Science has forgotten that the greatest breakthroughs often come from outsiders who are able to take a fresh perspective.

Under a composite estimand strategy, the occurrence of the intercurrent event is incorporated into the endpoint definition, for instance by assigning a poor outcome value to patients who experience th...

I urge all readers of this thread to read the excellent new preprint from philosopher of science Veli-Pekka Parkkinen, “Choice of effect measure, extrapolation, and decision-making in patient care an...

Alt: a cartoon of homer simpson and marge simpson with the words you tried your best and you failed miserably, the lesson is never try.

There is clear evidence that tenofovir disoproxil fumarate combined with emtricitabine (TDF-FTC) is a highly efficacious oral pre-exposure prophylaxis agent for preventing the acquisition of HIV. This...

Abstract. Regression by composition is a new and flexible toolkit for building and understanding statistical models. Focusing here on regression models for

Miguel A. Hernán, MD, DrPH, professor of epidemiology, Harvard T.H. Chan School of Public Health, discusses Target Trial Emulation: A Framework for Causal Inference From Observational Data with JAMA Statistical Editor Roger J. Lewis, MD, PhD.

This paper proposes a new estimator of the variance of the Mantel-Haenszel estimator of common odds ratio that is easily computed and consistent in both sparse data and large-strata limiting models. M...

Funding should go to larger labs with many researchers, not to “principal investigators”

Estimands can be used in studies of healthcare interventions to clarify the interpretation of treatment effects. The addendum to the ICH E9 harmonised guideline on statistical principles for clinical ...