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ETH Laboratory of Toxicology

@sturlalab.bsky.social
223 followers 16 following 31 posts

Understanding biochemical mechanisms governing bioactive properties of chemicals. Developing novel chemical bioanalysis methods. Advancing precision approaches in disease prevention and therapy. Visit us @ toxicology.ethz.ch

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ETH Laboratory of Toxicology @sturlalab.bsky.social · 01/09/2026
worldfoodsystem.ethz.ch/news/wfsc-ne...
worldfoodsystem.ethz.ch
Gut microbes transform common herbicide into previously unknown compounds
The human microbiome may play a critical role in determining the health impacts of chemical exposure from food, according to new research on the herbicide metazachlor.
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ETH Laboratory of Toxicology @sturlalab.bsky.social · 24/08/2026
🧪 New paper in Environmental Science & Technology ! "Human Gut Microbes Transform the Chloroacetamide Herbicide Metazachlor to Metabolites with Altered Toxicological Characteristics"🦠🌾 doi.org/10.1021/acs.... #Toxicology #Microbiome #EnvironmentalHealth
doi.org
Human Gut Microbes Transform the Chloroacetamide Herbicide Metazachlor to Metabolites with Altered Toxicological Characteristics
Abstract. Metazachlor is a globally relevant chloroacetamide herbicide that undergoes microbial biotransformation in the environment, but its transformatio
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ETH Laboratory of Toxicology @sturlalab.bsky.social · 21/08/2026
Check out the STAR publication: "Click-code-seq protocol for genome-wide single-nucleotide-resolution mapping of major types of DNA modifications" ⭐ www.cell.com/star-protoco... 🧬 Whole #genome instability 💻 #Computational pipeline
cell.com
Click-code-seq protocol for genome-wide single-nucleotide-resolution mapping of major types of DNA modifications
DNA modifications are central to carcinogenesis, chemotherapy drug action, neurodegeneration, and aging. Here, we present a protocol for click-code-seq, a next-generation sequencing technique for geno...
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ETH Laboratory of Toxicology @sturlalab.bsky.social · 21/08/2026
New paper alert !🚨 "Human internal exposures to alternariol and its monomethyl ether are predicted below thresholds of in vitro toxicity by physiologically based kinetic modeling" doi.org/10.1007/s002... 🍄Alternaria #mycotoxins 🔎In vitro hepatic metabolism 👩‍💻Toxicokinetic modeling ☠️ #Riskevalulation
doi.org
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ETH Laboratory of Toxicology @sturlalab.bsky.social · 30/07/2026
#Congrats 🎉 @profshana.bsky.social appointed Fellow of @acs.org, highlighting her pioneering contribution to toxicology research 👏🏻👏🏻👏🏻 ➡️ ethz.ch/staffnet/en/...
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ETH Laboratory of Toxicology @sturlalab.bsky.social · 26/05/2026
Last week, the ARET-SFTG-STCM Colloquium on Perinatal Health & Toxic Environments brought together cutting-edge research at @upjv-univ.bsky.social. Our PhD student Hélène Bigonne took home a best oral presentation award for her talk on toxicokinetics in pediatric populations and female tissues 🏆!
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ETH Laboratory of Toxicology @sturlalab.bsky.social · 26/05/2026
Amazing meeting in Rome for WP5 of #PARC. Our PhD student Blandine Descamps presented a project on the #riskassessment of emerging mycotoxins and received the award! 🌟🏆 This work is in collaboration with @univie.ac.at. #emergingmycotoxins #Alternaria #PBKmodel #riskevaluation
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ETH Laboratory of Toxicology @sturlalab.bsky.social · 26/05/2026
🎉 Exciting news! We're thrilled to announce our latest publication in Microbiota and Host: "Quantitative chemical activity profiling reveals gut microbiome modulations" available at mah.bioscientifica.com/view/journal... #GutMicrobiome #Microbiota #ChemicalBiology #NewPublication #ResearchHighlight
mah.bioscientifica.com
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ETH Laboratory of Toxicology @sturlalab.bsky.social · 01/04/2026
Check out our new paper "UVA Irradiation Promotes ROS-Mediated Formation of the Common Deletion in Mitochondrial DNA" !🧬☀️ ▶️https://www.mdpi.com/2075-1729/16/4/577 Congrats to Gabriele Fontana, Navnit Singh, @profshana.bsky.social and co-authors for this achievement ! @mdpiopenaccess.bsky.social
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ETH Laboratory of Toxicology @sturlalab.bsky.social · 20/03/2026
Check out our new paper ➡️ doi.org/10.1007/s002... ! 🦠Gut microbial metabolism of hop-polyphenols 🔮Integration into PBK modeling 🧫Estrogenicity of iXN, 8-PN, and mixtures Congrats to our team members, Maja Stevanoska🎓, @georgaichinger.bsky.social and @profshana.bsky.social !
