iiinova — where your digital self keeps evolving

Andrew DeSio BBBBCCCCCCCIDPPPPS @andrewdesio.bsky.social · 30/09/2026

Let’s talk complicated UTIs due to ESBL! See you over on YouTube! Gram Negative Guidance ESBL Complicated UTIs youtube.com/shorts/jxXWe... via @YouTube

youtube.com

Gram Negative Guidance ESBL Complicated UTIs

YouTube video by KetamineRx

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Andrew DeSio BBBBCCCCCCCIDPPPPS @andrewdesio.bsky.social · 29/09/2026

Still Using the Bazett Formula? YOU CAN’T SIT WITH US! Correct the qtc with a better formula today! youtube.com/shorts/lNDuc... via @YouTube

youtube.com

Still Using the Bazett Formula? YOU CAN’T SIT WITH US!

YouTube video by KetamineRx

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Andrew DeSio BBBBCCCCCCCIDPPPPS @andrewdesio.bsky.social · 28/09/2026

Can’t invest an hour into learning the gram negative guidance? Hop in for some quick highlights, this time about uncomplicated UTIs due to ESBL! IDSA Gram Negative Guidance - ESBL uncomplicated UTIs youtube.com/shorts/hz_Cz... via @YouTube

youtube.com

IDSA Gram Negative Guidance - ESBL uncomplicated UTIs

YouTube video by KetamineRx

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Reposted by Andrew DeSio BBBBCCCCCCCIDPPPPS

The BMJ @bmj.com · 17/09/2026

How do people pursuing assisted suicide in Switzerland report the motivations underpinning their decision? New BMJ Research finds people describe the decision not only as a response to suffering, but also as a deliberate way of shaping the end of life bit.ly/4rhIxoa

bmj.com

How patients explain and make sense of their decision for assisted suicide in Switzerland (the Exit Project): qualitative exploratory study

Objective To explore how people actively pursuing assisted suicide in Switzerland frame and report the motivations underpinning their decision. Design Qualitative exploratory study using semistructur...

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Andrew DeSio BBBBCCCCCCCIDPPPPS @andrewdesio.bsky.social · 15/09/2026

Is doxycycline ready to join the fight against pseudomonas UTIs? Let’s chat over on YouTube! youtube.com/shorts/zxgqL...

youtube.com

Is Doxycycline Ready to Join the Fight Against Pseudomonas UTIs?

YouTube video by KetamineRx

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Andrew DeSio BBBBCCCCCCCIDPPPPS @andrewdesio.bsky.social · 14/09/2026

Congrats! You’re BPS Board Certified! So… what’s in the tube? youtube.com/shorts/KUzJ3...

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Andrew DeSio BBBBCCCCCCCIDPPPPS @andrewdesio.bsky.social · 07/09/2026

New video tomorrow at 1800 central on the KetamineRx YouTube - gram negative guidance to fall asleep to! Over an hour of facts, insight, and tidbits about IDSA’s 2026 guidance!

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Andrew DeSio BBBBCCCCCCCIDPPPPS @andrewdesio.bsky.social · 30/08/2026

Wasn’t expecting this from wikiguidelines! Should be an awesome read, really looking forward to it! www.amjmed.com/article/S000...

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Andrew DeSio BBBBCCCCCCCIDPPPPS @andrewdesio.bsky.social · 22/08/2026

First Publication Alert! After multiple years of trying, various manuscripts, and several journals, I finally managed to get something published! Check it out here - Ultramassive transfusion in an urban level 1 trauma center: a case series - tsaco.bmj.com/content/11/3...

tsaco.bmj.com

Ultramassive transfusion in an urban level 1 trauma center: a case series

Objective This case series examines 27 trauma patients who met criteria for ultra massive transfusion protocol (UMTP), defined as receiving over 20 units of packed red blood cells (pRBCs) within 24 ho...

