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Adhithya Sankar

@adhithyasankar.bsky.social
71 followers 87 following 10 posts

Endocrinologist. Salford Royal Hospital, UK. Previously @UoM. Dad, hiker and nature lover 🏞️

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Adhithya Sankar @adhithyasankar.bsky.social · 08/08/2026
academic.oup.com/ejendo/artic...
academic.oup.com
Effects of GLP-1 receptor agonists on copeptin in euvolemic participants
AbstractObjective. Glucagon-like peptide-1 (GLP-1) plays an important modulatory role in sodium and water homeostasis. Recent studies demonstrated that lon
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Reposted by Adhithya Sankar
Society for Endocrinology @socendocrinology.bsky.social · 30/01/2026
In The #Endocrinologist, @safwaanadam.bsky.social and @akheelsyed.bsky.social, describe the various biological effects of obesity in worsening the health of the heart muscle and blood vessels, and how weight loss treatments have benefits for cardiovascular health too. 🫀 Read more👉 shorturl.at/KML5v
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akheel sͩyͬed @akheelsyed.bsky.social · 11/01/2026
Thyroid overactivity worsens patients' quality of life (QoL). After treatment, QoL is not completely restored for many patients. We discuss reasons, and new approaches to address long-term effects on QoL. @ncaresearchnhs.bsky.social @endoconnect.bsky.social www.researchgate.net/publication/...
researchgate.net
Prioritizing Quality of Life in the management of hyperthyroidism—An expert clinical perspective | Request PDF
Request PDF | Prioritizing Quality of Life in the management of hyperthyroidism—An expert clinical perspective | Hyperthyroidism adversely affects quality of life (QoL), encompassing physical, mental ...
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akheel sͩyͬed @akheelsyed.bsky.social · 10/01/2026
What's the diagnosis? Be warned: Not everything is as it seems! Ali, @adhithyasankar.bsky.social, et al. @ncaresearchnhs.bsky.social www.ccjm.org/content/93/1...
ccjm.org
A young woman with Kallmann syndrome and acute neurologic symptoms
Diagnoses considered on initial presentation included conditions that present with stroke-like symptoms such as seizure, hemiplegic migraine, transient ischemic attack, and brain tumor.
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Adhithya Sankar @adhithyasankar.bsky.social · 17/10/2025
Time for wider adoption of salivary cortisone in endocrinology? @akheelsyed.bsky.social @addisonsdisease.bsky.social @socendocrinology.bsky.social #AdrenalInsufficiency #Endocrinology #SalivaryCortisone jamanetwork.com/journals/jam...
jamanetwork.com
Adult Adrenal Insufficiency
To the Editor In the recent Review on adrenal insufficiency in adults,1 the authors discussed noninvasive diagnostic approaches such as salivary cortisol sampling, which is widely used in the assessme...
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akheel sͩyͬed @akheelsyed.bsky.social · 15/10/2025
Adult Adrenal Insufficiency url: jamanetwork.com/journals/jam... The role and value of salivary Cortisone test in investigation of Adrenal Insufficiency in adults
jamanetwork.com
Adult Adrenal Insufficiency
To the Editor In the recent Review on adrenal insufficiency in adults,1 the authors discussed noninvasive diagnostic approaches such as salivary cortisol sampling, which is widely used in the assessme...
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Adhithya Sankar @adhithyasankar.bsky.social · 22/06/2025
www.nejm.org/doi/full/10....
nejm.org
Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes | NEJM
Orforglipron is a small-molecule, nonpeptide glucagon-like peptide-1 (GLP-1) receptor agonist in clinical development for type 2 diabetes and weight management. Additional data on the efficacy and ...
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Diabetologia @diabetologiajnl.bsky.social · 03/06/2025
Does every person with type 2 diabetes respond the same way to GLP-1 receptor agonists? Recent clinical data suggest otherwise. #GLP1 #diabetes link.springer.com/article/10.1... 🔓
link.springer.com
Heterogeneity in response to GLP-1 receptor agonists in type 2 diabetes in real-world clinical practice: insights from the DPV register – an IMI-SOPHIA study - Diabetologia
Aims/hypothesis Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are a cornerstone in type 2 diabetes management. In this study we evaluated heterogeneity in body weight and glycaemic responses t...