doi.org
Interindividual variability in gut microbial formation of the hop phytoestrogen 8-prenylnaringenin results in elevated but sub-toxic internal exposures - Archives of Toxicology
Archives of Toxicology - The gut microbiome converts the prenylated polyphenol isoxanthohumol (iXN), a natural constituent of hops found in beer, into 8-prenylnaringenin (8-PN), a potent...
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ETH Laboratory of Toxicology @sturlalab.bsky.social · 21/11/2025
PhD position alert 📢📢📢 🦠 Emerging mycotoxins - human gut microbiota - molecular mecanisms 🏢 University of Vienna, Institute of Food Chemistry and Toxicology 💌 francesco.crudo@univie.ac.at #microbiome #PhDPosition #toxicity #science #career #AcademicJobs
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ETH Laboratory of Toxicology @sturlalab.bsky.social · 21/11/2025
Congratulations to Emile Aghajani for her poster "Developing mechanistic and responsive biomarkers of aging based on genome-wide maps of DNA breaks and oxidation" receiving award at #SST2025 ! ✨ @vakil-takhaveev.bsky.social @profshana.bsky.social
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ETH Laboratory of Toxicology @sturlalab.bsky.social · 21/11/2025
#SST2025 presenters from the laboratory of toxicology (3/3): Navnit Singh - 🧬🧪💥 Alona Slastennikova - 🌱💩🦠 Maja Stevanoska - 💩🦠📉
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ETH Laboratory of Toxicology @sturlalab.bsky.social · 21/11/2025
#SST2025 presenters from the laboratory of toxicology (1/3): Emilie Aghajani - ⌛👵🧬 Hélène Bigonne - ♀️💻♂️ Blandine Descamps - 🍄🧫💻 Raúl Fernández Cereijo - 💻🦠📈
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ETH Laboratory of Toxicology @sturlalab.bsky.social · 21/11/2025
#SST2025 presenters from the laboratory of toxicology (2/3): Dr. Jacob Folz - 🦠💩🧪 Jasmin Huber - 🧬✂️👩‍🔬 Lucie Lefevre - 🧬💻📈 Livia Pietrow - 🧠🧬👵
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ETH Laboratory of Toxicology @sturlalab.bsky.social · 21/11/2025
Huge turnout from our Toxicology Lab at yesterday’s SST meeting. Proud of the team and happy to share our work 💖 Special thanks to the organizers @profshana.bsky.social , Gina Montoya Parra and Laura Suter-Dick ! #SST2025
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ETH Laboratory of Toxicology @sturlalab.bsky.social · 04/11/2025
PhD position alert 📢📢📢 🦠 Impact of microbiome biotransformation on chemical toxicity 🏢 ETH Zürich, Laboratory of toxicology 🧑‍🔬 @georgaichinger.bsky.social & @profshana.bsky.social jobs.ethz.ch/job/view/JOP... #NAMs #microbiome #bioinformatics #PhDPosition #toxicity #science #career #AcademicJobs
jobs.ethz.ch
PhD Position in Toxicology
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Reposted by ETH Laboratory of Toxicology
Vakil Takhaveev @vakil-takhaveev.bsky.social · 02/11/2025
New publication alert! Click-code-seq, our DNA-damage sequencing method, is now out! This tool can advance our understanding of aging, cancer and neurodegeneration. Huge thanks to the amazing collaborative team behind this! @sturlalab.bsky.social @ethz.ch
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ETH Laboratory of Toxicology @sturlalab.bsky.social · 29/10/2025
@georgaichinger.bsky.social & @profshana.bsky.social presented at #ICT2025 in Beijing! 🌏 KL “Advancing Chemical Research in Toxicology: From Genotoxicity to Gut Microbial Metabolism” “Quantifying the Gut Microbiome’s Impact on Toxicokinetics by PBK Modeling.” #IUTOX2025 @nynkekramer.bsky.social
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ETH Laboratory of Toxicology @sturlalab.bsky.social · 17/10/2025
Exciting contribution from our lab at the 8th EU–US Conference on Endogenous DNA Damage and Repair! 🔬🌍 Dr. Vakil Takhaveev (@vakil-takhaveev.bsky.social) presented a great showcase of how innovative sequencing approaches advance our understanding of genome integrity. 💡🧬
Click-code-seq reveals how transcription, epigenetics, and aging shape DNA damage in the human genome.
