Nature Reviews Endocrinology, Published online: 02 October 2026; doi:10.1038/s41574-026-01311-3As highly potent weight loss drugs become available, interest grows in whether repeated cycles of weight loss and regain can exacerbate obesity. We argue that weight cycling might contribute to the development of obesity in susceptible lean individuals but seems to have little effect on the progression of obesity and its complications.

Abstract. Non-medical androgen use, commonly involving anabolic–androgenic steroids, represents an increasing public health concern. Non-medical androgen use is associated with significant morbidity a...

This case shows that porcine kidney xenotransplantation can provide prolonged renal support and be discontinued without clinically significant allosensitisation or zoonotic infection. Early cellular r...

ContextPrader-Willi syndrome is a genetic neurodevelopmental disorder characterized by hyperphagia and early-onset obesity from hypothalamic dysfunction with...

Operation type, age, sex, preoperative body mass index, diabetes, operation type and smoking had significant associations with weight loss while age, hypertension, Index of Multiple Deprivation and initial postoperative weight loss had significant associations with recurrent weight gain.

The Risk of GLP-1 Receptor Agonist (GLP-1 RA) Exposure in Early Pregnancy. A Call to Action: Quantifying the Impact on Pregnancy Outcomes in the United Kingdom

To the Editor: In their review article, Giustina and Colao (November 13 issue)1 discuss acromegaly and its craniofacial manifestations. Dentists and oral and maxillofacial surgeons are often among ...

Request PDF | Prioritizing Quality of Life in the management of hyperthyroidism—An expert clinical perspective | Hyperthyroidism adversely affects quality of life (QoL), encompassing physical, mental ...

Diagnoses considered on initial presentation included conditions that present with stroke-like symptoms such as seizure, hemiplegic migraine, transient ischemic attack, and brain tumor.

<span><b><i>Background:</i></b> There is evidence of quality of life (QoL) impairment and weight gain in treated hyperthyroidism. It is not known whether treatment-related weight gain is associated with QoL impairment in this patient group of this cohort. Our primary aim was to examine whether percentage</span> …

The Society for Endocrinology aims to promote the advancement of public education in endocrinology

A 47-year-old man with discomfort in the upper chest, difficulty swallowing food and drinks, and weight loss of 10 kg over 2 months underwent computed tomography (CT), which excluded malignancy but sh...

A 47-year-old man with discomfort in the upper chest, difficulty swallowing food and drinks, and weight loss of 10 kg over 2 months underwent computed tomography (CT), which excluded malignancy but sh...

Long-term outcomes of Roux-en-Y gastric bypass (RYGB) in adolescents are limited. This systematic review and meta-analysis evaluates the safety and efficacy of RYGB in adolescents with obesity. A comp...

To the Editor In the recent Review on adrenal insufficiency in adults,1 the authors discussed noninvasive diagnostic approaches such as salivary cortisol sampling, which is widely used in the assessme...

To the Editor In the recent Review on adrenal insufficiency in adults,1 the authors discussed noninvasive diagnostic approaches such as salivary cortisol sampling, which is widely used in the assessme...

International Journal of Obesity - Effects of tirzepatide on weight management in patients with and without diabetes: a systematic review and meta-analysis

Orforglipron, a small-molecule, nonpeptide oral glucagon-like peptide-1 (GLP-1) receptor agonist, is being investigated as a treatment for obesity. In this phase 3, multinational, randomized, doubl...

Obesity and metabolic syndrome are global health challenges, significantly increasing risks for type 2 diabetes, cardiovascular and cerebrovascular diseases, and overall mortality. This narrative revi...

The US Food and Drug Administration has approved the weight loss drug semaglutide, marketed as Wegovy, for the treatment of patients with a severe form of liver disease called metabolic associated ste...

Doctors could soon be offering sodium-glucose cotransporter-2 (SGLT-2) inhibitors as a first line treatment option for all patients with diabetes, not just those with heart disease.1 The change has b...

Use of incretin-based therapies in women using hormone replacement therapy (HRT)

More than half the patients with hyperthyroidism had ≥10% PWG post-treatment. Indicators of disease severity, namely disease-related weight loss and baseline thyroid hormones, were predictive of exces...

NEW BMS Tool for Clinicians – Use of incretin-based therapies in women using HRT

Aisha Awan and colleagues argue for nationally funded training programmes for the integration of displaced refugee and asylum seeking healthcare professionals Wars in Gaza, Lebanon, Sudan, Syria, Ukr...

Accurately determining food intake remains a substantial challenge in nutrition research. This issue of Nature Metabolism introduces a methodology for assessing dietary intake, using stool metagenomic...

Objective To provide clinicians involved in managing menopause with a summary of current evidence surrounding menopause hormone therapy (MHT). Design The authors evaluate and synthesize existing p...

The SOPHIA study tool provides accurate postoperative weight forecasts for some subgroups of patients, but its precision diminishes with time. This study reiterates the necessity for better personaliz...

Obesity Surgery -

In a crossover trial evaluating semaglutide versus placebo as an add-on to automated insulin delivery therapy in adults with type 1 diabetes, the use of semaglutide was associated with an increased pe...

Maladie de Cushing et hypertension liées à un adénome surrénal unilatéral non fonctionnel

Research suggests it’s more dangerous to be an overweight man than woman. Here’s why – and what you can do about it

Find out more about the Bicentenary PhD Studentships and Fellowships for researchers with an interest in discovery and innovation in bioscience, biomedical and health research.