New experiments reveal how astrocytes tune neuronal activity to modulate our mental and emotional states. The results suggest that neuron-only brain models, such as connectomes, leave out a crucial la...

Astrocytes, the most abundant non-neuronal cell type in the brain, have traditionally been thought of as passive supporters of neuronal circuits. However, in recent years, work from many […]

Astrocyte signaling pathways influence neuronal networks and behavioral responses to neuromodulators

How astrocytes regulate neuronal circuits is a fundamental question in neurobiology. Specifically, how astrocytes respond to different neurotransmitters in vivo and how they affect downstream circuit ...

Locus ceruleus (LC)–derived norepinephrine (NE) drives network and behavioral adaptations to environmental saliencies by reconfiguring circuit functional connectivity, but the underlying synapse-level...

Both neurons and glia communicate through diffusible neuromodulators; however, how neuron-glial interactions in such neuromodulatory networks influence circuit computation and behavior is unclear. Dur...

AQuA2 is a powerful data analysis platform that decomposes time-lapse imaging datasets into elementary signaling events, allowing for accurate quantification of spatiotemporal molecular activity patte...