iiinova — where your digital self keeps evolving

Karl Herrup @asparatics.bsky.social · 02/09/2026

I just downloaded MapQuest and deleted both GoogleMaps and AppleMaps. Lake America??!! Such industrial grade BS from two cowardly companies.

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Karl Herrup @asparatics.bsky.social · 22/08/2026

As others have said, what the Sam Hill is “conservative based research”. Why not reality based?

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Karl Herrup @asparatics.bsky.social · 15/08/2026

“So the very origins of representation in our historical tradition are really about taxation, … when rulers want to tax, they become dependent on the taxpayers. And it builds a connection between the ruler and the ruled, and it gives the taxpayers power.” substack.com/app-link/pos...

substack.com

Vanessa Williamson on Taxes and Democracy

What tax history teaches us about this dire moment

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Karl Herrup @asparatics.bsky.social · 15/08/2026

Just when you thought things couldn’t get any worse …

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Sachin Gadani @saching.bsky.social · 30/07/2026

The Gadani Lab at the University of Pittsburgh is recruiting a post-doc! We are a new neuroimmunology lab interested in progressive multiple sclerosis, meningeal inflammation, and reactive glia. We are looking for a PhD scientist to spearhead funded research on Treg–glia interactions.

cfopitt.taleo.net

Post Doctoral.Post Doctoral.Associate

Click the link provided to see the complete job description.

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Karl Herrup @asparatics.bsky.social · 24/07/2026

Biggest news out of the AAIC meeting? We can celebrate even modest successes, but here the caveats vastly outweigh them: small effect size; weird results at highest doses; still only Phase II. Maybe keep your champagne on ice, but don't pop any corks yet. www.science.org/content/arti...

science.org

Alzheimer’s trial results lend momentum to strategies targeting tau

First drug to lower the protein and slow cognitive decline creates buzz despite puzzling data

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Karl Herrup @asparatics.bsky.social · 15/07/2026

Same data, different perspective. We have many “clocks” in our bodies, but I can’t escape the sense that all of them keep ticking no matter who we are or how we live our lives. Live well, but accept your mortality.

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Karl Herrup @asparatics.bsky.social · 15/07/2026

www.nature.com/articles/s41... Just finished this excellent review by @erictopol.bsky.social and Wyss-Coray. The authors emphasize how discordant the aging of each organ is, but I am struck instead by how similar the time lines are.

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Karl Herrup @asparatics.bsky.social · 11/07/2026

I finally commented on the proposed OMB rule change (through the #StandUpForScience portal). I emphasized the economic and security damage that will be done. I figured the damage to science will be well covered by others. Doubt that anyone in power will read it, but I know I did the right thing

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Karl Herrup @asparatics.bsky.social · 10/07/2026

In fact, let this be a first public announcement: I am about half done writing a second book. Finishing that project will certainly keep this Professor Emeritus busy for the foreseeable future. It's a follow on, but not a sequel to Book #1. Working title: "Aging sucks: a love story" Stay tuned

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Karl Herrup @asparatics.bsky.social · 10/07/2026

I only have one Bluesky account so I mix science and politics. I read politics, but try to only post science (a blurry dividing line these days). Today, science news: as of July 1st I am officially Professor Emeritus. It's been a great run. But don't worry; I'm not done commenting or writing.

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Dr. SkySkull @drskyskull.bsky.social · 03/07/2026

This is the thing that so many Americans don’t seem to grasp: private companies are in it to make a profit, and nothing else. There are so many important, necessary discoveries that industry will never look into simply because they can’t make enough money on it.

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Karl Herrup @asparatics.bsky.social · 15/06/2026

I’m not ashamed to admit that about half way through I had to reach for my handkerchief. And looking around, I was not alone. I want my country back!!

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Karl Herrup @asparatics.bsky.social · 15/06/2026

Pittsburgh symphony did a powerful All-American concert yesterday, ending with Copland’s 1942 “Lincoln Portrait”. The words were Lincoln’s, but the resonance of their message with today was almost unbearable. Especially coming on the day of the abomination on the South Lawn of the White House.

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Karl Herrup @asparatics.bsky.social · 20/05/2026

I’m from Pennsylvania and I am deeply embarrassed by this vote from the “democratic” senator I voted for. Please know I will work very hard to make sure he never holds elective office again … not even mayor of Braddock.

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Karl Herrup @asparatics.bsky.social · 13/05/2026

I understand your positive attitude, I just have a bad attitude towards the current amyloid/tau disease models. The biomarkers and concepts like “preclinical AD” make sense only if our models are correct. There is plenty of evidence out there that they are not. (I wrote a whole book on this)

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Citizen X @mayoubhappy.bsky.social · 29/04/2026

This👇🏽 deserves to be posted 100 times but I’d be labeled spam.

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Karl Herrup @asparatics.bsky.social · 28/04/2026

And I am a Majority Inspector for my Ward in Allegheny county. This is truth. There is nothing even remotely suspicious. No fraud. No hanky-panky. No illegal voting. Just a tightly organized system to conduct free and fair elections. Now. GO VOTE!

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Jenna Norton @jenna-m-norton.bsky.social · 25/04/2026

NAS President Marcia McNutt claims she is being bipartisan by avoiding “topics for which there is a partisan divide.” But this is blatantly partisan. She is doing exactly what one party wants. Worse, in direct opposition to the science in these fields. 🧵1/?

