An arrayed microscopy-based CRISPR screen revealed host genes affecting multiple infection phenotypes of the intracellular parasite Cryptosporidium. Hits in the host cholesterol biosynthesis pathway a...

If you’ve handled cat litter or eaten raw meat or unwashed produce, there’s a chance you might have a permanent toxoplasmosis infection spread throughout your body.

Discovery that the world’s most successful parasite can ‘decapitate’ sperm offers a new path to understanding rising infertility among men

Discovery that the world’s most successful parasite can ‘decapitate’ sperm offers a new path to understanding rising infertility among men

Discovery that the world’s most successful parasite can ‘decapitate’ sperm offers a new path to understanding rising infertility among men

imageimageDespite their clinical relevance, bradyzoite-filled cysts - the hallmark of chronic toxoplasmosis - are largely overlooked in current diagnostics. This study highlights bradyzoite serologica...

Toxoplasma gondii tachyzoites injected intraperitoneally crossed the blood-testes barrier, appearing in testes/epididymis by day 6 post-infection. In vitro exposure caused increased sperm necrosis/ap...

CRISPR screens reveal Toxoplasma’s GRA12 as a strain- and mouse species-transcendent virulence factor. GRA12 protects parasites from IFNγ-activated macrophage clearance and parasitophorous vacuole col...

Nature Communications - Ruivo et al uncover a Toxoplasma survival mechanism conserved across different cell types and species. By repressing NF-kB activation and lytic host cell death pathways, the...

Communications Biology - Early T. gondii infection induces host S-phase arrest and DNA breaks, with binucleation and micronuclei formation observed by 3 h p.i., indicating genomic...

This search is open to investigators conducting mechanistic studies of developmental cell biology using genetically tractable model organisms.

Toxoplasma gondii is a globally occurring apicomplexan parasite that infects humans and animals. Globally, different typical and atypical haplotypes of T. gondii induce varying pathologies in hosts. A...