nf. We used it to trawl through 6017 ChIP-Seq data sets for 558 TFs and 46 genotyped cell lines, finding 298,783 allele-specific binding sites (ASBs). www.biorxiv.org/content/10.1... 1/2
Description of image: Workflow for identifying high-quality ASBs through baal-nf. ChIP-sequencing data from genotyped cell lines is used to infer ASBs at heterozygous SNPs using BaalChIP. Identified ASBs are further characterized by mapping them to JASPAR and NoPeak motifs for a given TF. High-quality ASBs show concordance in the corrected allelic ratio and motif score difference.
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Generation Scotland @genscot.bsky.social · 23/12/2024
Happy holidays and Happy New Year from the Generation Scotland team!🎄🎇 We had a ✨competitive✨ darts game to celebrate—check out these great pics! A huge thank you to our amazing volunteers; we’re so grateful for you and excited for 2025, with exciting research and events! We'll be back on Jan 3rd. ❤️
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Anna Abalkina @abalkina.bsky.social · 21/12/2024
This is a catastrophe. While Finland has downgraded the MDPI and Frontiers journals to level 0 (meaning these publications are not recognized for research evaluation purposes), Germany has signed an agreement to promote publications in MDPI journals.
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Mark A. Hanson @hansonmark.bsky.social · 20/12/2024
I was approached re: the Finnish decision to downgrade MDPI & Frontiers journals in 🇫🇮 rankings (THE article). This decision was based on broad patterns, including in our recent study "The strain on scientific publishing" (link: direct.mit.edu/qss/article/...) A quick 🧵 1/n #SciPub #AcademicChatter
timeshighereducation.com
Finland downgrades MDPI and Frontiers – will others follow suit?
Decision to downgrade 271 journals on quality and operating model concerns sparks debate
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Elizabeth Warren @warren.senate.gov · 17/12/2024
Just a reminder that in 2019, RFK Jr.'s anti-vaccine misinformation campaign helped cause a measles outbreak in Samoa that killed 83 people, mostly kids. Do you really want him to lead the Department of Health and Human Services?
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Elisabeth Bik @elisabethbik.bsky.social · 17/12/2024
Infamous paper that popularized unproven COVID-19 treatment finally retracted Study on hydroxychloroquine by Didier Raoult and colleagues gets pulled on ethical and scientific grounds @cathleenogrady.bsky.social reports. www.science.org/content/arti...
science.org
Infamous paper that popularized unproven COVID-19 treatment finally retracted
Study on hydroxychloroquine by Didier Raoult and colleagues gets pulled on ethical and scientific grounds
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The Lothian Birth Cohorts @edinunilbc.bsky.social · 16/12/2024
The December issue of the Disconnected Mind Newsletter from Lothian Birth Cohorts is now available online with highlights of 2024 as well as our recent research and publications, and scientific and public engagement events from this Autumn: edin.ac/3DeEOCR @schoolofppls.bsky.social
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Amy Klobuchar @amyklobuchar.com · 15/12/2024
Cancer is a common cause of line-of-duty death for firefighters. We worked across the aisle to reauthorize the Firefighter Cancer Registry so we can improve research into health and safety standards for these heroes who put their lives on the line for us every day.
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Duncan Sproul @sproullab.bsky.social · 12/12/2024
We've been awarded a UKRI MRC grant to examine the causes and consequences of #heterochromatin hypomethylation in cancer 🥳. #postdoc opportunity coming in the near future. #epigenetics. Please share with anyone who might be interested.
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Dorothy Bishop @deevybee.bsky.social · 06/12/2024
Here's Toby Young defending Elon Musk's FRS. www.spectator.co.uk/article/why-... I suspect he feels common ground: www.theguardian.com/media/2018/j... Since he says my arguments are political (they aren't) and doesn't link to my post, I wonder if he's read it. deevybee.blogspot.com/2024/11/why-...
spectator.co.uk
Why Elon Musk shouldn’t be kicked out of the Royal Society
Bishop did not wish to be associated with ‘someone who appears to be modelling himself on a Bond villain’ In a notorious interview in the Sunday Times in 2007, the Nobel Prize-winning geneticist James...
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Mirre Simons @mirresimons.bsky.social · 01/12/2024
#Phd on #Aging #Ageing available in my group. Focus is long-read sequencing and splicing after treatment with DR and mTOR suppression in flies. #drosophila www.findaphd.com/phds/project...
findaphd.com
Mechanisms of alternative splicing in neurodegeneration and ageing at University of Sheffield on FindAPhD.com
PhD Project - Mechanisms of alternative splicing in neurodegeneration and ageing at University of Sheffield, listed on FindAPhD.com
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