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ETH Laboratory of Toxicology @sturlalab.bsky.social · 08/10/2025
Great reception to our work in India! 🙌🏽 Shana Sturla presented our research “Mapping chemical modifications throughout the human genome” at the Global Scientific Conference 2025, VMCC IIT Bombay, bringing global experts together to turn discovery into impact. 🌍🔬
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ETH Laboratory of Toxicology @sturlalab.bsky.social · 07/10/2025
If you need information on carcinogenic alkylating agents, check out this amazing new book chapter! 📘✨ Authors: Jasmin Huber, Monika Kojic, Claudia Aloisi, and Shana Sturla 👉 doi.org/10.1016/B978... Congrats to all authors for this outstanding contribution to the field of molecular toxicology! 👏🧬
doi.org
Redirecting
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ETH Laboratory of Toxicology @sturlalab.bsky.social · 07/10/2025
🎓 Big congrats to our MSc student Emanuel Schönbächler for successfully defending his thesis: “Expanding Click-Code-Sequencing for Mapping Oxidative and Alkylation DNA Modifications.” 💥🧬
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Reposted by ETH Laboratory of Toxicology
Georg Aichinger @georgaichinger.bsky.social · 26/09/2025
It's finally published in ES&T: We developed a PBK model for BPA analogues with a multimodal parameterization approach. 👉 yes we can! (predict biokinetics without in vivo data) 👉 analogues reach much higher internal concentrations than BPA #toxicology #plastics #EDCs pubs.acs.org/doi/10.1021/...
pubs.acs.org
Human Internal Exposures of Bisphenol A and Six Data-Poor Analogs Predicted by Physiologically Based Kinetic Models with Multimodal Parametrization
Bisphenols (BP) AF, B, E, F, M, and S are increasingly used as bisphenol A (BPA) substitutes. Despite widespread exposure and potential adverse health outcomes, they are poorly understood in terms of ...
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ETH Laboratory of Toxicology @sturlalab.bsky.social · 18/09/2025
PhD student Emilie Aghajani and Dr. @vakil-takhaveev.bsky.social represented us at #ARDD2025 in Copenhagen, sharing their work on developing mechanistic biomarkers of aging through genome-wide DNA damage mapping. A fantastic opportunity to connect with the aging research community!
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ETH Laboratory of Toxicology @sturlalab.bsky.social · 18/09/2025
Our fantastic postdoc Vakil Takhaveev (@vakil-takhaveev.bsky.social) rocked the EFMC Young Medicinal Chemists’ Symposium in Porto 🇵🇹 @euromedchem.bsky.social, presenting how DNA-damage sequencing can reveal anti-cancer drug mechanisms and push precision oncology forward! ✨🧬
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ETH Laboratory of Toxicology @sturlalab.bsky.social · 18/09/2025
🌍 Our team had the privilege to showcase our latest advances in developing #NAMs under the equator at #WC13! ✨ 🔬 @georgaichinger.bsky.social – microbiome-competent biokinetic modeling 🧪 Blandine Descamps – prediction of emerging mycotoxins toxicokinetics ⚖️ Hélène Bigonne – sex-informed PBK models
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ETH Laboratory of Toxicology @sturlalab.bsky.social · 11/09/2025
✨ Our lab members Nina Frei, Jasmin Huber, and Lucie Lefevre had an inspiring day at the SCS Fall Meeting 2025 @swisschemistry.bsky.social in Zürich! It was a fantastic opportunity to exchange ideas, discover cutting-edge research, and connect with the vibrant Swiss chemistry community. 🌍🔬💡
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ETH Laboratory of Toxicology @sturlalab.bsky.social · 11/09/2025
Great discussions at the #Metabolomics2025 in Prague ! ✨ Our brilliant postdoc Jacob Folz presented his research on "Quantifying rate and global profile of gut microbiota metabolism ex vivo by LC-MS/MS". 🦠 Stay tuned - his new publication is on the way ! 😉
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ETH Laboratory of Toxicology @sturlalab.bsky.social · 21/11/2024
Quite a day at the Annual Meeting of the Swiss Society of Toxicology with talks by @georgaichinger.bsky.social (microbiome-competent PK modeling) & @vakil-takhaveev.bsky.social (DNA damage sequencing). Special Congrats to PhDs Alona Slastennikova and Blandine Descamps who received poster awards!💪🥳
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