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Andrew DeSio BBBBCCCCCCCIDPPPPS @andrewdesio.bsky.social · 12/08/2026

Do You Really Need a Residency to be a Clinical Pharmacist? Join me over on YouTube for a brief discussion on ACCP’s recent paper on the need for residency and some alternative paths to the bedside, including a bit about my own! youtu.be/nei2Fdb5LbI?... via @YouTube

youtu.be

Do You Really Need a Residency to be a Clinical Pharmacist?

YouTube video by KetamineRx

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Andrew DeSio BBBBCCCCCCCIDPPPPS @andrewdesio.bsky.social · 28/07/2026

youtube.com/shorts/zp2dS... New on YouTube - is crit care board certification the Skeleton Key to better patient outcomes? Join me on YouTube to learn more and expect another video on Thursday!

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Andrew DeSio BBBBCCCCCCCIDPPPPS @andrewdesio.bsky.social · 27/07/2026

New gram negative guidance!? Already? I’ll take it! But where’s the updated pdf? Will have to break this one down! www.idsociety.org/practice-gui...

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Reposted by Andrew DeSio BBBBCCCCCCCIDPPPPS

Antibiotic Steward 🅱️C🆔🅿️🌟 @absteward.bsky.social · 17/06/2026

🔥Just published 🔥NEJM SNAP RCT In patients with MSSA bacteremia, cefazolin was noninferior to flucloxacillin or cloxacillin with respect to 90-day mortality and was associated with a lower incidence of acute kidney injury. #idsky www.nejm.org/doi/full/10....

nejm.org

Cefazolin for Methicillin-Susceptible Staphylococcus aureus Bacteremia | NEJM

Staphylococcus aureus bacteremia is associated with high mortality. Whether cefazolin or an antistaphylococcal penicillin should be preferred for the treatment of methicillin-susceptible S. aureus ...

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Andrew DeSio BBBBCCCCCCCIDPPPPS @andrewdesio.bsky.social · 15/06/2026

What happens when the mortality benefit of a miracle sepsis drug suddenly… disappears? Join me for a quick discussion on Xigris and the origins of Surviving Sepsis! youtube.com/shorts/DK98X...

youtube.com

Xigris, Eli Lilly, and the Surviving Sepsis Marketing Machine

YouTube video by KetamineRx

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Andrew DeSio BBBBCCCCCCCIDPPPPS @andrewdesio.bsky.social · 04/06/2026

This guy shows up to your emergency department, and the trauma team is asking for antibiotic recs. So, what do we cover with, and for how long? Join me on YouTube for a quick discussion on antibiotics for penetrating brain injuries! youtube.com/shorts/TsW3d...

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Andrew DeSio BBBBCCCCCCCIDPPPPS @andrewdesio.bsky.social · 01/06/2026

youtube.com/shorts/MpcQh... This was a fun one to research! How to treat hydrofluoric acid burns in a few minutes!

youtube.com

So You're Dissolving In A Barrel Of Hydrofluoric Acid... Now What?

YouTube video by KetamineRx

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Andrew DeSio BBBBCCCCCCCIDPPPPS @andrewdesio.bsky.social · 07/05/2026

youtu.be/Iv8bWucZapg?... Hey gang! Join me on YouTube for a deeper discussion on the data behind phenylephrine for septic shock! Full video is out now!

Phenylephrine IV bag being shot poorly into a trash can

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Andrew DeSio BBBBCCCCCCCIDPPPPS @andrewdesio.bsky.social · 02/05/2026

Feeding on pressors? Probably! Join me on YouTube for full videos, or Instagram and TikTok (KetamineRx everywhere) for more shorts like this!

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Andrew DeSio BBBBCCCCCCCIDPPPPS @andrewdesio.bsky.social · 19/04/2026

Stop by my YouTube and let's chat about PIPPEN - Is it time for to go There And Back Again with Pip-Tazo, or do we leave it back at Bag End until there's more data?

youtu.be

The PIPPEN Trial - A Second Breakfast for Zosyn in Penicillin-Allergic Patients?

