Researchers at the University of Rome show how epithelial-mesenchymal transition influences lipotoxic responses in colorectal cancer cells.

Neurons in the aging brain experience sustained inflammatory, proteostatic, and genotoxic stress, accompanied by the accumulation of non-canonical nucleic acid structures such as G-quadruplexes (G4s)....

Editors recognize the heavy-lifters and rising stars during Peer Review Week.

Cyanobacteria, evolutionarily ancient photoautotrophs, serve as key model organisms for studying diverse biological processes. Lysine butyrylation (Kbu) is an emerging post-translational modification ...

A targeted lipidomics study finds that the anti-inflammatory oxylipin cargo of HDL is depleted in men and Hispanic adults with mild cognitive impairment, independent of cholesterol levels.

YouTube video by the bumbling biochemist

YouTube video by American Society for Biochemistry and Molecular Biology (ASBMB)

In BriefImmunopeptidomics enables untargeted discovery of peptides presented by MHC molecules, informing vaccine and immunotherapy development. Existing workflows focus either on throughput or sensiti...

In BriefThis study presents the first region-resolved, multi-omic characterization of pituitary neuroendocrine tumors (PitNETs), revealing distinct molecular and microenvironmental features between ca...

Myosins transduce chemical energy into mechanical work, with key steps being the powerstroke and the release of phosphate (Pi) from the active site. This process is still poorly understood, in part, b...

Water (H2O), the principal component of living organisms including humans, dissociates into H+ and OH- in aqueous environments, and the resulting H+ concentration determines both cellular pH and the proton motive force (PMF) across cellular membranes. These physicochemical parameters are fundamental regulators of a wide range of biological processes. Optogenetics enables the manipulation of biological and cellular functions using light, typically through the ectopic expression of microbial rhodopsins as photoreceptive proteins in target cells or organs.

The lipase LipA from Pseudomonas aeruginosa is an extracellular enzyme that plays an important role in bacterial infections. Prior to its export via the type II secretion system, LipA requires the cog...

Proper protein production is an essential biological process for all known living organisms. The cell depends on a functional protein homeostasis, or proteostasis, network to facilitate proper gene ex...

The mitochondrion embeds numerous metabolic, biosynthetic, and signaling pathways occurring within its specialized compartments that collectively define eukaryotic biology. To visualize these, cryogen...

Glucosinolates (GLSs) are sulfur-rich secondary metabolites characteristic of Brassicales and play central roles in plant defense. While the biosynthesis and long-distance allocation of GLSs have been...