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Jeff Browndyke @jeffbrowndyke.bsky.social · 25/04/2026

...the infusion therapies DO NOT reverse the Alzheimer's disease dementia process in those already showing even mild symptoms (i.e., all the people currently being direct marketed to like gangbusters on TV and online). www.cochrane.org/about-us/new... 3/n

cochrane.org

Anti-amyloid Alzheimer’s drugs show no clinically meaningful effect | Cochrane

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Karl Herrup @asparatics.bsky.social · 25/04/2026

It’s worse than that. The new therapies are half as effective as safe cholinesterase inhibitors and cost 100 times more. The companies won’t release their data so true estimates of risk are hard to know. The blitz of TV ads are essential to them because this is marketing not medicine.

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sam³⁰⁰⁰ @samgavin.com · 29/03/2026

A remarkable photo from #NoKings in DTLA from Connor Sheets of @latimes.com www.latimes.com/california/l...

LAPD officers arrest a protester dressed as the Statue of Liberty outside a federal building during a ‘Kings Day’ protest. (Connor Sheets/Los Angeles Times)

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Karl Herrup @asparatics.bsky.social · 18/03/2026

Stay strong. You’re our future.

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Karl Herrup @asparatics.bsky.social · 10/03/2026

Her work resonates so well with your commentaries on that period of your own life that I think you two would have much to talk about. You can reply yes or no or contact her directly at gotos@nagasaki-u.ac.jp. We work together on Japanese gardens and Alzheimer’s disease, but that’s another story

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Karl Herrup @asparatics.bsky.social · 10/03/2026

@georgetakei.bsky.social I write to connect you with a colleague of mine. Her name is Seiko Goto, a Professor of landscape architecture at Nagasaki University and currently working on the history of the Manzanar internment camp and the formal Japanese gardens the inmates were able to build.

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Karl Herrup @asparatics.bsky.social · 10/03/2026

Or you could join a public library and pay $0.

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Karl Herrup @asparatics.bsky.social · 03/02/2026

They always leave out simple science words: actin, exon, intron. These are important (and common) cell and molecular structures

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Russ @pappyparki.bsky.social · 27/01/2026

Senator John Fetterman D-PA continues to support the kidnapping, robbery, rape & murder of his wife & his own voters. Like many if his Republican colleagues it turns out that being married to an immigrant, legal, undocumented or anchor baby is simply cover. Their wives are their "black friend"

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Dr Kathleen Millen @neurodevkathy.bsky.social · 26/01/2026

Current NIH + HHS staff signed a letter calling for Senators to block the DHS/ICE/HHS bill even though they will not be paid if gov't shuts down. I'm a NIH funded scientist with grants on the line this round. I support them! Blocking DHS is more important right now! www.savehhs.org/stop-ice-pro...

savehhs.org

Save HHS | Support Public Health – Take Action Now

Save HHS is a collaboration among the National Public Health Coalition, 27 UNIHTED, and countless current and former HHS staff. Join us in calling for public health as a vital government service. The ...

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Karl Herrup @asparatics.bsky.social · 16/01/2026

Our universities are failing us.

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Dr Kathleen Millen @neurodevkathy.bsky.social · 02/01/2026

I don't think you non-science people realize what it takes to get a grant funded by NIH. Started experiments in Sept 2021 to generate 3 new mouse mutants to model human disease. Prelim dara shows they have relevant disease phenotypes worthy of study. Need a small grant first to characterize /1

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Karl Herrup @asparatics.bsky.social · 16/11/2025

For those who follow me for politics and wonder what I’m yammering about, let me explain. I’ve got this day job as a scientist. I’m in San Diego at the annual Soc. for Neuroscience meeting. Today was our poster on DNA damage and Alzheimer’s disease. It got assigned to a silly location in the hall.

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Karl Herrup @asparatics.bsky.social · 16/11/2025

Note to Program Committee: moved the poster from RR7 to D40. I know. I know. Patently illegal. But it was an empty board even 90 minutes into the morning. So no harm. Within minutes, traffic increased 10x (and I must say, it was really well received). Thanks to all who dropped by.

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Karl Herrup @asparatics.bsky.social · 16/11/2025

Program committee put our Alzheimer poster in the ultrasound group. OK we have some MEA data, but still. Come see a lovely APP DNA damage story. You won’t regret the trek to RR

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Karl Herrup @asparatics.bsky.social · 10/11/2025

One more thought. Voters will be pissed, but that will likely be short term. My real fear is that millions will decide that their party isn’t fighting for them, so they will give up and stay home in ‘26, just like they did in ‘24.

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Karl Herrup @asparatics.bsky.social · 10/11/2025

I see your point. It’s just that Democrats have never had the leverage they have right now, and they are about to lose it. Yes, it’s the responsible thing to do in normal times, but Republicans are not responsible people and these are not normal times. Millions of dem voters will be royally pissed

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Karl Herrup @asparatics.bsky.social · 10/11/2025

I never imagined you would be on the wrong side of an issue of this importance.

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Charles F. Caskey @cfcaskey.bsky.social · 18/08/2025

Planning to resubmit something sitting at 9%. Makes me want to look for another job.

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Karl Herrup @asparatics.bsky.social · 29/07/2025

We missed our chance at Pitt. But we wish you all the best with our friends in CBN. Check out The Frog and The Peach first chance you get.

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Karl Herrup @asparatics.bsky.social · 05/07/2025

I’ve never been able to catch your AMA sessions. I only read (& love) them. But I woke up this Saturday morning with a haunting question for you. In the not too distant future, when the last immigrant is jailed or deported, what will all those ICE personnel do to pass the time of day? Stay strong.

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