YouTube video by KetamineRx

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Andrew DeSio BBBBCCCCCCCIDPPPPS @andrewdesio.bsky.social · 19/04/2026

Howdy BlueSky! Started a YouTube channel recently to share knowledge and have a little fun learning to shoot and edit videos! Stop by and check it out if you're interested, got a few videos up now! youtu.be/lRfe96SQp5Y?...

youtu.be

I Survived Surviving Sepsis 2026 - Was it Worth it?

YouTube video by KetamineRx

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Andrew DeSio BBBBCCCCCCCIDPPPPS @andrewdesio.bsky.social · 27/03/2025

It’s true what they say about reviewer 2! Time to fix up these manuscripts and resubmit, womp womp

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Andrew DeSio BBBBCCCCCCCIDPPPPS @andrewdesio.bsky.social · 26/03/2025

Enjoying a nice comfy break from social media and capturing a couple top 3 finishes while that’s still achievable! Gotta get better about coming back here, feel like I’m just not as caught up with the latest lit these days!

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Andrew DeSio BBBBCCCCCCCIDPPPPS @andrewdesio.bsky.social · 26/02/2025

These won’t last, but I’ll take the Ws and podiums when I can!

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Andrew DeSio BBBBCCCCCCCIDPPPPS @andrewdesio.bsky.social · 16/02/2025

Dang, first manuscript rejected from JTACS. At least lots of helpful feedback, hopefully we can rework things a bit and get it accepted somewhere. Fingers still crossed on the prospective paper, hopefully that one makes it!

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Reposted by Andrew DeSio BBBBCCCCCCCIDPPPPS

ID:IOTS Podcast @idiots-pod.bsky.social · 26/01/2025

ONE ANTIBIOTIC PK TABLE TO RULE THEM ALL Absorption takes drug into blood from GI, Vd spreads drug out to where bug calls home. And after bacteria are doomed to die, The drug’s eliminated on the porcelain throne In the Land of Notion where this table doth lie… #idSky #microsky #pharmsky #medsky

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Reposted by Andrew DeSio BBBBCCCCCCCIDPPPPS

Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 17/01/2025

Finally! Antibiotics are not non-inferior to appendectomy despite a generous 20% non-inferiority margin They are actually inferior: www.thelancet.com/journals/lan... in the @thelancet.bsky.social #MedSky

At 12-month follow-up, primary outcome data were available for 846 (90%) patients. Treatment failure occurred in 153 (34%) of 452 patients in the antibiotic group, compared with 28 (7%) of 394 in the appendicectomy group (difference 26·7%, 90% CI 22·4–30·9).

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Andrew DeSio BBBBCCCCCCCIDPPPPS @andrewdesio.bsky.social · 16/01/2025

Love this since every lab I’ve seen has topped out at 200+! Think my current one is 180+, with abnormal lab reported at >8 😢

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Reposted by Andrew DeSio BBBBCCCCCCCIDPPPPS

Jonathan Ryder, MD @jonathanrydermd.bsky.social · 16/01/2025

Important article for #AMSSky, #TxID, #UTISky, and #IDSky in @cidjournal.bsky.social: In neutropenic & non-neutropenic cancer patients w/ & w/o catheters, the absence of nitrite/leukocyte esterase or WBC<10 had high NPV for clinically significant bacteriuria academic.oup.com/cid/advance-...

