iiinova — where your digital self keeps evolving

Journal of Clinical Investigation @jci.org · 54m

The promise of new approach methodologies: doi.org/10.1172/JCI2... In this Review, Joseph C. Wu & colleagues describe how new approach methodologies—human cell-based technologies and computational models—could improve cardiometabolic drug development.

000

Journal of Clinical Investigation @jci.org · 54m

000

Journal of Clinical Investigation @jci.org · 3h

As part of JCI’s review series on emerging therapeutic strategies in #BreastCancer, Walmsley et al. present: Expanding the therapeutic scope of PARP inhibitors in breast cancer: current indications and future directions: doi.org/10.1172/JCI2...

000

Journal of Clinical Investigation @jci.org · 5h

Targeting neutrophil effector function reduces GVHD: doi.org/10.1172/JCI2... Cover: Holzmüller et al. @uniklinik-fr.bsky.social report that pegtarazimod, a peptide drug that reduces neutrophil effector functions, limits acute GVHD mortality & severity in mice and is tolerated in patients.

101

Journal of Clinical Investigation @jci.org · 30/09/2026

In this working model inhibition of LSD1 by its specific inhibitor ORY- 1001 could reduce LSD1 expression, and treatment with senolytic drugs (Dasatinib and Quercetin) could ameliorate cellular senescence and organ aging.

000

Journal of Clinical Investigation @jci.org · 30/09/2026

Could targeting LSD1 be a novel strategy to decrease senescence, organ aging, and hair graying? doi.org/10.1172/JCI1... Zhang et al. demonstrate LSD1 as a key regulator of DNA damage-induced senescence and organ aging and highlights it as a promising therapeutic target.

120

Journal of Clinical Investigation @jci.org · 29/09/2026

Casalino-Matsuda et al. analyzed serially collected alveolar samples from unvaccinated patients with severe #SARSCoV2 pneumonia treated with Auxora vs placebo & find Auxora reprograms pathogenic alveolar macrophage–T cell circuits in viral pneumonia: doi.org/10.1172/JCI2... catgaohow.bsky.social

000

Journal of Clinical Investigation @jci.org · 28/09/2026

For the first time, gene therapy successfully treats Cockayne Syndrome in mice: doi.org/10.1172/JCI1... Batista et al. show the AAV-mediated gene therapy corrected the DNA damage hypersensitivity of CSA-deficient human cells extended lifespan safely in mice.

011

Journal of Clinical Investigation @jci.org · 28/09/2026

DEG-77 in combination with ribociclib improves progression-free survival in a CDK4/6i-refractory preclinical model of ER+/Her2– breast cancer: doi.org/10.1172/JCI1...

000

Journal of Clinical Investigation @jci.org · 28/09/2026

Presenting phosphorylated FADD as a novel driver of resistance in breast cancer: doi.org/10.1172/JCI1... Awadia et al. find that blocking FADD phosphorylation restored CDK4/6 inhibitor sensitivity and improved tumor control in resistant ER+ breast cancer models.

110

Journal of Clinical Investigation @jci.org · 27/09/2026

Sunday Read💫: The difference between cysts & no cysts in polycystic kidney disease. Li et al. @yalenephrology.bsky.social show that upstream protein translation on the PKD1 transcript blunts PC1 expression & can be blocked to therapeutically increase expression in PKD: doi.org/10.1172/JCI2...

032

Journal of Clinical Investigation @jci.org · 26/09/2026

Weekend highlight💫: Targeting ferroptosis in heart and kidney disease: doi.org/10.1172/JCI2... In this Review, Hossein Ardehali @hosseinardehali.bsky.social & colleagues describe the diverse physiological and pathological roles of ferroptosis and its potential as a therapeutic target.

031

Journal of Clinical Investigation @jci.org · 25/09/2026

TGF-β serves as a critical signaling determinant of liver progenitor cell activation and function: doi.org/10.1172/JCI1...

010

Journal of Clinical Investigation @jci.org · 25/09/2026

A potential therapeutic target for liver failure. Tong et al. @uniheidelberg.bsky.social explore the repair process in liver failure using several models, reporting that TGF-β serves as a critical signaling determinant of liver progenitor cell activation & function: doi.org/10.1172/JCI1...

110

Journal of Clinical Investigation @jci.org · 24/09/2026

Could excess complement activation lead to more thrombosis and miscarriages? doi.org/10.1172/JCI2... Using mouse models, Smid et al. reveal cooperation between platelets, coagulation, and complement in establishing maternal blood flow to the placenta.

021

Journal of Clinical Investigation @jci.org · 23/09/2026

From silos to synergy: The interdisciplinary discovery potential in redefining polyendocrine metabolic ovarian syndrome: doi.org/10.1172/JCI2... Morhaus et al. provide a Commentary on Morhaus et al.: doi.org/10.1172/JCI1... #PMOS #PCOS

000

Journal of Clinical Investigation @jci.org · 23/09/2026

Here is a sneak peek at the Commentary highlight by Morhaus et al.: doi.org/10.1172/JCI2...

