The origin of paired fins is an unresolved controversy in vertebrate evolutionary biology. Karl Gegenbaur famously proposed that paired fins evolve...

Iain Cheeseman and colleagues reveal the underappreciated role of single genes producing multiple proteins in atypical presentations of rare disease, and present case studies of affected patients thro...

To study pathways that lead to aneuploidy during aging, the authors provide a system that enables cohesion protein depletion in mouse oocytes, mimicking effects that occur during aging. They uncover a...

Quiescence is a state in which cells undergo a prolonged proliferative arrest while maintaining their capacity to reenter the cell cycle. Here, we analyze entry and exit from quiescence, focusing on h...

The open ocean is a vast, highly connected environment, and the organisms found there have been hypothesized to represent massive, well-mixed populati…

Summary: VitelloTag, a method for transporting protein cargo into oocytes, facilitates microinjection-free CRISPR/Cas9 genome editing in multiple species.

Female reproductive aging is accompanied by a dramatic rise in the incidence of egg aneuploidy. Premature loss of chromosome cohesion proteins and untimely separation of chromosomes is thought to unde...

Mitochondrial endosymbiosis was a pivotal event in eukaryotic evolution, requiring core proteins to adapt to function both within the mitochondria and in the host cell. Here, we systematically profile...