iiinova — where your digital self keeps evolving

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Agnès Landemard @agnesland.bsky.social · 15/04/2026

How does blood flow relate to brain activity? We discovered that it reflects two neural populations affected oppositely by arousal. Together, they explain neurovascular coupling in all brain regions and brain states! Out today in Nature: rdcu.be/fdC2A @uclbrainscience.bsky.social

The supply of blood to brain tissue is thought to depend on the overall neural activity in that tissue, and this dependence is thought to differ across brain regions and across brain states. However, studies supporting these views have measured neural activity as a bulk quantity and related it to blood supply following disparate events in different regions. Here we measure fluctuations in neuronal activity and blood volume across the mouse brain, and find that their relationship is consistent across brain states and brain regions but differs in two opposing brainwide neural populations. Functional ultrasound imaging (fUSI) revealed that whisking, a marker of arousal, is associated with brainwide fluctuations in blood volume. Simultaneous fUSI and Neuropixels recordings showed that neurons that increase activity with whisking have distinct haemodynamic response functions compared with those that decrease activity. Their summed contributions predicted blood volume across states.Brainwide Neuropixels recordings revealed that these opposing populations coexist in the entire brain. Their differing contributions to blood volume largely explain the apparent differences in blood volume fluctuations across regions. The mouse brain thus contains two neural populations with opposite relations to brain state and distinct relationships to blood supply, which together account for brainwide fluctuations in blood volume.

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Georg Keller @georgkeller.bsky.social · 15/04/2026

For nearly a century, we believed the therapeutic effect of ECT is the seizure. Our latest research suggests we may have been looking at the wrong event. A thread on why cortical spreading depression (CSD) might be the driver of therapeutic benefit. Work led by @therehugolad.bsky.social

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Roozbeh Kiani @roozbehkiani.bsky.social · 07/04/2026

The US/Iran war and escalating rhetoric are already disrupting civilian life and academic infrastructure across the region. We drafted a letter in defense of academic life, and to mobilize concrete support for affected students, scholars, and collaborations. Please check Sepi’s message and sign.

sites.google.com

Protect Academic Life in Iran

We, the undersigned academics and researchers from around the world, express our profound concern over recent military strikes on Iran, the retaliatory responses, and the reported impact on civilian l...

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Sepiedeh Keshavarzi @sepikeshavarzi.bsky.social · 07/04/2026

When universities and research institutions become military targets, academics cannot remain silent. I co-initiated an open letter calling for global academic solidarity and support for affected students and scholars. Please share. to read and sign: sites.google.com/view/protect...

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Julie Fabre @juliefabre.bsky.social · 08/04/2026

How do the basal ganglia turn what you see into what you do? New preprint w/ @kenneth-harris.bsky.social, @flickerfusion.bsky.social & @carandinilab.net: we recorded across striatum, GPe & SNr in a Go/NoGo task. Striatum encodes which stimulus, GPe & SNr encode action. 🧵 biorxiv.org/content/10.6...

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Emilie Macé @mace-lab.bsky.social · 08/04/2026

1/8. New preprint! ✨ How spontaneous is spontaneous behavior? 🧠🐭 We found that whole-brain fUSi signals predicted spontaneous behavioral transitions seconds in advance. Inhibiting one node of this transition-prone state, the medial septum, facilitated switching! www.biorxiv.org/content/10.6...

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Tim Behrens @behrenstimb.bsky.social · 19/03/2026

Cosyne is always the best week of the year but this year it was just spectacular. Congrats @neurokim.bsky.social, @markhisted.org, @glajoie.bsky.social, and Alex Cayco Gajic for one of the best programs ever.

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Dennis London @dennislondon.bsky.social · 12/02/2026

The basal ganglia output is often framed as a motor gate: corticostriatal circuits select an action, then GPi/SNr-thalamus helps release it. In humans, we find this same pathway carries cognitive variables embedded in movement signals—and even produces learning-relevant signals after feedback. 1/10

biorxiv.org

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Sam Gershman @gershbrain.bsky.social · 09/01/2026

With some trepidation, I'm putting this out into the world: gershmanlab.com/textbook.html It's a textbook called Computational Foundations of Cognitive Neuroscience, which I wrote for my class. My hope is that this will be a living document, continuously improved as I get feedback.

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Mark D Humphries @markdhumphries.bsky.social · 30/12/2025

Just published my review of neuroscience in 2025, on The Spike. The 10th of these, would you believe? This year we have foundation models, breakthroughs in using light to understand the brain, a gene therapy, and more Enjoy! medium.com/the-spike/20...

medium.com

2025: A Review of the Year in Neuroscience

Enlightening the brain

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Rui Ponte Costa @somnirons.bsky.social · 02/01/2025

🚨Our paper on how the cerebellum learns to drive cortical dynamics for rapid task learning and switching, which we propose can then be consolidated in the cortex @naturecomms.bsky.social nature.com/articles/s41... 🧠 #compneuro

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