000

Journal of Clinical Investigation @jci.org · 23/09/2026

Highlighting the genetic architecture bridging ovarian and metabolic mechanisms in PMOS doi.org/10.1172/JCI1... Nguyen et al. integrate human and mouse genetic data to reveal connections between reproductive, endocrine, and cardiometabolic aspects of PMOS/PCOS.

100

Journal of Clinical Investigation @jci.org · 22/09/2026

The difference between cysts & no cysts in polycystic kidney disease: doi.org/10.1172/JCI2... Li et al. @yalenephrology.bsky.social show that upstream protein translation on the PKD1 transcript blunts Polycystin-1 expression & can be blocked to therapeutically increase expression in PKD

022

Journal of Clinical Investigation @jci.org · 21/09/2026

Going to the source: pancreatic lymph nodes maintain stem-like CD8+ T cells in human type 1 diabetes: doi.org/10.1172/JCI2... Fatoumata Samassa, Sylvaine You, & Roberto Mallone @institutcochin.bsky.social write a Commentary on Peters et al.: doi.org/10.1172/JCI1...

000

Journal of Clinical Investigation @jci.org · 21/09/2026

Pancreatic lymph nodes house T1D-like CD8 T cells with self-renewing features doi.org/10.1172/JCI1... Todd M Brusko @bruskolab.bsky.social & team profiled T cells in T1D, highlighting a stem-like population in lymph nodes as a potential source for pancreatic autoreactive T cells.

110

Journal of Clinical Investigation @jci.org · 20/09/2026

2/ Cilia–to–basement membrane signaling initiates cystogenesis in the #kidney doi.org/10.1172/JCI1... Mazloum et al. @inem-necker.bsky.social link polycystin-1 loss in ADPKD to tubule basement membrane remodeling in a model that implicates both luminal and basolateral mechanisms in cyst formation.

000

Journal of Clinical Investigation @jci.org · 20/09/2026

1/ Highlighting authors behind the Cover💫: Coauthors (from left to right), Manal Mazloum, Frank Bienaimé, Vicky Scata, & Rushdi Alghamdi are featured here working @inem-necker.bsky.social in Paris, France with one of the TEM microscopes used to demonstrate basement membrane thinning in #ADPKD

110

Journal of Clinical Investigation @jci.org · 19/09/2026

Obesity enhances HO formation and impairs functional recovery after injury: doi.org/10.1172/JCI2...

010

Journal of Clinical Investigation @jci.org · 19/09/2026

Saturday spotlight💫: Dietary omega-6 lipids drive aberrant tissue repair in #obesity: doi.org/10.1172/JCI2... Obesity is linked to impaired healing, including #HeterotopicOssification (HO) at the injury site. Benjamin Levi & team implicate dietary #Omega6 lipids in this elevated risk for HO.

111

Journal of Clinical Investigation @jci.org · 18/09/2026

Targeting ferroptosis in heart and kidney disease: doi.org/10.1172/JCI2... In this Review, Hossein Ardehali @hosseinardehali.bsky.social & colleagues describe the diverse physiological and pathological roles of ferroptosis and its potential as a therapeutic target.

000

Journal of Clinical Investigation @jci.org · 17/09/2026

Commentary: Imaging B-Cell Maturation Antigen in Multiple Myeloma: doi.org/10.1172/JCI2... Yangmeihui Song, Wenyu Song, & Weibo Cai discuss Gu et al.: doi.org/10.1172/JCI2...

020

Journal of Clinical Investigation @jci.org · 17/09/2026

Here is a peek at the Commentary by Song et al.: doi.org/10.1172/JCI2...

010

Journal of Clinical Investigation @jci.org · 17/09/2026

BCMA imaging enables a more complete picture of multiple myeloma doi.org/10.1172/JCI2... Gu et al. show that a BCMA-targeted PET tracer measures both tumor burden and disease activity in multiple myeloma with superior sensitivity and selectivity to metabolic imaging.

120

Journal of Clinical Investigation @jci.org · 16/09/2026

Nominating CARD8 and Caspase-1 as therapeutic targets for patients with Hatipoglu syndrome: doi.org/10.1172/JCI2... Xiao et al. @yaleschoolofmed.bsky.social develop a new way to model this human genetic disease and discover why patients with DPP9 deficiency have loss of blood cells.

000

Journal of Clinical Investigation @jci.org · 16/09/2026

This year’s theme for #PeerReviewWeek is Peer Review Capacity: Volume, Speed, and Quality. In today's changing publishing landscape, we commend our reviewers for meeting the demands, maintaining the highest standards, and staying true to the peer review process. Thank you Reviewers! #PRW #PRW2026

020

Journal of Clinical Investigation @jci.org · 16/09/2026

Understanding migraine mechanisms: doi.org/10.1172/JCI2... Hemiplegic migraine involves headache preceded by motor weakness. In this Review, Daniela Pietrobon discuss the genetics of this condition, and potential approaches to treat the pain and motor symptoms.

