iiinova — where your digital self keeps evolving

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Micah @rincewind.run · 02/08/2026

I mean for fuck’s sake guys have some standards in your choice of cult leader

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Mittal Group @ TAMU @mittalgrouptamu.bsky.social · 10/07/2026

We are hiring postdoctoral researchers. Please share!

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Matteo Paloni @betterwithchem.bsky.social · 26/06/2026

Excited to share our new bioRxiv preprint with @matbocca.bsky.social and @davideerba.bsky.social! We use a minimal coarse grained model to investigate how protein-RNA binding affects RNP condensate formation. We'd love to hear your thoughts and feedback!

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bioRxiv Biophysics @biorxiv-biophys.bsky.social · 26/06/2026

Interplay Between Protein-RNA Binding and Phase Separation Drives Emergent Behavior in RNP Condensates www.biorxiv.org/content/10.64898/20…

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Mathieu M.J.E. Rebeaud @chercheurjuteux.com · 25/06/2026

Je sais pas si vous réalisez qu'on est à plus de 14°C au dessus des moyennes standards... C'est un enfer. Et on est qu'à 1.5°C de plus annuellement. Imaginez 4°C.

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Roland Dunbrack 🏳️‍🌈 @rolanddunbrack.bsky.social · 01/06/2026

I made a better one. My favorite kinase, Aurora A. Happy Pride! 🏳️‍🌈🏳️‍⚧️

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Derek Lowe @dereklowe.bsky.social · 30/04/2026

This whole thread!

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Micah @rincewind.run · 03/04/2026

Discworld QOTD, from Moving Pictures

The pass mark in Finals was 88.
Failing would be easy. Any idiot can fail.
Victor’s uncle had been no fool. One of the conditions of the legacy was that, should Victor ever achieve a mark of less than 80, the money supply would dry up like thin spit on a hot stove.
He’d won, in a way. Few students had ever studied as hard as Victor. It was said that his knowledge of magic rivaled that of some of the top wizards. He spent hours in a comfy chair in the Library, reading grimoires. He researched answer formats and exam techniques. He listened to lectures until he could quote them by heart. He was generally considered by the staff to be the brightest and certainly the busiest student for decades and, at every Finals, he carefully and competently got a mark of 84.
It was uncanny.

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Mathieu M.J.E. Rebeaud @chercheurjuteux.com · 03/04/2026

Petit résumé de Trump: 28 février : « Nous lançons une opération décisive. » « Ce sera rapide. » 2 mars : « Nous l'emporterons facilement. » 3 mars : « Nous avons gagné la guerre. » 7 mars : « Nous avons vaincu l'Iran. » 9 mars : « Nous devons attaquer l'Iran. »

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Larry the Cat @number10cat.bsky.social · 24/02/2026

Four years ago Russia began it's full scale invasion of Ukraine. They expected it to fall in days. They were wrong. Long live Ukraine.

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Center for Structural Biology (CBS Montpellier) @cbsmontpellier.bsky.social · 18/02/2026

Discover and share the CBS Montpellier starter pack, to follow current and formers members of the Centre de Biologie Structurale on Bluesky. go.bsky.app/G682pvP @cnrs.fr @inserm.fr @umontpellier.bsky.social

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Norm DePlume @normdeplume.bsky.social · 29/01/2026

Hannah Arendt did not mince words, did she? 'Totalitarianism replaces all first-rate talents with crackpots and fools whose lack of intelligence and creativity is still the best guarantee of their loyalty.' From "The Origins of Totalitarianism" (1951)

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Eileen Ridge @eileen4ever.bsky.social · 28/01/2026

Holy moly this chart: Cumulative US measles cases

Cumulative US measles cases
As of January 27, there have been more cases than there were by the same week last year.
Fairly horizontal lines for 2023 and 2024, a steep diagonal line for 2025, and a vertical line for ytd 2026.
2026
478 cases
2025
2253 cases
2024
283 cases
2023
63 cases
Note: Data updated on January 27, 2026, at 3 p.m. ET.
Source: Centers for Disease Control and Prevention; Johns Hopkins University, Center for Outbreak Response Innovation Graphic: Alex Leeds Matthews and Matt Stiles, CNN

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Évariste Galois @evaristegal01s.bsky.social · 26/01/2026

Bo, io la riposto, tanto non serve a un cazzo. Ormai è una tombola demoniaca.

Un riassunto dei segnali d'allarme del fascismo di Umberto Eco

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Barack Obama @barackobama.bsky.social · 25/01/2026

The killing of Alex Pretti is a heartbreaking tragedy. It should also be a wake-up call to every American, regardless of party, that many of our core values as a nation are increasingly under assault.