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Reposted by Andrew DeSio BBBBCCCCCCCIDPPPPS

Tom Yates @tomayates.bsky.social · 10/01/2025

NEW PREPRINT! Enjoyed working with @tom-parks.bsky.social and @petedodd24.bsky.social on immortal time bias In its simplest form, ITB results from misallocation of person time, i.e. pre treatment time in intervention group being counted as time on treatment www.medrxiv.org/content/10.1... [1/n]

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Reposted by Andrew DeSio BBBBCCCCCCCIDPPPPS

Antibiotic Steward 🅱️C🆔🅿️🌟 @absteward.bsky.social · 04/01/2025

Recent studies reinforce the benefits of oral antibiotics, as well as shorter durations of therapy in BJIs with supporting evidence 🆕💫 Review article Bone Voyage: Navigating Updates in the Management of Bone and Joint Infections #idsky link.springer.com/article/10.1...

link.springer.com

Bone Voyage: Navigating Updates in the Management of Bone and Joint Infections - Current Infectious Disease Reports

Purpose of Review Advancements in the management of bone and joint infections (BJIs) aim to improve outcomes while challenging long-standing treatment practices. This review discusses key updates, inc...

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Reposted by Andrew DeSio BBBBCCCCCCCIDPPPPS

BK. Titanji @boghuma.bsky.social · 03/01/2025

What a cool study and a powerful demonstration that Tuberculosis is largely a disease of poverty. In Brazil a large scale intervention which provided cash monthly to families living in poverty led to profound reductions in TB cases. Up to 50% among the poorest groups. www.nature.com/articles/s41...

nature.com

Effects of conditional cash transfers on tuberculosis incidence and mortality according to race, ethnicity and socioeconomic factors in the 100 Million Brazilian Cohort - Nature Medicine

Participation in Brazil’s Bolsa Familia Program, one of the largest conditional cash transfer programs in the world, was associated with large reductions in tuberculosis incidence and mortality among ...

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Reposted by Andrew DeSio BBBBCCCCCCCIDPPPPS

Paul Sax @paulsaxmd.bsky.social · 03/01/2025

Though "Oral is the New IV" with antibiotics (h/t @bradspellberg.bsky.social), it's not always easy to convince reluctant inpatient clinicians -- especially (in my experience) surgeons, who want to treat "aggressively". Interesting dynamic ... blogs.jwatch.org/hiv-id-obser...

blogs.jwatch.org

On the Inpatient ID Consult Service, Oral Antibiotics Have a Rocky Road to Acceptance

Having just completed a stint doing inpatient ID consults, I came away impressed with three things: Staph aureus remains the Ruler of Evil Invasive Pathogens in the hospital setting. You can “jinx” a ...

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Andrew DeSio BBBBCCCCCCCIDPPPPS @andrewdesio.bsky.social · 01/01/2025

youtu.be/RRvYkrrpMKo?... Wow these are some absolute bops! Bunch of solid SNES era soundtracks on this guy’s channel too, on top of this one!

youtu.be

Waterworld (SNES) - Soundtrack

YouTube video by Dean Evans

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Reposted by Andrew DeSio BBBBCCCCCCCIDPPPPS

Ilan Schwartz @germhuntermd.bsky.social · 30/12/2024

Use of voriconazole to predict susceptibility and resistance to isavuconazole for Aspergillus fumigatus using CLSI methods and interpretive criteria High rate of agreement suggests vori susceptibility can predict isa susceptibility in A fumigatus w/ CLSI AFST journals.asm.org/doi/10.1128/...

Scattergram for Aspergillus fumigatus isavuconazole MIC (mg/L) vs voriconazole MIC (mg/L) using CLSI MIC breakpoint interpretive criteria. S, susceptible; I, intermediate; R, resistant)

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Reposted by Andrew DeSio BBBBCCCCCCCIDPPPPS

Andy Webb @ajwpharm.bsky.social · 30/12/2024

When AC is needed in acute cerebrovascular dz, heparin is usually chosen for its reversibility. Doses are often low-balled for safety, but does this come at a cost? Fast AC is needed in CSVT, and we saw that time to therapeutic PTT/AXa can >24h with low-intensity dosing! doi.org/10.1016/j.jo...

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Andrew DeSio BBBBCCCCCCCIDPPPPS @andrewdesio.bsky.social · 28/12/2024

Thinking about splurging a bit in 2025, utilizing some healthcare. Something crazy like that!

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