010

Journal of Clinical Investigation @jci.org · 15/09/2026

Evidence for a tubular basement membrane-cilia connection in autosomal dominant #PolycysticKidneyDisease pathogenesis: doi.org/10.1172/JCI2... Caroline R Sussman & Peter C Harris @mayoclinic.org comment on Mazloum et al.: doi.org/10.1172/JCI1... #PKD #KidneyResearch

000

Journal of Clinical Investigation @jci.org · 15/09/2026

Behind the Scenes: Coauthors (from left to right), Manal Mazloum, Frank Bienaimé, Vicky Scata, & Rushdi Alghamdi working @inem-necker.bsky.social in Paris, France with one of the TEM microscopes used to demonstrate basement membrane thinning in ADPKD

130

Journal of Clinical Investigation @jci.org · 15/09/2026

Cilia–to–basement membrane signaling initiates cystogenesis in the kidney doi.org/10.1172/JCI1... The Cover features work by Mazloum et al. @inem-necker.bsky.social showing basement membrane remodeling drives cyst formation in autosomal dominant kidney disease

132

Journal of Clinical Investigation @jci.org · 14/09/2026

Sensory Neuron BRAF Mediates Opioid-Induced Hyperalgesia and Tolerance via Presynaptic NMDA Receptor Hyperactivity: doi.org/10.1172/JCI2...

000

Journal of Clinical Investigation @jci.org · 14/09/2026

Opioid use can worsen pain over time by increasing pain sensitivity while decreasing its relief Here, Hui-Lin Pan & team report that opioids activate the cancer-related protein kinase BRAF in sensory neurons to increase pain signaling: doi.org/10.1172/JCI2...

100

Journal of Clinical Investigation @jci.org · 14/09/2026

GLP-1–targeted therapies for alcohol and other substance use disorders: a new era on the horizon? doi.org/10.1172/JCI2... A Viewpoint by Lorenzo Leggio & W. Kyle Simmons

110

Journal of Clinical Investigation @jci.org · 13/09/2026

Sunday Spotlight💫: Proposing a combination treatment for reducing death from cerebral malaria: doi.org/10.1172/JCI2... Alvin H. Schmaier & team report on a role for bradykinin in cerebral malaria and find plasma kallkrein inhibitors target host-mediated vascular dysfunction.

000

Journal of Clinical Investigation @jci.org · 13/09/2026

Read the author’s response✏️: Jay D. Horton & colleagues reply to Making sense of cardiomyopathy caused by deletion of acetyl-CoA carboxylase 1 and 2: doi.org/10.1172/JCI2...

000

Journal of Clinical Investigation @jci.org · 13/09/2026

We previously posted about Kim et al. as a landmark in cardiac metabolism. In a recent Letter to the Editor✏️ Rong Tian & E. Douglas Lewandowski present Making sense of cardiomyopathy caused by deletion of acetyl-CoA carboxylase 1 and 2: doi.org/10.1172/JCI2... @the-asci.org

110

Journal of Clinical Investigation @jci.org · 12/09/2026

Revealing how chronic pain and emotional distress become linked: doi.org/10.1172/JCI2... Lu et al. find distinct brain circuits in the parafascicular nucleus independently drive facial pain and anxiety in trigeminal neuralgia.

120

Journal of Clinical Investigation @jci.org · 12/09/2026

Saturday Spotlight💫: As part of JCI’s review series on neurodegeneration, Erika Holzbaur & colleagues present: Mitophagy in neuronal health and disease: from mechanisms to neurodegeneration: doi.org/10.1172/JCI1...

000

Journal of Clinical Investigation @jci.org · 11/09/2026

The alpha and the omega (6 lipids): discovering dietary drivers of heterotopic ossification: doi.org/10.1172/JCI2... Peyton L. Carpen & Matthew B. Greenblatt provide a Commentary on Moye et al.: doi.org/10.1172/JCI2...

000

Journal of Clinical Investigation @jci.org · 11/09/2026

See the Commentary by Peyton L. Carpen & Matthew B. Greenblatt: doi.org/10.1172/JCI2...

000

Journal of Clinical Investigation @jci.org · 11/09/2026

Dietary omega-6 lipids promote post-injury aberrant bone formation in obesity: doi.org/10.1172/JCI2...

100

Journal of Clinical Investigation @jci.org · 11/09/2026

Dietary fats drive aberrant tissue repair in obesity: doi.org/10.1172/JCI2... Obesity is linked to impaired healing, including heterotopic ossification (HO) at the injury site. Benjamin Levi & team implicate dietary omega-6 lipids in this elevated risk for HO. @mathews-tom.bsky.social @the-asci.org

110

Journal of Clinical Investigation @jci.org · 10/09/2026

Menopause and “leaky gut”: implications for midlife women’s health: doi.org/10.1172/JCI2... Brandilyn A. Peters @dgsomucla.bsky.social comments on Shieh et al.: doi.org/10.1172/JCI2...

011

Journal of Clinical Investigation @jci.org · 10/09/2026

Take a look a the Commentary highlight by Brandilyn A. Peters: doi.org/10.1172/JCI2...

011

Journal of Clinical Investigation @jci.org · 10/09/2026

Gut barrier dysfunction during #menopause: doi.org/10.1172/JCI2... Shieh et al. report increases in markers of #GutBarrier permeability and microbial translocation-associated inflammation in 964 women before and after the menopausal transition.

222