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Olga Nesterova @onestpress.onestnetwork.com · 25/01/2026

Minnesota National Guard members have arrived at a federal building and were directed to distribute donuts, coffee, and hot chocolate to anti-ICE protesters. Guard members were issued reflective vests so they would not be mistaken for federal agents.

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Dave Byrnes @djbyrnes1.bsky.social · 25/01/2026

The march is now passing the Chicago city hall / Cook County hall building. The chant goes up, "Minnesota don't you fear, we, the people, are right here"

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Katie Mack @astrokatie.com · 25/01/2026

A reminder to the news media: “conflicting accounts” is what you say BEFORE the incontrovertible video evidence appears. After that, your job is to ask why one side is lying, not to repeat the lie and pretend no one knows the truth.

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Stefano Zanero @raistolo.bsky.social · 17/01/2026

Literally every single thing in here was astonishingly evident from the beginning.

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Évariste Galois @evaristegal01s.bsky.social · 03/01/2026

"Coerentemente con la posizione storica della Presidente del consiglio diremo qualcosa senza dire niente, contraddicendoci in meno di 200 caratteri".

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bioRxiv Biophysics @biorxiv-biophys.bsky.social · 24/12/2025

Evidence for the Progressive Improvement of All-Atom Force Fields in Reproducing Local Conformational Preferences of Flexible Peptides www.biorxiv.org/content/10.64898/20…

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Bussi Lab @bussilab.org · 28/11/2025

🎉Our group has been awarded a prestigious #FIS grant! #RNAScale - Exploring RNA Dynamics across Scales: From Base Pairs to Viral Genomes 👉 www.bussilab.org/fis3 We will soon open postdoctoral positions across several components of the project! An expression-of-interest form is already online.

bussilab.org

RNAScale

Exploring RNA Dynamics across Scales

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Mathieu M.J.E. Rebeaud @chercheurjuteux.com · 15/11/2025

Un candidat pour la photo de 2025 sur ce que deviennent les US.

Faith leader, Michael Woolf, minister at Lake Street Church of Evanston, is detained by Illinois State Police during a protest against immigration actions, outside the Broadview ICE facility in Chicago, Illinois, U.S., November 14, 2025. REUTERS/Jim Vondruska

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Matteo Paloni @betterwithchem.bsky.social · 07/11/2025

Great opportunity with a great mentor!

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Mathieu M.J.E. Rebeaud @chercheurjuteux.com · 19/10/2025

Vous avez besoin de voir la fanfare des potichats Mitchiri, pour la santé mentale et pour trouver tous les chats qui font nawak pendant la marche. youtu.be/lAIGb1lfpBw?...

youtu.be

みっちりねこマーチ - MitchiriNeko March - Cute cat characters in a marching band!

YouTube video by Mitchiri MitchiriNeko (みっちりねこ)

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Elisa Fadda @elisafadda.bsky.social · 16/10/2025

Students don't pay top £$€ for "information" they pay to get an education which is eons far from getting an answer to a question, it is learning how to *give* answers to a very diverse set of questions, so GO home ChatGPT, you are not a teacher!

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Matteo Paloni @betterwithchem.bsky.social · 15/10/2025

New preprint by @lavagnae.bsky.social from Barducci lab (@cbsmontpellier.bsky.social): we show how energy-consuming enzymatic reactions, like phosphorylation, regulate biomolecular condensates with complex effects on condensate stability and reactive interfaces. Any feedback welcome!

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Carl Zimmer @carlzimmer.com · 09/10/2025

Today my @nytimes.com colleagues and I are launching a new series called Lost Science. We interview US scientists who can no longer discover something new about our world, thanks to this year‘s cuts. Here is my first interview with a scientist who studied bees and fires. Gift link: nyti.ms/3IWXbiE

nyti.ms

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Giulio Tesei @giuliotesei.bsky.social · 02/10/2025

I'm hiring for a PhD position at Malmö University, Sweden! The project will focus on molecular modelling of proteins, lipids, and biomolecular condensates at cell membranes. More details and application form: tinyurl.com/4zm92365 Please feel free to share! @vetenskapsradet.bsky.social | @mau.se

Snapshot of a condensate near a lipid membrane with Swedish Research Council and Malmö University logos.

