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Bryan Roth

@zenbrainest.bsky.social
912 followers 79 following 587 posts

James Black: 'the prismatic qualities of the assay distort our view in obscure ways and degrees'

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Bryan Roth @zenbrainest.bsky.social · 11/09/2026
My analysis of $CMPS most recent data: --Strong 1 WK response --Relatively quick loss of efficacy --2nd dose helps --Modest differences at later stage --NO PLACEBO GROUP FOR THIRD PHASE
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Bryan Roth @zenbrainest.bsky.social · 14/08/2026
Chemogenetics human clinical trials.....
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Bryan Roth @zenbrainest.bsky.social · 14/08/2026
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Bryan Roth @zenbrainest.bsky.social · 18/06/2026
May his memory be a blessing Robert Thurman
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Bryan Roth @zenbrainest.bsky.social · 07/06/2026
Zen thought of the day:
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Bryan Roth @zenbrainest.bsky.social · 26/05/2026
I'm now recognized as 'an expert in chemogenetics'!
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Bryan Roth @zenbrainest.bsky.social · 21/05/2026
DREADDs in humans--update: 3 clinical trials using hM4Di in humans registered in China. 2 for epilepsy and 1 for Parkinson's Disease. In our original paper we stated: "...We suggest that at least one of these designer receptors, hM4D, will prove useful for neuronal silencing in vitro and in vivo.."
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Bryan Roth @zenbrainest.bsky.social · 17/05/2026
I'm giving a talk @ucsfmedicine.bsky.social Thursday All new, unpublished and, I think, tres cool. ccb.ucsf.edu/seminars-eve...
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Bryan Roth @zenbrainest.bsky.social · 10/05/2026
A great day at the Met!
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Bryan Roth @zenbrainest.bsky.social · 01/04/2026
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Bryan Roth @zenbrainest.bsky.social · 21/03/2026
That's a wrap!
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Bryan Roth @zenbrainest.bsky.social · 08/03/2026
Dose-response left-shifted...one now needs to be a very potent grant writer!
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Bryan Roth @zenbrainest.bsky.social · 02/02/2026
New lab logo from former postdoc Dewran
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Bryan Roth @zenbrainest.bsky.social · 14/12/2025
The YouTube lectures
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Bryan Roth @zenbrainest.bsky.social · 13/12/2025
Relates to this paper: www.biorxiv.org/content/10.6...
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Bryan Roth @zenbrainest.bsky.social · 13/12/2025
Intriguing--YES! Surprising--perhaps not so much One implication: do not take psychedelics if you have glioma..... www.biorxiv.org/content/10.6...
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Bryan Roth @zenbrainest.bsky.social · 23/11/2025
@superkash.bsky.social @markgbaxter.bsky.social I am King Riffraff
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Bryan Roth @zenbrainest.bsky.social · 22/11/2025
Not sooooo bad: prompt draw a diagram of how 5-HT2A receptor activation induces dendritic spine formation.....I agree with much of this, surprisingly
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Bryan Roth @zenbrainest.bsky.social · 15/11/2025
By far, the highlight of my visit to the Big Apple!
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Bryan Roth @zenbrainest.bsky.social · 01/11/2025
Before you throw tomatoes at me, please read the F***ing literature, dude open.substack.com/pub/zendudes...
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Bryan Roth @zenbrainest.bsky.social · 31/10/2025
My parting thought to all my scientific friends in Germany
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Bryan Roth @zenbrainest.bsky.social · 30/10/2025
Be there or be square
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Bryan Roth @zenbrainest.bsky.social · 22/10/2025
View of the day.
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Bryan Roth @zenbrainest.bsky.social · 07/10/2025
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Bryan Roth @zenbrainest.bsky.social · 06/10/2025
My unvarnished thoughts on todays Nobel Prize and prizes and 'high impact journals' open.substack.com/pub/zendudes...
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Bryan Roth @zenbrainest.bsky.social · 19/09/2025
So glad to hear I’m potentially qualified to be an Assistant Professor!
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Bryan Roth @zenbrainest.bsky.social · 10/08/2025
My unvarnished thoughts on psychedelics open.substack.com/pub/zendudes...
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Bryan Roth @zenbrainest.bsky.social · 10/08/2025
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Bryan Roth @zenbrainest.bsky.social · 06/08/2025
My recent email to @NIHDirector_Jay @RobertKennedyJr Please RT!
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Bryan Roth @zenbrainest.bsky.social · 20/07/2025
You are the
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Bryan Roth @zenbrainest.bsky.social · 16/07/2025
GRC Day 3 #psychedelics
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Bryan Roth @zenbrainest.bsky.social · 16/07/2025
GRC Day 3 #psychedelics
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Bryan Roth @zenbrainest.bsky.social · 14/07/2025
The psychedelic GRC so far:
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Bryan Roth @zenbrainest.bsky.social · 29/05/2025
Cool--thanks for sharing. Today I'll provide my opinion on how to use this information for targeted drug discovery. A glimmer is better than darkness!
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Bryan Roth @zenbrainest.bsky.social · 27/05/2025
Lisuride causes plasticity according to Olson patent: "FIG. 2E shows images of increased structural plasticity of neurons after treatment with Lisuride vs. the vehicle (DMSO)." US 2020/0030309 A1
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Bryan Roth @zenbrainest.bsky.social · 20/05/2025
View from garden today
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Bryan Roth @zenbrainest.bsky.social · 08/05/2025
Quite a nice image of 5-HT2A receptor distribution by Blake in the lab using our mice (I think now at JAX) pubmed.ncbi.nlm.nih.gov/37808655/
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Bryan Roth @zenbrainest.bsky.social · 06/05/2025
Many drugs used in treating Parkinson's Disease are quite similar potency agonists at 5-HT2A and D2/D3 but do not normally cause a psychedelic experience AND are not typically useful for depression, PTSD and so on. #psychedelics
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Bryan Roth @zenbrainest.bsky.social · 23/04/2025
In case anyone is in Montana tomorrow
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Bryan Roth @zenbrainest.bsky.social · 20/04/2025
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Bryan Roth @zenbrainest.bsky.social · 12/04/2025
A real email:
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Bryan Roth @zenbrainest.bsky.social · 01/04/2025
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Bryan Roth @zenbrainest.bsky.social · 19/03/2025
Dog park in Paris
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Bryan Roth @zenbrainest.bsky.social · 19/03/2025
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Bryan Roth @zenbrainest.bsky.social · 18/03/2025
Lunch in France
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Bryan Roth @zenbrainest.bsky.social · 16/03/2025
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Bryan Roth @zenbrainest.bsky.social · 16/03/2025
Lunch in Paris
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Bryan Roth @zenbrainest.bsky.social · 15/03/2025
Last of the Cuban
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Bryan Roth @zenbrainest.bsky.social · 12/03/2025
Breakfast in Paris
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Bryan Roth @zenbrainest.bsky.social · 25/02/2025
Dewran and Kunjie get the
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