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The Lancet Diabetes & Endocrinology @thelancetendo.bsky.social · 29/03/2025
#Adrenocortical #carcinoma is a rare malignancy, in contrast to benign #adrenal tumours, which are among the most common human neoplasias with a prevalence of greater than 3% in adults older than 50 years www.thelancet.com/journals/lan... #OpenAccess #MedSky #EndoSky #OncSky
thelancet.com
Adrenocortical carcinoma: a practical guide for clinicians
Adrenocortical carcinoma is a rare endocrine malignancy. The management of patients with adrenocortical carcinoma is challenging for several reasons, including its heterogeneous but frequently aggress...
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Adhithya Sankar @adhithyasankar.bsky.social · 23/03/2025
www.nature.com/articles/s41...
nature.com
GLP-1 receptor agonists causing euglycemic ketoacidosis in patients without diabetes: a brief review - International Journal of Obesity
International Journal of Obesity - GLP-1 receptor agonists causing euglycemic ketoacidosis in patients without diabetes: a brief review
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Daniel Drucker @danieljdrucker.bsky.social · 08/03/2025
How to think about evaluation of low testosterone levels, SHBG, clinical symptoms and possible benefits vs. real risks of treatment in the context of #obesity academic.oup.com/jcem/advance...
academic.oup.com
Approach to the patient: Low testosterone concentrations in men with obesity
Abstract. Pathologic hypogonadism occurs when serum testosterone is significantly and persistently reduced by irreversible organic (structural, genetic) di
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GoggleDocs @goggledocs.bsky.social · 05/03/2025
#Finerenone: CV & renal protection across all #T2D therapies❗️ 🔹 Pooled analysis: 15,365 pts w/ T2D + CKD or CV 🔸 Consistent benefit on 💔☠️, 🏥💔& kidney outcomes 🔹 ⤴️K+ ⤵️ with SGLT2i use 🔸 Benefit independent of SGLT2i/GLP-1 use 👉 Supports finerenone as a 🎯 in high-risk #T2D❗️ 🔗 ggdocs.co/tx2a5r
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Adhithya Sankar @adhithyasankar.bsky.social · 25/02/2025
academic.oup.com/ejendo/advan...
academic.oup.com
Delphi Panel consensus on recommendations for thromboprophylaxis of venous thromboembolism in endogenous Cushing's syndrome: a Position Statement
AbstractObjective. To establish recommendations for thromboprophylaxis in patients with endogenous Cushing's syndrome (CS), addressing the elevated risk of
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Adhithya Sankar @adhithyasankar.bsky.social · 11/02/2025
Pleased to share our case report! RAI is known to worsen TED in Graves’ disease, but what about nodular thyroid disease? Assessment of TPO antibody, and not just TRAb prior to RAI may be informative in guiding decision-making around steroid prophylaxis. casereports.bmj.com/content/18/2...
casereports.bmj.com
De novo Graves’ thyroid eye disease after radioiodine treatment for toxic nodular thyroid disease
It is well known that radioactive iodine treatment (RAI) for thyrotoxicosis in Graves’ disease can precipitate worsening of thyroid eye disease (TED), particularly in susceptible patients. Less common...
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akheel sͩyͬed @akheelsyed.bsky.social · 07/02/2025
Obesity is the third most important predictor of heart disease. We discuss pathophysiology and management including roles of anti-obesity medications and bariatric surgery. @ncaresearchnhs.bsky.social www.sciencedirect.com/science/arti...
sciencedirect.com
Obesity Management for Patients with Coronary Artery Disease and Heart Failure
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akheel sͩyͬed @akheelsyed.bsky.social · 03/02/2025
Accurate prediction of long-term postoperative weight loss is important for advising patients undergoing bariatric surgery. @adhithyasankar.bsky.social et al. pubmed.ncbi.nlm.nih.gov/39887840/ @ncaresearchnhs.bsky.social
pubmed.ncbi.nlm.nih.gov
Actual weight loss trajectories after bariatric surgery compared with the SOPHIA prediction tool: An observational comparison study - PubMed
The SOPHIA study tool provides accurate postoperative weight forecasts for some subgroups of patients, but its precision diminishes with time. This study reiterates the necessity for better personaliz...
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Adhithya Sankar @adhithyasankar.bsky.social · 30/01/2025
How well can we predict weight loss after bariatric surgery? Our study assessed the SOPHIA weight prediction tool in our patient population. dom-pubs.pericles-prod.literatumonline.com/doi/10.1111/...
