Project Tailwind is Coefficient Giving's call for founders to launch ambitious AI safety initiatives.

A blog focused on protecting humanity against biological threats and exploring the offense/defense balance of the physical world.

Radiology combines digital images, clear benchmarks, and repeatable tasks. But replacing humans with AI is harder than it seems.

Advocates won reforms for billions of factory-farmed animals

Almost half a million children under the age of 5 die of malaria each year. What if replacing a single amino acid in disease-carrying mosquitoes could help save them? After battling with rudimentary tools for millennia, malaria fighters are now armed with a potentially revolutionary technology. If only the public could get on board.

  Coefficient Giving’s Largest Grant Ever: $276 Million, Co-Funded With GiveWell, to the Against Malaria Foundation The combined $276 million grant — $212 million from Coefficient Giving and $64 million from GiveWell — will pay for bed nets in the Democratic Republic of the Congo, where malaria remains one of the leading causes of death […]

Each year, WHO’s World malaria report provides a comprehensive and up-to-date assessment of trends in malaria control and elimination across the globe

Strep A—the bacterium behind strep throat and impetigo—kills hundreds of thousands of people a year, mostly young people in LMICs—yet Strep A vaccine R&D is chronically underfunded.

Podcast Episode · Theory of Change · June 2 · 1h 6m

Coefficient Giving, one of the world’s largest effective-giving fun...

YIMBY has revealed its report on construction permit filing activity for the first quarter of 2026 across the five boroughs.

Today, Coefficient Giving is launching the Strep A Vaccine Fund, a multi-donor initiative to accelerate vaccine development against one of the world's most neglected infectious diseases relative to its scale. Strep A kills ~639,000 people a year. There is no vaccine. I think that can change 🧵

California's gubernatorial candidates are largely united on housing: Build more, faster. It marks a radical political shift in just eight years.

The End Kidney Deaths Act will end the kidney shortage, save 10,000 lives each year, and reduce taxes by $4 billion by supporting those who donate kidneys to strangers.

Epistemic conservatism no longer favours long timelines

After decades of scientific and regulatory delays, several Strep A vaccine candidates are entering clinical trials. Without further funding for phase 3 studies, however, many will be hamstrung.

Coefficient Giving is hiring a Managing Director, Philanthropic Advisory to lead our growing partnerships work, build a new advisory practice from the ground up, and help shape our organizational strategy as a member of our leadership team https://coefficientgiving.org/about-us/team/#leadership. We face a historic opportunity to scale philanthropic giving to the highest-impact causes, from global health and biosecurity to AI safety and beyond. We want to build the infrastructure to make that happen, with a goal of eventually directing more than $1 billion annually from donors beyond our founding partner, Good Ventures https://goodventures.org/. Your job is to build the bespoke advisory practice that supports the next generation of major philanthropists, while overseeing and expanding our current funds and partnership offerings. While the advisory function spans our full portfolio, we expect AI safety and biosecurity philanthropy to be a key part of your work. ABOUT COEFFICIENT GIVIN

Coefficient Giving directed over $1 billion in 2025, the most in our history. This significant milestone is the result of extraordinary dedication from our funders, staff, and grantees, who share the conviction that effective philanthropy can be a powerful lever for making the world a much better place.