This Special Communication introduces the updated Consolidated Standards of Reporting Trials (CONSORT) 2025 statement, which includes substantive and structural changes to account for recent methodolo...

The PPI for Statisticians Community of Practice (CoP) aims to bring together statisticians who are interested in patient and public involvement to share experiences for others to learn from, share res...

The story of a crime scene investigation through the eyes of forensic scientists.

A guest post by Dr Anne Toomey, author of the book "Science with Impact: How to Engage People, Change Practice, and Influence Policy".

A guest post by Dr Anne Toomey, author of the book "Science with Impact: How to Engage People, Change Practice, and Influence Policy".

Healthcare accounts for 4% of the overall greenhouse gas emissions worldwide. Reducing carbon emissions is a key strategic aim for health systems in multiple countries. To achieve this, environmental ...

Healthcare accounts for 4% of the overall greenhouse gas emissions worldwide. Reducing carbon emissions is a key strategic aim for health systems in multiple countries. To achieve this, environmental ...

Routinely collected data (RCD) from healthcare claims and encounters are increasingly used for outcomes in randomized trials; however, methods for estimating the validity and relative precision of RCD...

This article presents the CONSORT (consolidated standards of reporting trials) extension for cluster randomised crossover trials. A cluster randomised crossover trial involves randomisation of groups ...

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The following review has been prepared by members of the MRC-NIHR Trials Methodology Research Partnership. The reviewers are all qualified statisticians with experience in clinical trials. Our objecti...

ObjectivesTo review and synthesise available evidence on carbon emissions associated with clinical trials to inform future research on design and delivery of gr

Background Clinical trials aim to draw conclusions about the effects of treatments, but a trial can address many different potential questions. For example, does the treatment work well for patients w...

When the primary outcome of a clinical trial fails to reach its prespecified end point, can any clinically meaningful information still be derived from it? This review article addresses that question.

When is it legitimate to exclude randomised patients from the analysis of data in clinical trials? Basing their analysis on the desirability of minimising bias and random error, the authors consider t...

Background: For RCTs with time-to-event endpoints, proportional hazard (PH) models are typically used to estimate treatment effects and logrank tests are commonly used for hypothesis testing. There is...

YouTube video by INI Seminar Room 1