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GoggleDocs @goggledocs.bsky.social · 18/01/2025
Peri-operative management of GLP-1 RAs & SGLT2 inhibitors❗️ 🔹 New 🇬🇧 consensus: GLP-1 RAs can continue, but risks of aspiration must be assessed. 🔸SGLT2i should be stopped 1 day pre-op to avoid euglycemic DKA. ❗️shared decision-making & tailored approaches to optimise safety. 🔗 ggdocs.co/4r995z
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NEJM.org @nejm.org · 23/12/2024
🧵 Cancer Cachexia and the Brain Stem (a thread) In NEJM, Groarke et al. report the results of a phase 2 clinical trial of ponsegromab therapy for cancer cachexia in patients with elevated humoral levels of growth differentiation factor 15 (GDF-15). nej.md/3XE645a 1/10 #MedSky #ScienceSky
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Adhithya Sankar @adhithyasankar.bsky.social · 10/12/2024
jnnp.bmj.com/content/earl...
jnnp.bmj.com
Cardiovascular risk and obesity impact loss of grey matter volume earlier in males than females
Background It remains imperative to discover the time course that cardiovascular risk factors influence neurodegeneration in males and females and decipher whether the apolipoprotein (APOE) genotype m...
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akheel sͩyͬed @akheelsyed.bsky.social · 06/12/2024
www.telegraph.co.uk/health-fitne...
telegraph.co.uk
The real reason men get belly fat (and how to get rid of it)
Research suggests it’s more dangerous to be an overweight man than woman. Here’s why – and what you can do about it
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Adhithya Sankar @adhithyasankar.bsky.social · 09/12/2024
Eye-opening patient story regarding ACC and mitotane
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Sarah Finer @sarahfiner.bsky.social · 26/11/2024
It’s a big day for @genesandhealth.bsky.social @samcbhodgson.bsky.social @moneeza-ks.bsky.social Genes & Health, with @ Sam Hodgson, Moneeza Kalhan Siddiqui and I, as we publish our paper rdcu.be/d1vj0 on the genetic basis of #type2diabetes & #gestationaldiabetes (#T2D and #GDM) in south Asians. A🧵
rdcu.be
Genetic basis of early onset and progression of type 2 diabetes in South Asians
Nature Medicine - In a cohort of 50,556 South Asian individuals, partitioned polygenic scores helped identify genetic susceptibility to insulin deficiency and unfavorable fat distribution as key...
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AMEND UK @amenduk.bsky.social · 20/11/2024
Presentation and management of patients with adrenal masses: a large tertiary centre experience by Onnicha Suntornlohanakul et al @Bham_AT doi.org/10.1093/ejen... #adrenal #phaeochromocytoma #ACC
doi.org
Presentation and management of patients with adrenal masses: a large tertiary centre experience
AbstractBackground. Adrenal masses are found in up to 5%-7% of adults. The 2016 European guidelines on the management of adrenal incidentalomas have standa
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Current Biology @currentbiology.bsky.social · 25/11/2024
How the #brain talks to the #gut and vice versa! 🧪🧠💩 Check out the great primer on gut-brain communication and #interoception by @amberalhadeff.bsky.social and Nilay Yapici 👇👇👇 www.cell.com/current-biol...
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Joel Topf @kidneyboy.bsky.social · 19/11/2024
Honey, stop what you're doing, new hyponatremia research just dropped! What's it say? It looks like slow correction is associated with worse outcomes, like death and length of stay! Was it just a small study? No, it was a meta-analysis of almost 12,000 patients! jamanetwork.com/journals/jam...
jamanetwork.com
Correction Rates and Clinical Outcomes in Hospitalized Adults With Severe Hyponatremia
This systematic review and meta-analysis evaluates the association of sodium correction rates with mortality among hospitalized adults with severe hyponatremia.
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GoggleDocs @goggledocs.bsky.social · 16/11/2024
Expert statement on Diagnosis & Mx of peripheral neuropathy in #diabetes & pre-diabetes (Gulf region) 🔸suggest routine screening (patient questionnaire & clinical assessment) 🔹Universal B12 Rx 🔸Check B 1&6 levels 🔹Use of CGM 🔸Use of GLP1 🔗 link.springer.com/article/10.1...
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