AIR, a minimal 15-amino acid motif, enables rapid, activation-dependent shedding of surface receptors through ADAM17, allowing T cells to autonomously tune receptor expression. AIR reduces tonic CAR s...

Clues to a modern mystery could be lurking in information collected generations ago.

Humoral immunological memory mediated by memory B cells (MBCs) and long-lived plasma cells (LLPCs) is critical for sustained protection following infe…

Clean living conditions that lessen exposure to microorganisms are linked to an increase in allergies. Mouse data reveal how the environment affects allergic immune responses.

How do intellectual property rights and licensing structures influence access to CRISPR technologies? Could the right to science act as a complementary legal instrument to promote socially beneficial ...

Cytokines optimize and fine-tune effector T cell responses. Here, Jiang et al. utilize IL-9, with scarce receptor expression in normal tissues, to boost IL-9R engineered T cells for cancer therapy. IL...

So far, immune cells that have been engineered to kill cancers, known as CAR T-cells, haven’t worked well against solid cancers - but a study in mice suggests that could soon change

CAR-T cells are engineered to express CBD-IL-12 upon STEAP1 recognition to enhance tumour-specific immune responses in mice.

Mary Brunkow, Fred Ramsdell and Shimon Sakaguchi discovered cells that protect the body from autoimmune diseases.

Nature - Rapid extracellular antibody profiling reveals a contribution of autoantibodies to the effectiveness of checkpoint immunotherapy for cancer.

Protein engineering through the ligation of polypeptide fragments has proven enormously powerful for studying biochemical processes. In general, this strategy necessitates a final protein-folding step...