Professor Tung Le, John Innes Centre – contact me Professor Jonathan Todd, Quadram Institute & UEA Dr Ngat Tran, John Innes Centre Horizontal gene transfer (HGT) is a major driver of bacterial…

Bacterial spores are among the most durable of cell forms, protected by robust envelopes of layered protein assemblies. Remarkably, these envelopes often share similar architectures across distantly r...

Download this free 3D print file designed by CiliaBuilder. EM Grid Scaled ModelScaled up and simplified 3D model of EM grids and autogrids for demonstration of preparation process and milling. Content...

From individual proteins and complexes to cells and organs, science relies on us being able to visualise what can't be seen with the naked eye. Find out ho…

Scientists have mapped in unprecedented detail the structure of Vibrio bacteria, which can cause life-threatening infections linked to antibiotic resistance.

Most bacteria use a flagellum, to swim and disseminate in their environment, and it is essential for virulence. In Vibrio, the flagellum is surrounded by a sheath, a membrane-like shield that protects...

The bacterial flagellum is a large proteinaceous macromolecular machine that enables motility, host interaction, and virulence across bacterial specie…

Investigating the Tad pilus nanomachine in a genetically tractable, non-pathogenic organism like Caulobacter crescentus provides a powerful model for elucidating the architecture and functional dynamics of this widespread system. Insights gained from studying the Tad machinery can improve our understanding of related Tad pilus systems in pathogenic bacteria such as Aggregatibacter actinomycetemcomitans, where Tad pili are a key determinant of biofilm formation and chronic infection. Additionally, the remarkable functional diversity of Tad systems, ranging from surface sensing in C. crescentus to bacterial predation in Myxococcus xanthus, highlights their broad biological relevance. By revealing the in situ architecture of the Tad pilus biosynthetic machinery, this study advances our understanding of a major class of bacterial nanomachines and may thus provide structural insights that could inform the development of new therapeutic strategies targeting pilus-mediated virulence.

Can you find the Euler angles of a cryo-EM projection?

In several pathogenic bacteria, including Vibriospecies, the filament of the bacterial flagellum is encased by a membranous sheath, an extension of the bacterial outer membrane. It has been proposed t...

King's College London spin-out company Prosemble, co-founded by Dr Julien Bergeron, has been awarded Innovate UK funding as part of the Biomedical Catalyst to transform cancer care with cutting-edge n...

The Tad pilus is involved in the formation of antibiotic-resistant biofilms in many bacteria, including the human pathogen Pseudomonas aeruginosa. The authors report the structure of the Tad pilus pro...

Scientists have studied a new target for antibiotics in the greatest detail yet – in the fight against antibiotic resistance.

Cryo-electron microscopy analysis of the extracellular flagellum structure, including the hook–filament junction and filament cap complex, reveals mechanisms of flagellin incorporation into the growin...

Scientists have studied a new target for antibiotics in the greatest detail yet – in the fight against antibiotic resistance.

Cryo-electron microscopy analysis of the extracellular flagellum structure, including the hook–filament junction and filament cap complex, reveals mechanisms of flagellin incorporation into the growin...

The cytoskeleton is crucial for cell organization and movement. In Eukaryotes, it largely consists of the protein actin, that forms a double-strand...

The Great Wall Symposium will take place from 18th to 20th September 2023 at the venue in The Vila Galé Sintra Hotel, in Portugal.

PhD Project - PhD studentship: Structural and functional characterisation of mycobacterial outer membrane proteins at Newcastle University, listed on FindAPhD.com