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An evolutionary model of clonal hematopoiesis (CH) describes the genetic changes of HSCs through life, predicts the ubiquity of polyclonal competition, and identifies multistage CH progression with va...

Over the course of a lifetime, somatic mutations accrue in normal human cells, causing variation in cell phenotype and engendering somatic evolution with outcomes ranging from the adaptive immune syst...

UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).

Seasonal respiratory infections typically surge within a limited time window, but what determines the exact timing within a given year is not well understood. Major causes of death show a similar seas...

Nigel Farage has announced his resignation as the MP for Clacton, triggering a byelection in which he intends to stand as a candidate. The Reform UK leader is under scrutiny over his finances, with tw...

Longitudinal transcriptomic, chromatin and genomic analyses of the two types of IDH-mutant glioma reveal in detail how disease progression is influenced by interdependent genetic, epigenetic and micro...

Researchers have developed a new way to understand how genetic changes linked to blood cancer evolve in our cells, offering new insight into predicting blood cancer risk.

Abstract. Clonal hematopoiesis (CH) — the expansion of genetic variants in blood — is a prime example of somatic evolution. Although it often precedes malignant transformation, many aspects of this pr...

DNA-sequencing data from primary tumours and paired metastases from participants in the TRACERx lung study and PEACE autopsy programme are used to analyse the metastatic diversity of advanced non-smal...

Proposal said to be contained in internal Pentagon email is thought to be bid to punish European countries for failing to assist in war in Iran

When oncogenic genetic elements untether from chromosomes and no longer follow Mendelian inheritance, genomic chaos and accelerated evolution ensues. In this review, Wong et al. discuss the mechanisti...