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Karl Jacoby @karl-jacoby.bsky.social · 26/09/2025

Only an administration intent on committing war crimes in the present and future would stoop to calling Wounded Knee a "battle" rather than what it truly was: a massacre of over 250 Lakotas, mainly women, children, and the elderly. 1/

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Max Planck Institute for the Physics of Complex Systems @mpipks.bsky.social · 19/09/2025

IG Nobel Prize in #Physics 2025 to @mpipks.bsky.social researchers for elucidating the phase behaviour of cacio e pepe sauce. The work highlights how physics can also be applied to solve daily-life problems! nature.com/articles/d41586-025-03045-0

nature.com

Tipsy bats and perfect pasta: Ig Nobels celebrate ‘improbable’ research

The annual awards are a celebration of weird but thought-provoking science.

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Center for Structural Biology (CBS Montpellier) @cbsmontpellier.bsky.social · 20/09/2025

Lancement ce jour du projet d'extension de notre laboratoire. 1100m² de nouveaux espaces et 280m² rehabilités. Merci pour leur soutien à nos tutelles et nos partenaires. @inserm.fr @cnrs.fr @umontpellier.bsky.social @occitanie.bsky.social @villedemontpellier.bsky.social & l'Etat

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Drew Harwell @drewharwell.com · 18/09/2025

The Kimmel video: "The MAGA gang desperately trying to characterize this kid who murdered Charlie Kirk as anything other than one of them, and doing everything they can to score political points from it."

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Mathieu M.J.E. Rebeaud @chercheurjuteux.com · 16/09/2025

Fascisme: encore un exemple. Faire disparaître tout ce qui contredit le Führer Trump.

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Mathieu M.J.E. Rebeaud @chercheurjuteux.com · 15/09/2025

C'est bon là vous avez vu les signes du fascisme ou c'est toujours pas assez...

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David Emmett @motomatters.com · 13/09/2025

This ChatGPT prompt could have been a Bash script

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Ed Zitron @edzitron.com · 05/09/2025

At the heart of gen AI sits a massive economic problem: LLMs are too expensive to charge a monthly fee for, and that is what every single LLM company charges. This will never work. www.wheresyoured.at/why-everybody-is-losing-money-on-ai/#what-if-it-isnt-possible-to-make-a-profitable-ai-company

Generative AI does not fit the classic software pricing model

One of the classic booster arguments is that we're in the "growth stage" of generative AI, where companies "charge a lower price to get people through the door" before cranking up prices, the so-called "profit-lever" that every lazy journalist claims exist for any product economics they don't want to think about too hard.

The problem, I'm afraid, is that generative AI does not match the traditional pricing model for software, which is predominantly sold at a monthly flat price per month.

In traditional software, a "user" generally doesn't cost the developer that much money. One of the big benefits of selling software at scale is that the costs don't scale with you. A web-based application may have an associated cost, but they run on significantly cheaper and widely-available servers, with operations run across less-demanding CPUs, beefier versions of the ones you'd find in your laptop or desktop computer.

Let me get specific. Microsoft Office 365 — one of Microsoft's most profitable business units — for the most part uses CPU-based architectures for its compute, as a Word user, even using Microsoft's cloud-based apps, doesn't require a massive amount of power, because they’re effectively running cloud-based versions of consumer apps. The same goes for things like Google Workspace. Google makes billions of dollars selling access to software that effectively prints money, because the infrastructural burden is mostly "can I make sure this service is available all the time" rather than "do I have the specialized hardware to do so." Its costs — even with power users — are relatively standardized.

Large Language Models are an entirely different beast for several reasons, chief of which are that very few models actually exist on a single GPU, with instances "sharded" across multiple GPUs (such as eight H100s).

Large Language Models require NVIDIA GPUs, meaning that any infrastructure provider must build specialized servers full of them to provide access to said model reliably regardless of a user's location.
A Large Language Model user's infrastructural burden varies wildly between users and use cases. While somebody asking ChatGPT to summarize an email might not be much of a burden, somebody asking ChatGPT to review hundreds of pages of documents at once — a core feature of basically any $20-a-month subscription — could eat up eight GPUs at once.
To be very clear, a user that pays $20-a-month could run multiple queries like this a month, and there's no real way to stop them.
Unlike most software products, any errors in producing an output from a Large Language Model have a significant opportunity cost. When a user doesn't like an output, or the model gets something wrong, or the user realizes they forgot something, the model must make further generations, and even with caching (which Anthropic has added a toll to), there's a definitive cost attached to any mistake.
Large Language Models, for the most part, lack definitive use cases, meaning that every user is (even with an idea of what they want to do) experimenting with every input and output. In doing so, they create the opportunity to burn more tokens, which in turn creates an infrastructural burn on GPUs, which cost a lot of money to run.
The more specific the output, the more opportunities there are for monstrous token burn, and I'm specifically thinking about coding with Large Language Models. The token-heavy nature of generating code means that any mistakes, suboptimal generations or straight-up errors will guarantee further token burn.
Take a look at r/Cursor or a…

