DNA modifications are central to carcinogenesis, chemotherapy drug action, neurodegeneration, and aging. Here, we present a protocol for click-code-seq, a next-generation sequencing technique for geno...

Padvitski, Unger Avila, Chen et al. introduce a single-cell transcriptomic framework that quantifies progressive cellular damage across degenerative disease models. Applied to kidney and liver injury,...

Regeneration after spinal cord injury requires progenitor cells to convert injury-associated signals into coordinated remodeling of gene regulatory programs. Mammalian spinal progenitors show limited ...

Genomes can be modelled with language approaches by treating nucleotide bases A, C, G and T like text, but there is no natural concept of what the words would be and whether there is even a ‘language’...

Human DNA replicates according to a precise schedule: certain regions are replicated early, while others replicate later in the cell cycle. The DNA sequence and the epigenome are both indicative for r...

Faithful DNA replication is essential for genome stability, yet replication forks face constant stress. The Bloom syndrome helicase (BLM) safeguards fork integrity, but excessive BLM activity can itse...

Nature Aging - Connecting fragmented aging research through the European Federation for Aging Research

The Bioinformatics Division of the Institute of Biological and Geosciences (IBG-4) processes and develops methods and algorithms to achieve a fundamental understanding of high-dimensional data and pro...

Der Code des Lebens – der Wissenschaftspodcast von GHGA beschäftigt sich mit verschiedenen Aspekten der menschliche Genomforschung. Wie ist unser Erbgut entstanden? Wie funktioniert Genomforschung und...