This is the core problem of "hallucinations" within any Large Language Model. While many (correctly) dislike LLMs for their propensity to authoritatively state things that aren't true, the real hallucination problem is models subtly misunderstanding what a user wants, then subtly misunderstanding how to do it. As the complexity of a request increases, so too do the opportunities for these subtle mistakes, a problem that only compounds with the use of the reasoning models that are a requirement to make any coding LLM function (as they hallucinate more).

Every little "mistake" creates the opportunity for errors, which in turn creates the opportunity for the model to waste tokens generating something the user doesn't want or that will require the user to prompt the model again. And because LLMs do not have "thoughts" and are not capable of learning, there is no way for them to catch these errors.

In simpler terms, it's impossible to guarantee that a model will do anything specific, and any failure of a model to provide exactly what a user wants all but guarantees the user will ask the model to burn more tokens.

While this might be something you can mitigate when charging users based on their actual token consumption, most generative AI companies are charging users by the month, and the majority of OpenAI's revenue comes from selling monthly subscriptions. While one can rate limit a user, these limits are hard to establish in a way that actually mitigates how much a user can burn.

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Stefano Zanero @raistolo.bsky.social · 05/09/2025

“Is AI good for teaching? Let’s ask an entrepreneur whose entire business is based on that, instead of actual experts”

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Konstantin Roeder @koroeder.bsky.social · 28/08/2025

#Postdoc opportunity to join my group at KCL to work on RNA modelling for 2 years (+1 year pot. extension). #CompChem #ChemPostDoc #PostDocJobs #RNA Apply by 17th September! www.kcl.ac.uk/jobs/123725-...

kcl.ac.uk

Research Associate in Molecular Modelling of RNAs

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Samrat Mukhopadhyay @samratmukhopadhyay.bsky.social · 20/08/2025

Happy to share our community note published in Nature Communications @natcomms.nature.com. In this 14-page article (34 authors from 9 countries), we discuss current practices in phase separation. We hope it will be useful to the biomolecular condensate community. www.nature.com/articles/s41...

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Kresten Lindorff-Larsen @lindorfflarsen.bsky.social · 08/08/2025

If you want to learn about AWSEM, CALVADOS, Mpipi or FINCHES, I am not sure this is the best paper to read But, hey, at least I learnt about a paper we apparently wrote in 2014 (ref 80) FINCHES: A Computational Framework for Predicting Intermolecular Interactions in IDPs doi.org/10.3390/ijms...

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Mathieu M.J.E. Rebeaud @chercheurjuteux.com · 08/08/2025

Jpp des sorties à la con de *Ph.D level expert* pour les IA. Si il était niveau Ph.D, il regretterait ses choix, voudrait ouvrir un café sur les Alpes ou devenir éleveur de chèvres et ne jamais revivre ça et la santé mentale qui va avec le Ph.D. (bon j'aime ce que je fais hein, blague).

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Derek Lowe @dereklowe.bsky.social · 04/08/2025

New computational methods conjure up ligands for the famously difficult class of disordered proteins - but how far can they go?

science.org

Disordered Proteins Brought Into Line

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il Post @ilpost.it · 17/07/2025

Secondo il ministro della Giustizia il sovraffollamento nelle carceri non è connesso ai suicidi, anzi, contribuirebbe a sventarli. Non è vero. ilpost.link/BIROoWOk2u

ilpost.link

Secondo Nordio il sovraffollamento nelle carceri ha fatto anche cose buone - Il Post

In un'intervista al Corriere il ministro della Giustizia ha detto che non è connesso ai suicidi, anzi, contribuirebbe a sventarli: non è così

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SpruijtLab @spruijtlab.bsky.social · 16/07/2025

New in JACS! Using NMR, we show how condensates selectively bind and localize ions following the 'law of matching water affinities', shaping condensate composition, interface potential & RNA stability. Read about it here: doi.org/10.1021/jacs.5c07295 @irissmokers.bsky.social

doi.org

Selective Ion Binding and Uptake Shape the Microenvironment of Biomolecular Condensates

Biomolecular condensates modulate various ion-dependent cellular processes and can regulate subcellular ion distributions by selective uptake of ions. To understand these processes, it is essential to...

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